Udall Parkinson's Disease Research Center at Emory University

埃默里大学尤德尔帕金森病研究中心

基本信息

批准号：
9196040
负责人：
Thomas N Wichmann
金额：
$ 141.42万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9196040
关键词：
Address Administrator Adverse effects Affect Algorithms American Anatomy Animals Antiparkinson Agents Area Assisted Living Facilities Basal Ganglia Basic Science Behavior Behavior Control Brain Caregivers Cell Nucleus Cells Cerebrum Child Clinic Clinical Clinical Sciences Collaborations Communities Community Outreach Complement Data Analyses Deep Brain Stimulation Development Disease Education Education and Outreach Educational Activities Educational process of instructing Electron Microscopy Fostering Foundations Functional disorder Funding Future Teacher General Population Goals Grant Head High School Student Human Resources Immunohistochemistry Institutes Institution Journals K-12 student Knowledge Life Light Link Mission Modeling Monkeys Motivation Movement Disorders Neurosciences Parkinson Disease Parkinsonian Disorders Patients Pattern Physiology Population Primates Recommendation Research Research Activity Research Personnel Research Project Grants Research Support Resources Rodent Role Scientist Series Services Slice Social Workers Societies Stream Structure Students Synapses Thalamic structure Therapeutic Intervention Time Tissue Sample Training Training Programs Translational Research Translations United States National Institutes of Health Universities Work age group career career development clinical care clinical movement disorder collaborative environment data sharing design education research experience in vivo innovation insight interest intervention effect laboratory experience meetings motor control neuroregulation outreach outreach program programs relating to nervous system research study retiree science education symposium web site

Address Administrator Adverse effects Affect Algorithms American Anatomy Animals Antiparkinson Agents Area Assisted Living Facilities Basal Ganglia Basic Science Behavior Behavior Control Brain Caregivers Cell Nucleus Cells Cerebrum Child Clinic Clinical Clinical Sciences Collaborations Communities Community Outreach Complement Data Analyses Deep Brain Stimulation Development Disease Education Education and Outreach Educational Activities Educational process of instructing Electron Microscopy Fostering Foundations Functional disorder Funding Future Teacher General Population Goals Grant Head High School Student Human Resources Immunohistochemistry Institutes Institution Journals K-12 student Knowledge Life Light Link Mission Modeling Monkeys Motivation Movement Disorders Neurosciences Parkinson Disease Parkinsonian Disorders Patients Pattern Physiology Population Primates Recommendation Research Research Activity Research Personnel Research Project Grants Research Support Resources Rodent Role Scientist Series Services Slice Social Workers Societies Stream Structure Students Synapses Thalamic structure Therapeutic Intervention Time Tissue Sample Training Training Programs Translational Research Translations United States National Institutes of Health Universities Work age group career career development clinical care clinical movement disorder collaborative environment data sharing design education research experience in vivo innovation insight interest intervention effect laboratory experience meetings motor control neuroregulation outreach outreach program programs relating to nervous system research study retiree science education symposium web site

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项目摘要

The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson's Disease Research at Emory University is a collaborative research program in which electrophysiologists and anatomists study the pathophysiology of parkinsonism, and examine and optimize the effects of existing treatments for Parkinson's disease. The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct translational research. Other Udall Center assets are its close ties to the clinical movement disorders group at Emory, and the availability of primates for research at the Yerkes National Primate Research Center at Emory University. Emory is strongly committed to the Udall Center's research, and supports the Center by funding pilot grants, invited speakers, and portions of its education and outreach programs. The Center consists of three tightly linked projects and two cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes in thalamus and cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize existing neuromodulation strategies and to develop new ones. Project 1 (led by Dr. Jaeger) will utilize brain slice and in vivo recordings in rodents, as well as a neural computational approach to develop mechanistic models of thalamocortical dysfunction in parkinsonism. Project 2 (Dr. Wichmann), will continue the exploration of thalamic and cortical abnormalities in parkinsonian monkeys, using selective activation and inactivation approaches which are designed to study corticothalamic, pallidothalamic and thalamocortical information transfer. Project 3 (Dr. Smith) will examine morphological changes in the thalamic and cortical microcircuitry in parkinsonian primates, a topic that is virtually unexplored at this time and of high relevance to the interpretation of data in the other projects. All projects will be supported by an Administrative Core (Dr. Wichmann, PI; Dr. DeLong, Co-I, Dr. Smith, Co-I, Ms Holbrook, administrator), and by an Anatomy and Behavior Core (Dr. Galvan) which will provide immunohistochemistry and electron microscopy services to all of the center projects, and standardized MPTP treatment and quantification of parkinsonism to the primate experiments in Projects 2 and 3. In addition to pursuing its research mission (Aim 1), the Center will help junior scientists to develop their career in Parkinson's disease research (Aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center's (and Udall Center network) research findings to the public (Aim 3), reaching all age groups and background levels, ranging from K-12 children to retirees in assisted living facilities. As part of the outreach agenda, the center plans to organize annual symposia for patients and their caregivers. The center will be generously supported by the University. These internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand Parkinson's disease research at Emory University.

埃默里大学（Emory University）的莫里斯·K·乌达尔·帕金森（Morris K.该中心借鉴了埃默里（Emory）基底神经节研究界进行转化研究的良好能力。其他UDALL中心资产是与埃默里（Emory）的临床运动障碍小组的密切联系，以及在埃默里大学（Emory University）的Yerkes国家灵长类动物研究中心提供的研究灵长类动物的可用性。埃默里（Emory）强烈致力于Udall中心的研究，并通过资助飞行员赠款，受邀演讲者以及部分教育和外展计划来支持该中心。该中心由三个紧密联系的项目和两个核心组成。计划的研究将阐明丘脑和皮质中与帕金森氏症相关的活动变化，这反过来又将帮助我们更好地了解帕金森氏症的病理生理学，并优化现有的神经调节策略并制定新的神经调节策略。项目1（由Jaeger博士领导）将利用啮齿动物中的脑切片和体内记录，以及一种神经计算方法，用于开发帕金森氏症丘脑皮质功能障碍的机械模型。项目2（Wichmann博士）将继续使用选择性激活和灭活方法来探索帕金森尼猴子中丘脑和皮质异常的探索，这些方法旨在研究皮质丘脑，pallidototothalamic和thalamoforical Information Crossion转移。项目3（史密斯博士）将检查帕金森氏症灵长类动物的丘脑和皮质微环路的形态变化，这个话题实际上尚未探索，并且与其他项目中数据的解释具有很高的相关性。 All projects will be supported by an Administrative Core (Dr. Wichmann, PI; Dr. DeLong, Co-I, Dr. Smith, Co-I, Ms Holbrook, administrator), and by an Anatomy and Behavior Core (Dr. Galvan) which will provide immunohistochemistry and electron microscopy services to all of the center projects, and standardized MPTP treatment and quantification of parkinsonism to the primate experiments in Projects 2 and 3. In addition to pursuing该中心的研究任务（AIM 1）将帮助初级科学家在帕金森氏病研究（AIM 2）中发展职业，并将从事广泛的外展工作，旨在向中心（和Udall Center网络）的研究结果传达给公众（AIM 3）（AIM 3）（AIM 3），从所有年龄段和背景级别上，从K-12儿童到退休儿童，以帮助养活生活的生活。作为外展议程的一部分，该中心计划为患者及其护理人员组织年度研讨会。该中心将得到大学的慷慨支持。这些内部支持资金将有助于该中心资助其一些教育和外展任务，以及其试点赠款计划，旨在扩大埃默里大学的帕金森氏病研究。