Morris K. Udall Centers of Excellence for Parkinson's Disease Research at Emory University

埃默里大学莫里斯·尤德尔帕金森病研究卓越中心

• 批准号: 10284843
• 负责人: Thomas N Wichmann
• 金额: $ 239.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-29 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10284843
• 关键词: Address; Administrator; Affect; Algorithmic Analysis; American; Anatomy; Animals; Antiparkinson Agents; Area; Basal Ganglia; Basic Science; Behavior Control; Behavior assessment; Brain; Caregivers; Cell Nucleus; Cells; Cerebral cortex; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Community Outreach; Complement; Data Analyses; Deep Brain Stimulation; Development; Disease; Dopaminergic Agents; Education; Education and Outreach; Educational Activities; Electrocorticogram; Electroencephalography; Event; Fostering; Foundations; Functional disorder; Funding; General Population; Goals; Grant; Human; Human Resources; Image; Information Centers; Institution; Journals; K-12 student; Knowledge; Levodopa; Light; Logistics; Mission; Modeling; Monkeys; Morphology; Motor; Motor Cortex; Movement Disorders; Neurons; Neurosciences; Parkinson Disease; Parkinsonian Disorders; Patients; Pattern; Physiology; Population; Primates; Recommendation; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Rodent; Role; Scientist; Series; Services; Signal Transduction; Slice; Social Workers; Societies; Structure; Students; Synapses; Therapeutic; Therapeutic Intervention; Tissue Sample; Training; Translational Research; Universities; Work; age group; biomedical referral center; career; catalyst; clinical care; clinical translation; collaborative environment; connectome; data sharing; design; experience; experimental study; in vivo; innovation; insight; interest; intervention effect; laboratory experience; motor control; nonhuman primate; outreach; parkinsonian non-human primate; programs; recruit; relating to nervous system; response; science education; side effect; statistical service; symptom treatment; treatment optimization; virtual; voltage; web site

Project Summary – Overall Center The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson’s Disease Research at Emory University is a collaborative research program that studies the pathophysiology of parkinsonism with the goal of optimizing the treatment for Parkinson’s disease (PD). The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct collaborative translational research. Other Udall Center assets are the availability of primates for research at the Yerkes National Primate Research Center at Emory, and the presence of one of the largest movement disorders clinic in the US. The Center consists of four projects and three cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes of specifically identified groups of projection neurons in the cerebral cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize therapeutic strategies. Project 1 (led by Dr. Jaeger) will utilize rodent experiments for large-scale voltage imaging and brain slice recordings and use neural computational approaches to develop mechanistic models of cortical dysfunction in parkinsonism. Project 2 (Dr. Galvan), will explore the spontaneous and task-related activity of corticostriatal and corticospinal neurons in the primary motor cortex (M1) and the supplementary motor area (SMA) in normal and parkinsonian monkeys, using an opto-tagging approach to identify the projection targets of the recorded neurons. Project 3 (Dr. Smith) will examine morphological changes in the M1 and SMA microcircuitry and parkinsonism-associated changes in the connectome of cortical projection neurons in primates, a topic that is virtually unexplored and of high relevance to the interpretation of data in projects 1 and 2. The clinical ‘Catalyst’ project 4 is an examination of parkinsonism-related changes in cortical activity in response inhibition tasks, studied in electrocorticography and electroencephalography signals in patients with PD. The functional experiments will also study the effects of levodopa and deep brain stimulation treatments in these paradigms. All projects will be supported by an administrative core (Core A, Dr. Wichmann, PI; Dr. Smith, Associate Director, Ms Holbrook, administrator), and by a service core that provides anatomical services to projects 1 and 2, behavioral assessments to projects 2 and 3, and statistical services to all projects (Core B, Dr. Galvan). A clinical core (Core C) will support project 4 with recruitment and logistic services for the human studies. In addition to pursuing its research mission (aim 1), the Center will help young scientists to develop their career in PD research (aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center’s (and Udall Center network) research findings to the public (aim 3), reaching all age groups and background levels. As part of the outreach agenda, the center plans to organize annual outreach events for patients and their caregivers. Generous internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand PD research at Emory.

项目摘要 - 整体中心 莫里斯·帕金森氏病帕金森氏病帕金森氏病研究中心 大学是一项协作研究计划。 构成帕金森氏病的治疗（PD）。 Emory的神经节研究社区进行合作研究。 在美国最大的Mosorders诊所之一的存在。 帮助我们改善帕金森氏症的病理生理学，并优化治疗策略。皮质纹状体和 一级运动皮质（M1）中的皮质脊髓神经元和正常的供应运动区域（SMA） 帕金森·猴子（Parkinsonian Monkeys）在M1和Smicrocirocuitry和帕金森氏症相关的变化中使用逻辑上的变化来进行帕金森·猴子。项目1和2中的数据。在居住任务中对帕金森氏症与皮质活动相关的变化 PD患者的电视图和脑电图信号 还将研究这些范式中左旋多巴和深脑刺激的影响 将由行政核心（Core A，Wichmann博士，PI； Smith博士，MS）提供支持。 霍尔布鲁克（Holbrook），管理员），以及针对所有项目的项目1和2的服务核心服务（Core B，Galvan博士） Core（Core C）将支持项目4的招聘和物流服务。 该中心追求其研究任务（AIM 1），将有助于发展其在PD研究（AIM 2）Eutreach effors的职业，旨在传达该中心的职业（以及Udall 中心网络）对公众的研究结果（AIM 3），以所有年龄段和背景水平达到一部分。 在外展议程中，该中心计划组织年度外展活动，以供专门及其护理人员组织。 慷慨的内部支持资金将有助于该中心资助一些教育和外展任务，因为 以及其试点赠款计划，旨在扩大Emory的PD研究。