Redox Biology Center

氧化还原生物中心

基本信息

批准号：
9139478
负责人：
Donald F Becker
金额：
$ 84.08万
依托单位：
UNIVERSITY OF NEBRASKA LINCOLN
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9139478
关键词：
Address Automobile Driving Biology Biomedical Research Cataract Centers of Research Excellence Charge Collaborations Communities Complex Core Facility Disease Education and Outreach Educational Activities Extramural Activities Faculty Funding Goals Health Human Individual Institution International Lead Leadership Link Malignant Neoplasms Medical center Mentors Nebraska Nerve Degeneration Neurodegenerative Disorders Oxidation-Reduction Phase Pilot Projects Positioning Attribute Program Development Proteomics Research Research Infrastructure Research Personnel Research Project Grants Research Training Resources Services Spectrum Analysis Staging Training Training and Education Universities Vision Work bioimaging cardiovascular health career experience fighting improved innovation insight interdisciplinary collaboration member metabolomics novel novel therapeutic intervention outreach program programs research facility success

项目摘要

Founded in 2002 as an interdisciplinary partnership between researchers at the University of Nebraska-Lincoln (UNL) and the University of Nebraska Medical Center (UNMC), the Redox Biology Center (RBC) has grown into a nationally visible and internationally recognized program of excellence addressing fundamental questions crucial to fighting disease and improving human health. During Phases I and II, the RBC achieved its primary objective of enhancing Nebraska's biomedical research capacity through the creation of 1) a strategically linked infrastructure of strong research programs, 2) a program for mentoring talented junior faculty to independent success, 3) support for core research facilities in metabolomics/proteomics and spectroscopy/bioimaging, and 4) innovative educational activities. As a result, the RBC has developed a cadre of well-funded and productive faculty members conducting research leading to new insights in redox biology that have important implications in neurodegenerative diseases, cardiovascular health, cataracts, and cancer. Reaching the end of Phase II funding positions the RBC to move decisively toward its long-term vision of becoming a self-sustaining center of research excellence charged with providing international leadership and outstanding research resources benefiting other IDeA programs and the scientific community at large. Phase III funding will allow the RBC to attain this overarching goal by providing funds necessary to support meritorious multi-institutional research pilot projects that build the interdisciplinary collaborations necessary to maintain a strong center and compete for program project type funding while maintaining and expanding the RBC's research core facilities and promoting education and outreach. These three components - research pilot project program, core facilities (including a strong administrative core), and strong education/outreach programs, will allow the RBC to accomplish the specific aims set forth in this Phase III application: 1) Increase research capabilities, innovation, and extramural funding; 2) Strengthen research training and education in redox biology; and 3) Graduate from IDeA program funding as a self-sustainable center of research excellence in redox biology.

氧化还原生物学中心（RBC）成立于2002年，是作为内布拉斯加州林肯大学（UNL）和内布拉斯加州医学中心（UNMC）的研究人员之间的跨学科伙伴关系，已成长为一项全国可见和国际知名的卓越计划，以解决对疾病至关重要的疾病和改善人类健康的基本问题。在第I和II阶段，RBC实现了通过创建内布拉斯加州的生物医学研究能力的主要目标。1）强大的研究计划的战略性联系的基础架构，2）一项计划，用于指导才华横溢的初级教职员工为独立的成功，3）3）对新生组学/蛋白质学的核心研究设施的支持，并进行了蛋白质组学/蛋白质学教育和光谱学/Bioimimimimimimics和4）和4）。结果，加拿大皇家银行（RBC）开发了一批资金丰富且富有成效的教职员工，他们进行了研究，从而导致了氧化还原生物学的新见解，这些见解对神经退行性疾病，心血管健康，白内障和癌症具有重要意义。达到第二阶段资金的结束，加拿大皇家银行（RBC）果断地朝着其长期的愿景迈向成为自我维持的研究卓越中心，该中心负责提供国际领导和杰出的研究资源，从而使其他思想计划和整个科学界受益匪浅。第三阶段的资金将使加拿大皇家银行通过提供必要的资金来支持有功的多机构研究试点项目，从而建立必要的资金，以建立维持强大的中心并争夺计划项目类型资金所需的跨学科合作，同时维持和扩展RBC的研究核心设施和扩展。这三个组成部分 - 研究试点项目计划，核心设施（包括强大的行政核心）以及强大的教育/外展计划，将使加拿大皇家银行能够实现本III阶段应用中规定的具体目标：1）提高研究能力，创新和外部资金； 2）加强氧化还原生物学的研究培训和教育； 3）从Idea计划资助毕业，是氧化还原生物学卓越研究中心的自我维持中心。