Administrative Core

行政核心

基本信息

批准号：
10264661
负责人：
Charles DeCarli
金额：
$ 53.25万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10264661
关键词：
Address Adherence Advisory Committees Affect Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Animal Welfare Annual Reports Award Behavioral Research Biological Markers Caregiver research Caring Clinical Cognitive Cognitive aging Collaborations Communities Data Data Set Dementia Development Diagnosis Disease Early Diagnosis Ensure Environment Epidemiology Faculty Funding Funding Agency Future Geography Goals Grant Growth Heterogeneity Image Infrastructure International Leadership Longevity Minority Groups Mission Outcome Participant Pathology Policies Population Heterogeneity Process Research Research Personnel Research Project Grants Research Training Resources Risk Risk Factors Sampling Science Scientist Serum Strategic Planning Time Training Training Programs United States National Institutes of Health Vision Work aging brain caregiving collaborative environment community based research complement resource data exchange ethnic minority population flexibility high risk human subject improved innovation next generation novel outreach prevent programs racial minority recruit study population success therapy development treatment strategy undergraduate student

项目摘要

PROJECT SUMMARY/ABSTRACT - Administrative Core The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging while caring for those affected by dementia. To accomplish this mission, we have created a highly integrated and collaborative environment with extensive resources to support studies on the heterogeneity of cognitive aging and progression to dementia among diverse populations. The Administrative Core (AC) supports this mission through overall direction and optimal utilization of center resources with emphasis on strategies that encompass 1) development of new research initiatives, 2) leveraging available resources through integration of research effort and pursuit of research funding, 3) program growth through local, national and international collaborations and initiation of new programs, and, finally, 4) pursuit of funding sources for training of junior scientists so as to expand and provide continuity for our program of research on aging and ADRD. Our approach addresses a number of milestones set by the National Alzheimer’s Project Act by 1) evaluating disparities among ethnic and racial minority populations that are at higher risk for AD to mitigate risk and improve cognitive outcomes, 2) fully characterizing mixed pathologies and identifying unique risk factors,3) accelerating the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease (AD), 4) improving early diagnosis through discovery of novel imaging and serum biomarkers, 5) developing novel dementia treatment strategies, and 6) supporting caregiving through funded caregiver research. The AC also has a long tradition of supporting the overall NIA ADC Network to achieve NAPA goals “…through increasing flexibility and collaboration by leveraging resources, capabilities and research participants across the network”. Consistent with our overall approach, the AC also has historically contributed to efforts to “…unify goals, ensure that resources are most efficiently utilized, and is suitably flexible to facilitate the ability of the ADC network to respond to a dynamic scientific environment while incorporating the needs of all stakeholders…” As such, the AC provides outstanding leadership along with the infrastructure and the administrative support needed to meld the various Cores and geographically dispersed units of the UCD ADRC into a true, coherent and effective research center. Specifically, the AC will direct and strategically plan to utilize the full complement of resources and expertise of the UCD ADRC, incorporating the developmental projects, our community based research approach and extensive research training program to fulfill the milestones of NAPA.

项目摘要/摘要 - 行政核心加州大学戴维斯分校阿尔茨海默病研究中心 (UCD ADRC) 的使命是推进阿尔茨海默氏症研究的科学发展健康的大脑老化，同时照顾痴呆症患者为了完成这一使命，我们有。创建了一个高度集成和协作的环境，拥有广泛的资源来支持研究关于不同人群认知衰老和痴呆进展的异质性。行政核心 (AC) 通过总体指导和中心的优化利用来支持这一使命资源重点关注战略，包括 1) 开发新的研究计划，2) 通过整合研究工作和寻求研究经费来利用可用资源，3) 通过地方、国家和国际合作以及新项目的启动来促进项目的发展，以及最后，4）寻求培训初级科学家的资金来源，以扩大和提供连续性我们的老龄化和 ADRD 研究计划实现了许多里程碑。国家阿尔茨海默病项目法案通过 1) 评估少数族裔和种族人口之间的差异，患有 AD 的风险较高，可以降低风险并改善认知结果，2) 充分表征混合病理学并确定独特的风险因素，3）加速开发治疗方法预防、阻止或逆转阿尔茨海默病 (AD) 的病程，4) 通过以下方式改善早期诊断发现新的成像和血清生物标志物，5) 开发新的痴呆症治疗策略，以及 6) 通过资助研究来支持护理工作 AC 也有着支持护理的悠久传统。整体 NIA ADC 网络实现 NAPA 目标“……通过提高灵活性和协作 “利用整个网络的资源、能力和研究参与者”。方法，审计委员会历来也致力于“……统一目标，确保资源最有效” 有效利用，并且具有适当的灵活性，以促进 ADC 网络响应动态的能力科学环境，同时纳入所有利益相关者的需求……”因此，AC 提供出色的领导力以及融合各种所需的基础设施和行政支持都柏林大学 ADRC 的核心和地理上分散的单位进行真实、连贯和有效的研究具体而言，审计委员会将直接进行战略规划，利用全部资源和资源。都柏林大学 ADRC 的专业知识，结合了发展项目、我们基于社区的研究方法和广泛的研究培训计划，以实现国家适应行动方案的里程碑。