Molecular Mechanisms of Disease

疾病的分子机制

• 批准号: 9068968
• 负责人: Donald F Becker
• 金额: $ 23.99万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9068968
• 关键词: Disease; Molecular

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln proposes to establish the Molecular Mechanisms of Disease (MMoD) predoctoral training program to provide innovative training and career development in biomedical research centered on molecular interactions and chemical transformations. The program bridges a nine-state gap in the NIH training focus of Cellular, Biochemical, and Molecular Sciences. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The specific aims are to: (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for sixteen predoctoral trainees per year (eight NIH-supported and eight institutionally supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that emphasizes development of outstanding skills in professional networking, grantsmanship, leadership, and written and oral communication; (3) Support collaborative training efforts of mentors in four areas of mechanistic disease research emphasis: molecular signaling, metabolic integrity, oxidative stress, and disease microenvironment. NIH support will span two years of a five-year program for trainees with undergraduate laboratory experience and one year of graduate-level coursework prior to the T32 training period. Selection of new trainees will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. The MMoD mentoring team spans seven departments and three colleges and includes 28 faculty members, all with strong histories in biomedical research funding and graduate student mentoring. Trainees will complete four research rotations in year 1 before choosing a faculty mentor representing one of the four emphasis areas. Trainees will take a flexible core curriculum: Metabolic Function and Dysfunction, one Quantitative Biology course from an approved core, and two Macromolecules courses from an approved core. Through these courses, they will receive formal training in grantsmanship, scientific writing, and research and journal article presentations. They will also be provided with unique entrepreneurial learning and teaching opportunities and will organize an annual symposium centered on the meeting of the program's external advisory committee. The MMoD program will provide a framework that enables trainees to assemble a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers focused on mechanisms of disease progression.

 描述（由申请人提供）：内布拉斯加大学林肯分校提议建立疾病分子机制（MMoD）博士前培训计划，以提供以分子相互作用和化学转化为中心的生物医学研究的创新培训和职业发展。该计划连接了九个领域。 -国家卫生研究院细胞、生物化学和分子科学培训重点的差距 该项目的目标是培养在多学科协作团队中工作的杰出新科学家，利用定量研究疾病机制。为了实现这一目标，该项目将招募对人类疾病的根本原因有浓厚兴趣的高素质、积极主动的博士前实习生，并让他们参与指导性的、前沿的具体研究。目标是：(1) 每年为 16 名博士前培训生（8 名由 NIH 支持，8 名由机构支持）提供严格的课程和创新的合作研究机会，使他们成为人类疾病机制研究的专家；(2) 培养互动性；训练环境强调发展专业网络、资助、领导力以及书面和口头交流方面的杰出技能；（3）支持导师在机械疾病研究重点的四个领域的协作培训工作：分子信号传导、代谢完整性、氧化应激和疾病微环境。 NIH 的支持将涵盖为具有本科实验室经验的学员提供两年的五年计划以及 T32 培训期之前一年的研究生水平课程，新学员的选拔将基于良好的学术记录、研究进展和能力。 MMoD 指导团队涵盖七个系和三个学院，包括 28 名教职人员，他们在生物医学研究资助和研究生指导方面都有丰富的经验。在选择代表四个重点领域之一的教师导师之前，学员将在第一年学习灵活的核心课程：代谢功能和功能障碍，一门来自批准核心的定量生物学课程，以及两门来自批准核心的大分子课程。通过这些课程，他们将接受资助、科学写作和研究方面的正式培训。 他们还将获得独特的创业学习和教学机会，并将组织一次以该计划外部咨询委员会会议为中心的年度研讨会。MMoD 计划将提供一个框架，使学员能够建立广泛的知识库。积极寻求研究合作；创造出色的原创发表研究记录；并培养演讲、提案撰写和领导技能，使他们能够成为专注于疾病进展机制的独立研究人员。