Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

拉丁裔研究-神经认知衰老-阿尔茨海默病的调查

• 批准号: 10629449
• 负责人: Charles DeCarli
• 金额: $ 576.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629449
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Biological; Biological Aging; Biological Markers; Biology; Blood Vessels; Brain; California; Cardiovascular Diseases; Cardiovascular system; Censuses; Cerebrovascular Trauma; Chronic; Cognitive; Cognitive aging; Country; Data; Dementia; Diabetes Mellitus; Disparate; Disparity; Elderly; Epigenetic Process; Ethnic Origin; Exposure to; Face; Funding; Genes; Genetic; Genetic Risk; Genomics; Genotype; Goals; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Impaired cognition; Investigation; Knowledge; Latino; Latino Population; Magnetic Resonance Imaging; Measures; Mendelian randomization; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurocognitive; Pathology; Plasma; Population; Population Growth; Population Heterogeneity; Public Health; Research; Risk; Risk Factors; Structure; Study of Latinos; Subgroup; Texas; Therapeutic Intervention; Training; Vascular Diseases; Vascularization; Visit; aging brain; bilingualism; brain tissue; burden of illness; cardiovascular disorder risk; career; cohort; critical period; dementia risk; disease phenotype; ethnic difference; experience; health disparity; improved; middle age; neuroimaging marker; polygenic risk score; prevent; preventive intervention; racial population; social culture; sociocultural determinant; symposium; tau-1; vascular contributions

Abstract By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD) morbidity contributing to disparately high ADRD. CVD risk factors emerge early in midlife among Latinos, thereby increasing exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-date there has not been any study of Latinos with sufficiently deep CVD phenotyping and genotyping to adequately address this significant public health question. This scientific knowledge gap is a significant impediment to the field and public health given rapid Latino population growth projections, particularly for older adults. The Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer’s Disease (SOL-INCA-AD) will augment the ongoing large, representative and unique cohort with 10-years of advanced biomarkers of Alzheimer's disease to understand cognitive aging and impairment amongst diverse Latinos. Together with 10-years of cognitive measures, MRI, deep CVD phenotyping, genomics and rich sociocultural data, SOL-INCA-AD is a high priority study that will fill major scientific knowledge gaps that form barriers to progress for Latino ADRD research.

抽象的 CDC 预测，到 2060 年，拉丁裔人口的阿尔茨海默氏症发病率将出现最大增幅 美国所有族裔/种族群体的疾病及相关痴呆（ADRD）病例高的主要原因。 拉丁裔 ADRD 很大程度上归因于早期和过度的心血管疾病 (CVD) 发病率 拉丁裔中年早期出现不同程度的高 ADRD 危险因素，从而增加 然而，迄今为止还没有任何暴露于极其敏感和高度血管化的脑组织的情况。 对拉丁美洲人进行足够深入的 CVD 表型和基因分型研究，以充分解决这一问题 这种科学知识差距是该领域的重大障碍。 鉴于拉丁裔人口快速增长的预测，尤其是老年人的研究。 拉丁裔 - 神经认知老化 - 阿尔茨海默氏病的调查 (SOL-INCA-AD) 将增强 正在进行的大型、具有代表性和独特的队列，具有 10 年先进的阿尔茨海默病生物标志物 疾病来了解不同拉丁美洲人的认知衰老和障碍以及 10 年的认知障碍。 SOL-INCA-AD 包含认知测量、MRI、深度 CVD 表型、基因组学和丰富的社会文化数据 高优先级研究将填补阻碍拉丁裔进步的主要科学知识差距 ADRD 研究。