Binge Eating as a Mechanism Underlying the Food Insecurity-Obesity Paradox in Adolescents

暴饮暴食是青少年粮食不安全-肥胖悖论的潜在机制

基本信息

批准号：
10583732
负责人：
Vivienne M Hazzard
金额：
$ 11.89万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10583732
关键词：
Accounting Adolescence Adolescent Adolescent obesity Adult Affect Area Award Behavior Beverages Binge Eating Body mass index Child Data Decision Trees Development Dietary Factors Dietitian Eating Energy consumption Etiology Face Feedback Feeling Food Funding General Population Goals Household Intervention Interview Knowledge Longitudinal Studies Machine Learning Mediating Mediation Mediator Mental Health Mentors Mentorship Methods Minnesota Morbidity - disease rate Nutrient Obesity Outcome Pathway interactions Pattern Phase Premature Mortality Prevalence Public Health Qualitative Research Reporting Research Research Personnel Resources Risk Risk Factors Role Sampling Schools Statistical Methods Statistical Models Strategic Planning Structure Subgroup Techniques Testing Time Training Trees United States United States National Institutes of Health Universities Weight Weight Gain Work Youth career cohort excessive weight gain experience food insecurity food security healthy weight high body mass index human centered design improved innovation marginalized population novel obesity prevention obesity risk physical conditioning population based prevent recruit response therapy design therapy development young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Food insecurity is paradoxically associated with elevated risk of adolescent obesity in the United States. The mechanisms underlying this excess risk are not well understood, and such knowledge is essential for informing obesity prevention efforts for adolescents from under-resourced backgrounds. Thus, aligned with the need emphasized by the Strategic Plan for NIH Obesity Research to identify the reasons contributing to increased risk for obesity among economically marginalized populations, research is critically needed to elucidate modifiable mechanisms to target in obesity prevention efforts among food-insecure adolescents. In the proposed project, Dr. Hazzard, a registered dietitian and public health researcher, will examine binge eating as a potential mechanism to explain the association between food insecurity and elevated risk for adolescent obesity. With the exceptional mentorship team she has assembled and the resources available to her through the University of Minnesota, this Pathway to Independence Award will support Dr. Hazzard in filling critical training gaps and conducting the research necessary to launch her career as an independent investigator conducting intervention work to promote food security and healthy weight among adolescents experiencing food insecurity. To prepare her for this role, a multifaceted training plan including coursework, mentorship, and research is proposed in: (1) qualitative and mixed methods, (2) advanced statistical methods, with a focus on machine learning and causal mediation analysis, and (3) intervention design, development, and dissemination, with an emphasis on human- centered design. The expertise Dr. Hazzard develops through this training plan will be essential for conducting the proposed research. During the mentored K99 phase, she will elucidate the etiology of binge eating in the context of food insecurity during adolescence using a mixed-methods approach that involves (a) conducting qualitative interviews in food-insecure adolescents who report binge eating and (b) leveraging existing data from an NIH-funded observational cohort to employ tree-based machine learning techniques (Aim 1). In the independent R00 phase, Dr. Hazzard will recruit 175 adolescents into a new, independent cohort that she will follow for 18 months to quantify the extent to which binge eating mediates the longitudinal association between food insecurity and weight gain during adolescence (Aim 2). Finally, using a human-centered design approach, she will develop vignettes describing potential school-based interventions to improve food security and prevent excess weight gain among food-insecure adolescents and assess perceived acceptability of the potential interventions using these vignettes in semi-structured interviews with adolescents who have experienced food insecurity (Aim 3). Findings from this project will lay the groundwork for the development and implementation of a school-based intervention to promote food security and healthy weight among adolescents experiencing food insecurity and, in turn, promote Dr. Hazzard’s successful transition to an independent research career. 1

项目概要/摘要矛盾的是，粮食不安全与美国青少年肥胖风险升高相关。这种过度风险背后的机制尚未得到很好的理解，而这些知识对于告知信息至关重要因此，针对资源贫乏背景的青少年的肥胖预防工作符合需求。 NIH 肥胖研究战略计划强调确定导致风险增加的原因对于经济弱势群体的肥胖问题，迫切需要研究来阐明可改变的方法针对粮食不安全青少年的肥胖预防工作的机制在拟议的项目中，哈扎德博士是一名注册营养师和公共卫生研究员，他将把暴饮暴食视为一种潜在的疾病解释粮食不安全与青少年肥胖风险升高之间关系的机制。她组建了出色的导师团队，并通过大学为她提供了资源明尼苏达州，该独立之路奖将支持哈扎德博士填补关键的培训空白和进行必要的研究以开启她作为独立调查员的职业生涯进行干预努力促进面临粮食不安全的青少年的粮食安全和健康体重。对于这个角色，我们提出了一个多方面的培训计划，包括课程作业、指导和研究：(1) 定性和混合方法，（2）先进的统计方法，重点是机器学习和因果关系中介分析，以及（3）干预设计、开发和传播，重点是人哈扎德博士通过该培训计划获得的专业知识对于进行该设计至关重要。在拟议的 K99 指导阶段，她将阐明暴食的病因。使用混合方法应对青春期粮食不安全的情况，其中包括：(a) 对报告暴饮暴食的粮食不安全青少年进行定性访谈，并且 (b) 利用来自 NIH 资助的观察队列采用基于树的机器学习技术（目标 1）。在独立 R00 阶段，哈扎德博士将招募 175 名青少年加入一个新的独立队列，她将跟踪 18 个月，以量化暴食在多大程度上介导两者之间的纵向关联最后，采用以人为本的设计方法，她将编写一些小插曲，描述潜在的基于学校的干预措施，以改善粮食安全和预防食物不安全的青少年体重增加过多，并评估其潜在的可接受性使用这些小插曲对经历过食物的青少年进行半结构化访谈进行干预该项目的调查结果将为制定和实施奠定基础。以学校为基础的干预措施，以促进青少年的粮食安全和健康体重不安全感，反过来又促进哈扎德博士成功过渡到独立研究生涯。 1