Beyond textbook, yet simple, statistical tools for reproducible animal research

超越教科书的简单统计工具，用于可重复的动物研究

基本信息

批准号：
9142329
负责人：
DAVID B ALLISON
金额：
$ 6.91万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-10 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9142329
关键词：
Address Advocate American Animal Experimentation Animals Basic Science Biometry Characteristics Collaborations Communication Communities Complex Consult Country Crossover Design Data Education Educational Materials Educational process of instructing Equation Evaluation Experimental Designs Face Failure Fostering Health Human Human Resources Immersion Investigative Technique Intervention Investigation Knowledge Laboratories Laboratory Animals Laboratory Research Laboratory Scientists Learning Measures Methods Mission Modeling National Institute of General Medical Sciences Natural Sciences Paper Postdoctoral Fellow Procedures Protocols documentation Publishing Randomized Reading Recommendation Reproducibility Research Research Design Research Misconduct Research Personnel Resources Science Scientist Self Assessment Statistical Data Interpretation Testing Textbooks Training Training Activity Translating Uncertainty United States National Institutes of Health Woman Writing career cost design experience experimental analysis graduate student help-seeking behavior improved innovation laboratory experience learning materials men next generation research study statistics tool web portal web site

项目摘要

DESCRIPTION (provided by applicant): The capacity of laboratory animal research to be translated to interventions for human health is dependent on research reproducibility, replicability, and generalizability (RRG). It is often the case that challenges with RRG arise from differences in scientific protocols, unknown or uncontrolled confounding factors, incomplete communication of scientific protocols, and unintentional misapplication of statistical principles, rather than the oft-discussed research misconduct. Many of these challenges with RRG involve practical and theoretical aspects of statistics and study design that go beyond what is taught in basic statistics courses or textbooks. We therefore propose creating a set of animated vignettes to educate early career, laboratory animal investigators (namely, graduate students, postdoctoral fellows, and beginning investigators) about these issues. We specifically propose modules on variability, power, randomization, hypothesis testing, and inferences that address common, and yet not routine-textbook needs of laboratory researchers. Each module will be composed of several short, animated vignettes that will 1) discuss a statistical or design principle that is important for RRG; 2) foster dialogue and collaboration between statistical and laboratory animal scientists; and 3) model diversity of statistical and laboratory animal scientist with respect to expertise and demographic characteristics. Each vignette will also be evaluated for content validity, face validity, and educational value by consulting with statistical experts, experienced lab animal researchers, and early career investigators, respectively. Finally, vignettes will be reinforced with additional online instructional content, including tutorial literture and self-assessment quizzes. Our team will widely disseminate the instructional materials leveraging our experience and resources creating and sharing online educational content, and we commit to maintain the materials in an openly available web portal without cost to end users. By supporting principles of RRG in this way, we contribute broadly to the mission of the NIH in fostering fundamental creative discoveries, innovative research strategies, and their applications; developing, maintaining, and renewing scientific human resources; and exemplifying and promoting the highest level of scientific integrity in the conduct of science. We specifically contribute to the mission of the NIGMS by "training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country."

描述（由适用提供）：将实验室动物研究转化为人类健康干预措施的能力取决于研究可重复性，可复制性和概括性（RRG）。 rrg挑战通常是从科学方案，未知或不受控制的混杂因素，科学方案的不完整交流以及对统计原理的无意化误解，而不是经常讨论的研究失误的差异。 RRG的许多挑战都涉及统计和研究设计的实践和理论方面，这些方面超出了基本统计课程或教科书中所教的内容。因此，我们建议创建一套动画小插曲来教育早期职业，实验室动物调查人员（即研究生，博士后研究员和开始研究人员）就这些问题进行研究。我们专门提出了有关可变性，功率，随机化，假设检验的模块，以及针对常见的推论，但不是实验室研究人员的常规文本书籍需求。每个模块将由几个简短的动画小插图组成，它们将1）讨论对RRG重要的统计或设计原理； 2）在统计和实验室动物科学家之间培养对话和合作； 3）模拟统计和实验室动物科学家在专业知识和人口特征方面的多样性。每个小插图还将分别与统计专家，经验丰富的实验室动物研究人员和早期职业研究人员进行咨询，以评估内容有效性，面部有效性和教育价值。最后，Vignettes将通过其他在线教学内容（包括教程文献和自我评估测验）加强。我们的团队将广泛传播利用我们的经验和资源创建和共享在线教育内容的教学材料，我们致力于将材料维护在公开可用的Web门户网站中，而无需最终用户。通过以这种方式支持RRG的原则，我们为NIH的使命做出了广泛的贡献，以促进基本创意发现，创新的研究策略及其应用；发展，维持和更新科学人力资源；并典范和促进科学行为的最高科学完整性。我们通过“训练下一代科学家，在增强科学劳动力的多样性以及在全国发展研究能力方面。”