Maintenance of Ideal Cardiovascular Health across the Life Course in Women

维持女性整个生命过程中理想的心血管健康

基本信息

批准号：
8821698
负责人：
Holly Catherine Gooding
金额：
$ 13.71万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8821698
关键词：
21 year old Address Adolescence Adolescent Adolescent and Young Adult Adult Age American Area Atherosclerosis Awareness Behavior Behavior Therapy Behavioral Biological Preservation Blood Pressure Boston Cardiovascular Diseases Cardiovascular system Cause of Death Child Childhood Cholesterol Chronic Disease Clinical Cognitive Cohort Analysis Cohort Studies Communication Research Coronary artery Coupled Data Data Analyses Deterioration Development Diabetes Mellitus Education Environment Epidemiologic Studies Epidemiology Ethnic group Female Female Adolescents Focus Groups Future Glucose Goals Growth Guidelines Health Health Care Costs Health Communication Health Promotion Individual Intervention K-Series Research Career Programs Lead Life Life Cycle Stages Life Expectancy Longevity Longitudinal Studies Maintenance Measures Mentors Mentorship Methodology Methods Modeling Morbidity - disease rate National Heart, Lung, and Blood Institute Patients Pattern Pediatric Hospitals Physiological Predisposition Probability Psychological Factors Public Health Practice Public Health Schools Qualitative Methods Qualitative Research Race Relative (related person)Research Research Personnel Research Training Risk Schools Staging Statistical Methods Techniques Testing Training Training Activity Translating United States Vulnerable Populations Woman Writing Youth biopsychosocial cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health career career development catalyst cohort design early adolescence early childhood effective intervention experience girls innovation meetings middle age mortality non-invasive imaging novel novel strategies patient oriented patient oriented research predictive modeling primary outcome public health relevance racial and ethnic secondary outcome young adult young woman

项目摘要

DESCRIPTION (provided by applicant): This patient-oriented K23 Career Development Award will provide the candidate with the training and research experience essential to launch an independent research career focused on the early prevention of cardiovascular disease in girls and women. Recent research has identified substantially lower cardiovascular morbidity and mortality in those women able to reach middle age with a constellation of physiologic and behavioral factors known as ideal cardiovascular health. However, little is known about earlier factors that are particularly salient for the maintenance of ideal cardiovascular health into adulthood in general or in women specifically. By using a novel technique of creating sequential risk prediction models in two epidemiologic cohorts with overlapping age ranges, the candidate will quantify the relative importance of cardiovascular health-promoting behavioral, physiologic, and psychological factors during the critical life stages of adolescence and early young adulthood. [The candidate will conduct qualitative studies to identify developmentally appropriate strategies for promotion of behaviors identified in the two cohort studies. The candidate will then be poised to write an R01 application focused on developing and evaluating targeted behavioral interventions for promoting ideal health among adolescent and young adult women from a variety of racial/ethnic backgrounds.] The training plan will support all aspects of the research strategy and uniquely prepare the candidate for an independent research career using longitudinal cohort analyses and qualitative research strategies to inform cutting edge patient-oriented behavioral interventions. The coursework, mentorship team, and research experiences are designed to provide synergistic training in 1) life course and chronic disease epidemiology, 2) statistical methods for studying critical windows in the life course, and 3) [patient-oriented health communications research that informs the design of developmentally appropriate behavioral interventions]. The Harvard School of Public Health, Harvard Graduate School of Education, Harvard Catalyst, and Boston Children's Hospital all offer unparalleled environments in these three areas. The candidate has assembled a mentorship team with expertise in cardiovascular epidemiology, child and adolescent health, longitudinal cohort analysis, focus group methodology, qualitative data analysis, and health communication and health promotion with vulnerable populations. Mentored by this team the candidate will be well-suited to achieve her immediate career goals of furthering her training in patient-oriented research and cardiovascular epidemiology, identifying critical windows in the lives of young women for cardiovascular health maintenance, and translating these findings to cardiovascular health promoting strategies in youth. [Training activities and results will inform submission of R01 proposals to conduct trials of behavioral interventions aimed at the unique needs of adolescent girls and young women and to conduct epidemiologic studies of cardiovascular health promoting factors in early childhood and the peri-natal period.] Ultimately the candidate's goals are to deepen the understanding of factors related to the maintenance of cardiovascular health throughout the life course and to design novel and effective interventions that enhance positive factors and counterbalance negative factors related to cardiovascular disease risk.

描述（由申请人提供）：这个面向患者的K23职业发展奖将为候选人提供最近的培训和研究。健康。和成年。最先进的面向患者的行为干预措施。适当的行为似乎是公共卫生，哈佛大学催化剂和波士顿儿童医院都提供了三个领域的未平行的环境。以及弱势群体的健康沟通和健康促进。 IES和结果将为R01提出的提议提供对青少年女孩的行为的试验，并在幼儿期和童年时期进行心血管健康和因素进行IC研究。 Healthout生活过程并设计新颖和最终查看干预措施，以增强与心血管疾病风险有关的现场因素和反球负面因素。