Molecular Mechanisms of Disease

疾病的分子机制

• 批准号: 10410436
• 负责人: Donald F Becker
• 金额: $ 25.13万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410436
• 关键词: Disease; Molecular

This proposal seeks funding for the Molecular Mechanisms of Disease (MMoD) predoctoral training program at the University of Nebraska-Lincoln. The MMoD program addresses the NIH training focus of Cellular, Biochemical, and Molecular Sciences by providing advanced training and career development in biomedical research centered on molecular interactions and chemical transformations. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The MMoD program will (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for six predoctoral trainees per year (NIH-supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that enables trainees to develop professional skills in communication, leadership, proposal-writing, scholarship, entrepreneurship, and teaching; and 3) Build a cohort of trainees from diverse perspectives that have the knowledge and ability to work at the crossroads of different disciplines in their future careers as PhD scientists. The MMoD program provides collaborative training in mechanistic disease research in the areas of molecular signaling, metabolic integrity, oxidative stress and redox biology, and disease microenvironment. The MMoD mentoring team spans seven departments and three colleges and includes 32 faculty members from early-stage to established investigators with strong histories in biomedical research funding and graduate student mentoring. Trainees will conduct four research rotations in year 1 before choosing a faculty mentor, and will be supported by NIH T32 funding for up to two years beginning in the second year of their five-year program. Selection of new trainees for NIH support will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. Trainees will take a flexible core curriculum that includes a course on Metabolic Function and Dysfunction, and a quantitative biology course and two macromolecules courses from an approved core. Though these courses and MMoD training modules, students will acquire skills in evidence-based education, quantitative and critical analysis, and, rigor and reproducibility in research. They will also have opportunities for professional experiences related to intellectual property and the pharmaceutical industry in preparation for potential career options. The MMoD program provides a framework that enables trainees to gain a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers.

该提案寻求用于疾病分子机制（MMOD）培训前培训计划的资金 内布拉斯加州林肯大学。 MMOD程序介绍了Cellular的NIH训练重点， 通过提供生物医学的先进培训和职业发展，生化和分子科学 研究以分子相互作用和化学转化为中心。该程序的目的是 培养在合作多学科团队研究疾病的杰出新科学家 使用定量方法的机制最终产生了预防和治疗的切实策略。 为了实现这一目标，该计划将招募高质量的，有动力的学者 对人类疾病的根本原因的兴趣，并参与受过指导的尖端研究。这 MMOD计划（1）将为严格的课程和创新的协作研究机会提供 每年六名五名学生（由NIH支持）成为人类机械研究的专家 疾病; （2）培养互动培训环境，使学员能够发展专业技能 沟通，领导，提案写作，奖学金，企业家精神和教学； 3）建造一个 从不同的角度来看，学员的同伙具有知识和能力 在未来的职业生涯中，不同学科是博士学位科学家。 MMOD计划提供协作 分子信号传导，代谢完整性，氧化领域的机械疾病研究培训 压力和氧化还原生物学以及疾病微环境。 MMOD指导团队跨越了七个 部门和三所大学，包括32名教职员工，从早期到成熟的调查员 在生物医学研究资金和研究生指导方面拥有悠久的历史。学员将进行四个 在选择教师导师之前，第一年的研究轮换，并将获得NIH T32资金的支持 到他们五年计划的第二年开始两年。选择新学员的NIH支持 基于强大的学术记录，研究进度和潜力，将具有竞争力，并且是原始的 协作提案桥接创新论文研究的学科界限。学员将接受 灵活的核心课程，包括有关代谢功能和功能障碍的课程，并定量 来自认可的核心的生物学课程和两个大分子课程。虽然这些课程和MMOD 培训模块，学生将获得基于证据的教育，定量和批判性分析的技能， 而且，研究中的严格性和可重复性。他们还将有机会与专业经验有关 为知识产权和制药行业做准备，以准备潜在的职业选择。 mmod 计划提供了一个框架，使学员能够获得广泛的知识基础；积极寻求研究 合作；产生原始发表研究的杰出记录；并开发演示文稿， 提案编写和领导技能将使他们成为独立研究人员的未来卓越。