StuDy AimED at Increasing AlCohol AbsTinEnce (DEDICATE)

旨在提高酒精戒断率的研究（奉献）

• 批准号: 10577022
• 负责人: Hagar Hallihan
• 金额: $ 18.6万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577022
• 关键词: Advanced Development; Affect; African American; Aftercare; Age; Alcohol consumption; Alcohol dependence; Alcohols; Amygdaloid structure; Award; Behavior Therapy; Benchmarking; Brain region; Brief Psychotherapy; Chronic Disease; Client satisfaction; Clinical Research; Collaborations; Competence; Complement; Data; Data Analyses; Data Collection; Disease; Elderly; Enrollment; Ensure; Environment; Evaluation; Evidence based treatment; Female; Focus Groups; Functional Magnetic Resonance Imaging; Future; Goals; Health; Impairment; Individual; Institution; Intervention; Intervention Trial; Interview; Knowledge; Leadership; Life; Mediating; Mentors; Mentorship; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Neurosciences; Outcome; Participant; Persons; Phase; Positioning Attribute; Prefrontal Cortex; Prevention; Protocols documentation; Public Health; Qualitative Research; Questionnaires; Randomized; Randomized, Controlled Trials; Recommendation; Research; Research Methodology; Research Personnel; Research Training; Rewards; Science; Senior Scientist; Smoking; Structure; Symptoms; System; Target Populations; Testing; Therapeutic Intervention; Training; Treatment Efficacy; Urine; Ventral Striatum; Woman; acceptability and feasibility; age group; aged; alcohol abstinence; alcohol abuse therapy; alcohol screening; alcohol use disorder; arm; behavioral clinical trial; behavioral study; brain dysfunction; clinically relevant; cognitive control; contingency management; cost; design; effective therapy; effectiveness evaluation; efficacy evaluation; efficacy testing; experience; feasibility testing; follow-up; functional MRI scan; high risk drinking; improved; innovation; male; meetings; motivational enhancement therapy; negative affect; neural; neural circuit; neuroimaging; neuromechanism; patient population; pilot trial; primary outcome; problem solving therapy; programs; randomized, clinical trials; reduced alcohol use; remote delivery; reward circuitry; satisfaction; skills; therapy design; therapy development; treatment effect; videoconference; young adult

PROJECT SUMMARY/ABSTRACT The long-term objective of this award is to support Dr. Hagar Hallihan, an African American woman, in advanced training in clinical research and neuroscience and establishing an independent research program. Her research program focuses on developing clinically relevant and effective integrated behavioral interventions to improve treatment efficacy and better understand the neuro mechanism of treatment for young adults with alcohol use disorder (AUD). Her mentorship team is a transdisciplinary group of senior scientists with research expertise in behavioral clinical trials, behavioral intervention development, AUD in young adults, neuroimaging data, and quantitative and qualitative research methods. She will continue working with her current T32 mentor, Dr. Ma, a senior scientist with extensive experience mentoring trainees. This will be complemented by content and mentoring expertise from Drs. Ajilore, Rospenda, and Wu. Collectively, this team will provide an outstanding training environment that will allow Dr. Hallihan to fill critical gaps in her knowledge and skill set relating to the study of behavior interventions and neural mechanisms underlying treatment for young adults with AUD. Her training goals are to develop skills in (1) designing and assessing effectiveness of mechanistic randomized clinical trials, (2) competency in statistical and fMRI data analyses, and (3) knowledge and skills in the neurobiology of alcohol addiction. In addition, she will develop professional skills in scientific leadership and interdisciplinary team science. Achieving these goals will strengthen her scholarly activities, establish important collaborations, and acquire critical data that will ensure her successful transition to independence. The proposed research plan builds on Dr. Hallihan’s prior research training in AUD among young adults. AUD, a chronic disease of impaired ability to stop or control alcohol use, is a costly major public health problem, most prevalent in young adults (aged18-24 yr). Heavy alcohol consumption impairs brain structure and function, more severely in young adults than in older adults. However, evidence-based treatments for AUD in young adults are lacking, and the neural mechanisms following available behavior treatments are poorly understood. The aims of the K99 phase are (1) to develop an integrated contingency management (CM) and Problem-Solving Therapy (PST), CM-PST intervention to improve alcohol abstinence among young adults with AUD, and (2) test feasibility and acceptability of the intervention. The aims of the R00 phase are to (1) test the efficacy of CM-PST vs CM alone in a 2-arm pilot RCT, and (2) assess neural mechanisms associated with CM-PST treatment effects in young adults with AUD. Support from this award will enable Dr. Hallihan to launch an independent program of research that contributes to the field by 1) developing and implementing an innovative intervention to improve alcohol abstinence among young adults with AUD, and 2) assess neural mechanisms of successful treatment among young adults with AUD to inform future intervention and prevention efforts and ultimately reduce the public health burden of AUD.

项目摘要/摘要 该奖项的长期目标是支持非洲裔美国妇女Hagar Hallihan博士 临床研究和神经科学的高级培训并建立独立的研究计划。 她的研究计划着重于发展临床相关且有效的综合行为 提高治疗效率的干预措施并更好地了解年轻的神经治疗机制 患有饮酒障碍的成年人（AUD）。她的Mentalship团队是一个跨学科的高级科学家小组 具有行为临床试验，行为干预发展，年轻人的研究专业知识， 神经影像学数据以及定量和定性研究方法。她将继续与她合作 当前的T32心态，MA博士，一位高级科学家，拥有丰富经验的心理学员。这将是 由DRS的内容和心理专业知识完成。 Ajilore，Rospenda和Wu。总的来说，这 团队将提供出色的培训环境，使Hallihan博士能够填补她的关键空白 与研究行为干预措施和神经机制有关的知识和技能集 对年轻人的治疗。她的培训目标是发展（1）设计和评估的技能 机械随机临床试验的有效性，（2）统计和fMRI数据分析的能力， （3）酒精成瘾神经生物学的知识和技能。此外，她将发展专业 科学领导力和跨学科团队科学的技能。实现这些目标将增强她 学术活动，建立重要的合作并获得关键数据，以确保她成功 过渡到独立。拟议的研究计划是基于Hallihan博士在AUD的先前研究培训的基础 在年轻人中。 aud是一种慢性疾病的停止或控制饮酒的能力受损，这是一个昂贵的主要专业 公共卫生问题，最普遍的年轻人（18-24岁）。大量饮酒障碍 大脑结构和功能，年轻人比老年人更严重。但是，基于证据 缺乏年轻人的AUD治疗方法，以及可用行为后的神经机制 治疗知之甚少。 K99阶段的目的是（1）发展综合意外情况 管理（CM）和解决问题的疗法（PST），CM-PST干预以改善酒精戒烟 在具有AUD的年轻人中，以及（2）测试干预的可行性和可接受性。 R00的目的 阶段是（1）在2臂驾驶员RCT中仅测试CM-PST与CM的效率，并且（2）评估中性 AUD的年轻人与CM-PST治疗效应相关的机制。该奖项的支持将 使Hallihan博士能够启动一个独立的研究计划，该计划通过1）开发为该领域做出贡献 并实施创新的干预措施，以改善具有AUD的年轻人的戒酒， 2）评估有AUD的年轻人成功治疗的神经机制，以告知未来 干预和预防努力，最终减少了AUD的公共卫生燃烧。