LOCAL FIELD POTENTIALS IN THE BASAL GANGLIA

基底神经节的局部场潜力

• 批准号: 8172383
• 负责人: Thomas N Wichmann
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172383
• 关键词: Acute; Algorithms; Animals; Back; Basal Ganglia; Cell Nucleus; Chronic; Combined Modality Therapy; Computer Retrieval of Information on Scientific Projects Database; Deep Brain Stimulation; Devices; Dopamine; Dopamine Antagonists; Dopamine Receptor; Dopaminergic Agents; Funding; Grant; Injection of therapeutic agent; Institution; Measures; Microdialysis; Modeling; Monitor; Monkeys; Neurons; Neurotoxins; Neurotransmitters; Parkinsonian Disorders; Patients; Pharmaceutical Preparations; Primates; Property; Research; Research Personnel; Resources; Role; Series; Signal Transduction; Source; Structure; Thalamic structure; United States National Institutes of Health; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cortical inputs reach basal ganglia structures, which project back to thalamus and cortex. Due to the lack of the neurotransmitter dopamine, synchronized oscillatory and non-oscillatory activity appears in the basal ganglia which can be measured with local field potential (LFP) recordings. In our primate experiments, we study recordings of LFP changes that are associated with the induction of parkinsonism by treatment with the neurotoxin MPTP. We also study the local effects of dopaminergic drugs on neuronal synchrony in the basal ganglia nuclei, using a microdialysis/LFP recording probe which allows us to assess the effects of drugs, applied locally via reverse microdialysis, on LFPs in the vicinity of the probe. We have continued our experiments of LFP changes in parkinsonian animals. The studies are carried out in monkeys that are undergoing a slow course of MPTP treatment, combined with monitoring of parkinsonian signs. While we are currently recording in the third animal in this series, a fourth animal is being prepared for the studies. The results of these experiments (as well as those of systemic dopamine receptor antagonist injections) demonstrate that acute dopamine receptor blockade is not sufficient to produce significant LFP changes in the basal ganglia, while chronic dopamine depletion produces changes in oscillatory LFP properties. These findings, together with the emerging evidence of anatomical differences between acute and chronic dopamine depletion models, suggest that dopamine loss alone is not sufficient to alter oscillations, and that secondary anatomical changes may have to occur to produce changes in the oscillatory properties. These findings further clarify the role of dopaminergic and non-dopaminergic changes in the basal ganglia in parkinsonism. A thorough understanding of the relationship between LFP changes and parkinsonism may help us to develop predictive algorithms that can be used as control signals in on-demand deep brain stimulation devices for parkinsonian patients.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 皮质输入到达基底神经节结构，这些结构向丘脑和皮层投射。由于缺乏神经递质多巴胺，基础神经节中出现同步振荡和非振荡活性，可以用局部田间电位（LFP）记录进行测量。在我们的灵长类动物实验中，我们研究了通过用神经毒素MPTP治疗的LFP变化的记录，这些变化与帕金森氏症有关。 我们还使用微透析/LFP记录探针研究了多巴胺能药物对基底神经节核中神经元同步的局部作用，该探针使我们能够评估药物的效果，该药物通过反向微透析局的局部应用，对探针的LFP对LFP进行验证。 我们继续对帕金森动物的LFP变化进行实验。 这些研究是在正在进行MPTP治疗缓慢的猴子中进行的，结合了对帕金森氏症标志的监测。 当我们目前正在本系列中记录第三只动物时，正在为研究准备第四只动物。 这些实验（以及全身多巴胺受体拮抗剂注射的结果）的结果表明，急性多巴胺受体阻滞不足以在基底神经节中产生显着的LFP变化，而慢性多巴胺耗竭会产生振荡性LFP特性的变化。 这些发现以及急性和慢性多巴胺消耗模型之间解剖学差异的新兴证据表明，单独的多巴胺损失不足以改变振荡，并且可能必须发生次要解剖学变化来产生振荡性质的变化。 这些发现进一步阐明了帕金森氏症基底神经节中多巴胺能和非多巴胺能变化的作用。 对LFP变化和帕金森氏症之间的关系有透彻的了解可能有助于我们开发预测算法，这些算法可以用作帕金森病患者的按需深脑刺激装置中的对照信号。