Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
有氧运动、神经营养素以及海马功能和结构的功能磁共振成像
基本信息
- 批准号:8043800
- 负责人:
- 金额:$ 8.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-30 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The research proposed in this Pathways grant identifies and seeks to fill a current gap in knowledge regarding the relationship between aerobic exercise and cardiovascular fitness and functional and structural brain health in humans. The proposed human neuroimaging studies build upon a large body of existing animal research, and aim to extend this work to humans. The candidate is interested in establishing an independent research career in which she can study the effects of aerobic exercise and cardiovascular fitness on cognition and brain health in humans across the lifespan. The candidate's past and current research has included functional Magnetic Resonance Imaging (fMRI) studies of interactions between working memory and long-term memory and the role of the medial temporal lobes (including the hippocampus) and prefrontal cortex in working memory. The overall goal of this proposal is to prepare the candidate for a career as an independent scientist in translational cognitive neuroscience. Mentors include Dr. Chantal E. Stern, D.Phil., an expert in the cognitive neuroimaging of memory, Dr. Robert C. Wagenaar, Ph.D., a professor of exercise physiology and neurorehabilitation who is known for his work on movement disorders, Dr. Andrew E. Budson, M.D., an expert in cognitive and behavioral neurology, who is known for his work on cognitive dysfunction and memory dysfunction in Alzheimer's Disease, and Dr. Alice Cronin-Golomb, Ph.D. a professor of clinical psychology and an expert in the neuropsychology of aging. The goals of the research plan are to 1) establish a link between aerobic exercise, cardiovascular fitness, the functional neuroanatomy of hippocampal-dependent memory, and a neurotrophin, the Brain-Derived Neurotrophic Factor (BDNF) in humans using two memory tasks and fMRI (Specific Aim #1), 2) investigate whether a 12-week aerobic exercise intervention in healthy young and older sedentary adults is associated with an improvement in memory task performance, increased serum BDNF levels, and enhanced task-related hippocampal activity using fMRI and a pretest-posttest randomized control group design (Specific Aim #2), and 3) investigate whether the same aerobic exercise intervention in healthy young and older sedentary individuals results in increased volume in the hippocampus and/or hippocampal subfields, and cortical thickness in other brain areas using structural MRI and morphometric methods. The candidate will acquire essential training in exercise physiology and neurorehabilitation, geriatric neurology, clinical neuropsychological assessment, morphometric analyses of structural MRI images, and in clinical trial design. The project will enable the candidate to establish an externally funded research program in translational cognitive neuroscience. Aerobic exercise may be an effective and low-cost intervention resulting in healthy aging by promoting not only physical health, but also brain health. Regular moderate intensity aerobic exercise may have neuroprotective effects throughout the lifespan.
PUBLIC HEALTH RELEVANCE: Regular moderate intensity aerobic exercise may be an effective and low-cost intervention for healthy aging by promoting not only physical health, but also brain health, and may have neuroprotective effects throughout the lifespan. These effects of exercise on the brain have been studied extensively in animal models, but not in humans. This set of studies aims to examine the relationship between aging, exercise, and the brain in healthy young and older individuals.
描述(由申请人提供):此途径中提出的研究授予确定并试图填补有关有氧运动与心血管健身之间的关系以及人类功能性和结构性脑健康之间关系的当前差距。拟议的人类神经影像学研究以大量现有动物研究为基础,并旨在将这项工作扩展到人类。候选人有兴趣建立独立的研究职业,在该职业中,她可以研究有氧运动和心血管健身对整个生命周期人类认知和脑部健康的影响。候选人的过去和当前研究包括功能性磁共振成像(fMRI)研究工作记忆与长期记忆之间的相互作用以及内侧颞叶(包括海马)和前额叶皮层在工作记忆中的作用。该提案的总体目标是为候选人做好候选人的准备,成为转化认知神经科学领域的独立科学家。导师包括Chantal E. Stern博士,D.Phil。是记忆认知神经影像学专家,Robert C. Wagenaar博士博士,运动生理学和神经疗法教授,以运动障碍的工作而闻名,他的认知和行为神经学专家,他在运动障碍方面的工作,他的工作专家,他的工作专家,他的工作人员是他的工作。在阿尔茨海默氏病和爱丽丝·克罗宁·戈尔姆博士博士学位上临床心理学教授和衰老神经心理学专家。研究计划的目标是1)建立有氧运动,心血管健康,依赖海马的功能性神经解剖学与神经营养蛋白(脑衍生的神经营养因子(BDNF)(BDNF)(BDNF)在人类中使用两个记忆任务和较年轻的运动型(特定目标),以及12周期的效果,以下与使用fMRI和预测的最佳测试随机对照组的设计(特定目标#2)以及3)使用相同的有氧运动的年轻人和老年人的体积,以及在海马型和较高的脑海中增加了同样的有氧运动干预,以及在海马和较高的脑海中增加了相同的有氧运动干预,并研究了与任务的随机对照组设计(特定目标#2)有关,与任务相关的随机对照组设计(特定目标#2)相关的与任务相关的海马活动增强以及与任务相关的海马活动的增强相关,并与HippocaMpus的体积增加相同,以及是否相同和形态学方法。候选人将获得运动生理学和神经康复,老年神经病学,临床神经心理学评估,结构MRI图像的形态计量学分析以及临床试验设计中的基本培训。该项目将使候选人能够建立一项基于转化认知神经科学的外部资助研究计划。有氧运动可能是一种有效且低成本的干预措施,可通过不仅促进身体健康,而且可以促进大脑健康,从而导致健康衰老。常规中等强度有氧运动可能在整个生命周期中具有神经保护作用。
公共卫生相关性:常规中等强度有氧运动可能是通过促进身体健康,而且还可以在整个生命周期内具有神经保护作用来进行健康衰老的有效且低成本的干预措施。运动对大脑的影响已在动物模型中进行了广泛的研究,但在人类中没有进行。这组研究旨在检查健康的年轻人和老年人的衰老,运动与大脑之间的关系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Karin Schon其他文献
Karin Schon的其他文献
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{{ truncateString('Karin Schon', 18)}}的其他基金
Psychosocial stress, cardio-respiratory fitness, and the medial temporal hippocampal system in Black emerging adults
黑人新生成年人的心理社会压力、心肺健康和内侧颞海马系统
- 批准号:
10522292 - 财政年份:2022
- 资助金额:
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Perceived racism, cardiovascular disease risk, and neurocognitive aging
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10667572 - 财政年份:2022
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$ 8.99万 - 项目类别:
Psychosocial stress, cardio-respiratory fitness, and the medial temporal hippocampal system in Black emerging adults
黑人新生成年人的心理社会压力、心肺健康和内侧颞海马系统
- 批准号:
10677874 - 财政年份:2022
- 资助金额:
$ 8.99万 - 项目类别:
Perceived racism, cardiovascular disease risk, and neurocognitive aging
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- 批准号:
10448789 - 财政年份:2022
- 资助金额:
$ 8.99万 - 项目类别:
Psychosocial stressors and the hippocampal memory system in African American seniors
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- 批准号:
9903181 - 财政年份:2019
- 资助金额:
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The entorhinal cortex and aerobic exercise in aging
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- 批准号:
9111578 - 财政年份:2016
- 资助金额:
$ 8.99万 - 项目类别:
The entorhinal cortex and aerobic exercise in aging
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- 批准号:
9325397 - 财政年份:2016
- 资助金额:
$ 8.99万 - 项目类别:
Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
有氧运动、神经营养素以及海马功能和结构的功能磁共振成像
- 批准号:
8639187 - 财政年份:2013
- 资助金额:
$ 8.99万 - 项目类别:
Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
有氧运动、神经营养素以及海马功能和结构的功能磁共振成像
- 批准号:
8643563 - 财政年份:2013
- 资助金额:
$ 8.99万 - 项目类别:
Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
有氧运动、神经营养素以及海马功能和结构的功能磁共振成像
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8149845 - 财政年份:2010
- 资助金额:
$ 8.99万 - 项目类别:
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