Energetics, Disparities, & Lifespan: A unified hypothesis

能量、差异、

基本信息

批准号：
9068744
负责人：
DAVID B ALLISON
金额：
$ 72.79万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-15 至 2017-08-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9068744
关键词：
Affect African American Age Aging Aging-Related Process Animal Feed Animal Model Animals Appetite Depressants Biological Clocks Body Temperature Body Weight decreased Body fat Breeding Buffers Caloric Restriction Chronic Control Animal Data Developed Countries Disadvantaged Eating Economics Energy Intake Environment Evolution Fatty acid glycerol esters Feeling Food Food Energy Genetic Growth Health Hispanic Americans Hispanics Human Hunger Individual Investigation Knowledge Lead Life Link Longevity Maintenance Metabolism Methods Modeling Nature Obesity Older Population Organism Outcome Output Pathway interactions Perception Persons Physiological Policies Population Positioning Attribute Predatory Behavior Process Public Health Quality of life Randomized Reaction Regulation Reproduction Research Research Personnel Rosa Schedule Security Self Perception Social status Socioeconomic Status Specific qualifier value Stimulus System Taxation Temperature Testing Thinking Time Uncertainty Work classical conditioning exhaust experience fitness follow-up health disparity healthy aging improved low socioeconomic status mathematical theory mimetics mortality neuronal cell body novel reproductive research study response senescence social socioeconomic disparity theories

项目摘要

DESCRIPTION (provided by applicant): The evolution and ontogeny of lifespan at the species and individual level, the energetics of the organism in its environment, the storage of metabolizable energy as body fat, and socioeconomic disparities within populations all seem intricately related and yet the nature of these interrelations is poorly understood. Indeed questions as fundamental as why we age remain open and subsidiary questions such as why caloric restriction leads to increased lifespan and why lower socioeconomic status is related to obesity in developed countries also remain unanswered. Herein, we propose a unified model informed by evolutionary thinking about life strategies which connects these phenomena. In this model, aging or more precisely senescence is not something that passively happens to us as the result of environmental insults or from metabolizing fuel, but is something we do. That is, mortality rate or the rate of aging is seen as (partially) internally regulable phenomenon much like the control of body temperature in homeotherms in which the regulated rate is responsive to perceptions about the energetic state of the environment. From this perspective, it is perceptions of the energetic security of the environment that are a key factor in linking these phenomena. We elaborate this theory herein and from it derive seven specific hypotheses, each of which is testable in a different experiment using model organisms. We have assembled a team of the world's leading researchers to conduct these seven experiments and then to conduct follow-up work to study both a priori specified potential causal mechanisms involving internal clock regulation and also to conduct exploratory work to identify new potential mechanisms. Outcomes from this work will have profound implications for our understanding of the nature of aging, of health disparities, and of obesity.

描述（由申请人提供）：物种和个体水平的生命周期的演变和个体发育，生物体在其环境中的能量学，可代谢能量作为体内脂肪的存储以及人口中的社会经济差异都很复杂，但这些相互关系的性质却很熟悉。确实，我们的年龄保持开放和子公司问题，例如为什么热量限制会导致寿命增加，以及为什么较低的社会经济地位与发达国家的肥胖有关，也没有得到答复。在此，我们提出了一个统一的模型，该模型是通过对生活策略的进化思考来告知的，这些策略将这些现象联系起来。在这种模型中，由于环境侮辱或代谢燃料而导致的衰老或更精确的衰老并不是被动地发生的事情，而是我们要做的。也就是说，死亡率或衰老率被视为（部分）内部可调节的现象，就像控制受调节速率对环境能量状态的感知有响应的主管中体温的控制。从这个角度来看，人们对环境的能量安全性的看法是将这些现象联系起来的关键因素。我们在此阐述了这一理论，并从中得出了七个特定的假设，每个假设都可以在使用模型生物的不同实验中测试。我们召集了一个世界领先的研究人员团队进行这七个实验，然后进行后续工作，以研究涉及内部时钟调节的先验特定的潜在因果机制，并进行探索性工作以识别新的潜在机制。这项工作的结果将对我们对衰老，健康差异和肥胖的本质的理解产生深远的影响。