Udall Parkinson's Disease Research Center at Emory University

埃默里大学尤德尔帕金森病研究中心

• 批准号: 9975930
• 负责人: Thomas N Wichmann
• 金额: $ 128.73万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975930
• 关键词: Address; Administrator; Affect; Algorithmic Analysis; American; Anatomy; Animals; Antiparkinson Agents; Area; Assisted Living Facilities; Basal Ganglia; Basic Science; Behavior; Behavior Control; Brain; Caregivers; Cell Nucleus; Cells; Cerebral cortex; Child; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Community Outreach; Complement; Data Analyses; Deep Brain Stimulation; Development; Disease; Education; Education and Outreach; Educational Activities; Electron Microscopy; Fostering; Foundations; Functional disorder; Funding; Future Teacher; General Population; Goals; Grant; High School Student; Human Resources; Immunohistochemistry; Information Centers; Institutes; Institution; Journals; K-12 student; Knowledge; Light; Link; Mission; Modeling; Monkeys; Morphology; Motivation; Movement Disorders; Neurosciences; Parkinson Disease; Parkinsonian Disorders; Patients; Pattern; Physiology; Population; Primates; Recommendation; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Role; Scientist; Series; Services; Slice; Social Workers; Societies; Standardization; Structure; Students; Synapses; Thalamic structure; Therapeutic Intervention; Time; Tissue Sample; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Work; age group; biomedical referral center; career; career development; clinical care; clinical movement disorder; clinical translation; collaborative environment; data sharing; design; experience; experimental study; in vivo; innovation; insight; interest; intervention effect; laboratory experience; motor control; neuroregulation; outreach; outreach program; programs; relating to nervous system; retiree; science education; side effect; symposium; virtual; web site

The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson's Disease Research at Emory University is a collaborative research program in which electrophysiologists and anatomists study the pathophysiology of parkinsonism, and examine and optimize the effects of existing treatments for Parkinson's disease. The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct translational research. Other Udall Center assets are its close ties to the clinical movement disorders group at Emory, and the availability of primates for research at the Yerkes National Primate Research Center at Emory University. Emory is strongly committed to the Udall Center's research, and supports the Center by funding pilot grants, invited speakers, and portions of its education and outreach programs. The Center consists of three tightly linked projects and two cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes in thalamus and cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize existing neuromodulation strategies and to develop new ones. Project 1 (led by Dr. Jaeger) will utilize brain slice and in vivo recordings in rodents, as well as a neural computational approach to develop mechanistic models of thalamocortical dysfunction in parkinsonism. Project 2 (Dr. Wichmann), will continue the exploration of thalamic and cortical abnormalities in parkinsonian monkeys, using selective activation and inactivation approaches which are designed to study corticothalamic, pallidothalamic and thalamocortical information transfer. Project 3 (Dr. Smith) will examine morphological changes in the thalamic and cortical microcircuitry in parkinsonian primates, a topic that is virtually unexplored at this time and of high relevance to the interpretation of data in the other projects. All projects will be supported by an Administrative Core (Dr. Wichmann, PI; Dr. DeLong, Co-I, Dr. Smith, Co-I, Ms Holbrook, administrator), and by an Anatomy and Behavior Core (Dr. Galvan) which will provide immunohistochemistry and electron microscopy services to all of the center projects, and standardized MPTP treatment and quantification of parkinsonism to the primate experiments in Projects 2 and 3. In addition to pursuing its research mission (Aim 1), the Center will help junior scientists to develop their career in Parkinson's disease research (Aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center's (and Udall Center network) research findings to the public (Aim 3), reaching all age groups and background levels, ranging from K-12 children to retirees in assisted living facilities. As part of the outreach agenda, the center plans to organize annual symposia for patients and their caregivers. The center will be generously supported by the University. These internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand Parkinson's disease research at Emory University.

埃默里大学（Emory University）的莫里斯·K·乌达尔·帕金森（Morris K.该中心借鉴了埃默里（Emory）基底神经节研究界进行转化研究的良好能力。其他UDALL中心资产是与埃默里（Emory）的临床运动障碍小组的密切联系，以及在埃默里大学（Emory University）的Yerkes国家灵长类动物研究中心提供的研究灵长类动物的可用性。埃默里（Emory）强烈致力于Udall中心的研究，并通过资助飞行员赠款，受邀演讲者以及部分教育和外展计划来支持该中心。 该中心由三个紧密联系的项目和两个核心组成。计划的研究将阐明丘脑和皮质中与帕金森氏症相关的活动变化，这反过来又将帮助我们更好地了解帕金森氏症的病理生理学，并优化现有的神经调节策略并制定新的神经调节策略。项目1（由Jaeger博士领导）将利用啮齿动物中的脑切片和体内记录，以及一种神经计算方法，用于开发帕金森氏症丘脑皮质功能障碍的机械模型。项目2（Wichmann博士）将继续使用选择性激活和灭活方法来探索帕金森尼猴子中丘脑和皮质异常的探索，这些方法旨在研究皮质丘脑，pallidototothalamic和thalamoforical Information Crossion转移。项目3（史密斯博士）将检查帕金森氏症灵长类动物的丘脑和皮质微环路的形态变化，这个话题实际上尚未探索，并且与其他项目中数据的解释具有很高的相关性。所有项目都将得到行政核心的支持（Wichmann博士，PI； Delong博士，Co-I博士，Smith博士，Co-I博士，Co-I，Mes Holbrook，Administrator），以及由解剖学和行为核心（Galvan博士）这将为所有中心项目提供免疫组织化学和电子显微镜服务，并在项目2和3中对灵长类动物实验进行标准化的MPTP治疗以及对帕金森氏症的定量。除了追求其研究任务外（AIM 1），该中心还将帮助初级工作。科学家在帕金森氏病研究（AIM 2）中发展职业，并将从事广泛的外展工作，旨在向公众传达该中心（和Udall Center网络）的研究结果（AIM 3），触及所有年龄段和背景级别从K-12儿童到辅助生活设施的退休人员不等。作为外展议程的一部分，该中心计划为患者及其护理人员组织年度研讨会。该中心将得到大学的慷慨支持。这些内部支持资金将有助于该中心资助其一些教育和外展任务，以及其试点赠款计划，旨在扩大埃默里大学的帕金森氏病研究。

项目成果

Meta-Bayesian Optimization for Deep Brain Stimulation.

深部脑刺激的元贝叶斯优化。

• DOI: 10.1109/embc48229.2022.9871279
• 发表时间: 2022
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Connolly,MarkJ;Opri,Enrico;Miocinovic,Svjetlana;Devergnas,AnnaelleD
• 通讯作者: Devergnas,AnnaelleD

Automated deep brain stimulation programming with safety constraints for tremor suppression in patients with Parkinson's disease and essential tremor.

• DOI: 10.1088/1741-2552/ac86a2
• 发表时间: 2022-08-18
• 期刊: JOURNAL OF NEURAL ENGINEERING
• 影响因子: 4
• 作者: Sarikhani, Parisa;Ferleger, Benjamin;Mitchell, Kyle;Ostrem, Jill;Herron, Jeffrey;Mahmoudi, Babak;Miocinovic, Svjetlana
• 通讯作者: Miocinovic, Svjetlana