Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure

有氧运动、神经营养素以及海马功能和结构的功能磁共振成像

基本信息

批准号：
8639187
负责人：
Karin Schon
金额：
$ 24.5万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8639187
关键词：
Adult Aerobic Aerobic Exercise Aging Alzheimer&apos s Disease Animal Experimentation Animal Model Area Behavior Behavioral Blood Brain Brain-Derived Neurotrophic Factor Cardiovascular system Clinical Clinical Psychology Clinical Trials Design Cognition Cognitive Control Groups Cross-Sectional Studies Doctor of Medicine Doctor of Philosophy Elderly Exercise Exercise Physiology Face Functional Magnetic Resonance Imaging Functional disorder Funding Goals Grant Health Hippocampus (Brain)Human Image Impaired cognition Individual Intervention Knowledge Link Longevity Magnetic Resonance Imaging Measurement Measures Medial Memory Mentors Methods Movement Disorders Names Neuroanatomy Neurology Neuropsychology Neurorehabilitation Outcome Outcome Measure Paired-Associate Learning Pathway interactions Performance Phase Pre-Post Tests Prefrontal Cortex Randomized Recruitment Activity Research Resolution Role Sampling Scanning Scientist Serum Short-Term Memory Structure Task Performances Temporal Lobe Testing Thick Training Weight Work base behavior test career cognitive neuroscience cost design fitness flexibility healthy aging improved interest long term memory memory recognition neuroimaging neuropsychological neurotrophic factor physical conditioning primary outcome professor programs research study sedentary young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The research proposed in this Pathways grant identifies and seeks to fill a current gap in knowledge regarding the relationship between aerobic exercise and cardiovascular fitness and functional and structural brain health in humans. The proposed human neuroimaging studies build upon a large body of existing animal research, and aim to extend this work to humans. The candidate is interested in establishing an independent research career in which she can study the effects of aerobic exercise and cardiovascular fitness on cognition and brain health in humans across the lifespan. The candidate's past and current research has included functional Magnetic Resonance Imaging (fMRI) studies of interactions between working memory and long-term memory and the role of the medial temporal lobes (including the hippocampus) and prefrontal cortex in working memory. The overall goal of this proposal is to prepare the candidate for a career as an independent scientist in translational cognitive neuroscience. Mentors include Dr. Chantal E. Stern, D.Phil., an expert in the cognitive neuroimaging of memory, Dr. Robert C. Wagenaar, Ph.D., a professor of exercise physiology and neurorehabilitation who is known for his work on movement disorders, Dr. Andrew E. Budson, M.D., an expert in cognitive and behavioral neurology, who is known for his work on cognitive dysfunction and memory dysfunction in Alzheimer's Disease, and Dr. Alice Cronin-Golomb, Ph.D. a professor of clinical psychology and an expert in the neuropsychology of aging. The goals of the research plan are to 1) establish a link between aerobic exercise, cardiovascular fitness, the functional neuroanatomy of hippocampal-dependent memory, and a neurotrophin, the Brain-Derived Neurotrophic Factor (BDNF) in humans using two memory tasks and fMRI (Specific Aim #1), 2) investigate whether a 12-week aerobic exercise intervention in healthy young and older sedentary adults is associated with an improvement in memory task performance, increased serum BDNF levels, and enhanced task-related hippocampal activity using fMRI and a pretest-posttest randomized control group design (Specific Aim #2), and 3) investigate whether the same aerobic exercise intervention in healthy young and older sedentary individuals results in increased volume in the hippocampus and/or hippocampal subfields, and cortical thickness in other brain areas using structural MRI and morphometric methods. The candidate will acquire essential training in exercise physiology and neurorehabilitation, geriatric neurology, clinical neuropsychological assessment, morphometric analyses of structural MRI images, and in clinical trial design. The project will enable the candidate to establish an externally funded research program in translational cognitive neuroscience. Aerobic exercise may be an effective and low-cost intervention resulting in healthy aging by promoting not only physical health, but also brain health. Regular moderate intensity aerobic exercise may have neuroprotective effects throughout the lifespan.

项目概要/摘要该途径资助中提出的研究确定并寻求填补当前的知识空白有氧运动与心血管健康以及大脑功能和结构健康之间的关系在人类中。拟议的人类神经影像研究建立在大量现有动物研究的基础上，并旨在将这项工作扩展到人类。候选人有兴趣建立独立研究她可以研究有氧运动和心血管健康对认知和大脑的影响人类整个生命周期的健康。候选人过去和当前的研究包括功能性工作记忆和长期记忆之间相互作用的磁共振成像（fMRI）研究以及内侧颞叶（包括海马体）和前额皮质在工作中的作用记忆。该提案的总体目标是让候选人为独立科学家的职业生涯做好准备在转化认知神经科学中。导师包括 Chantal E. Stern 博士，哲学博士，他是该领域的专家记忆的认知神经成像，运动生理学教授 Robert C. Wagenaar 博士神经康复专家 Andrew E. Budson 博士，医学博士，因其在运动障碍方面的研究而闻名认知和行为神经学博士，以其在认知功能障碍和记忆方面的研究而闻名阿尔茨海默病的功能障碍，以及 Alice Cronin-Golomb 博士。临床心理学教授和衰老神经心理学专家。研究计划的目标是 1) 在有氧运动、心血管健康、海马依赖性记忆的功能神经解剖学，以及一种神经营养素，即人类使用两项记忆任务和功能磁共振成像的脑源性神经营养因子 (BDNF) （具体目标#1），2）调查是否对健康的年轻人和老年人进行为期 12 周的有氧运动干预久坐的成年人与记忆任务表现的改善、血清 BDNF 的增加有关水平，并使用功能磁共振成像和前后测试随机对照增强与任务相关的海马活动小组设计（具体目标#2）和 3）调查是否在健康人群中进行相同的有氧运动干预年轻人和老年人久坐会导致海马体和/或海马体体积增加使用结构 MRI 和形态测量方法测量其他大脑区域的子区域和皮质厚度。这候选人将获得运动生理学和神经康复、老年神经学、临床神经心理学评估、结构 MRI 图像的形态测量分析以及临床试验设计。该项目将使候选人能够建立一个外部资助的研究项目转化认知神经科学。有氧运动可能是一种有效且低成本的干预措施不仅促进身体健康，而且促进大脑健康，从而促进健康老龄化。定期中等强度有氧运动可能在整个生命周期中具有神经保护作用。