Arkansas Integrative Metabolic Research Center

阿肯色州综合代谢研究中心

• 批准号: 10574555
• 负责人: Kyle Patrick Quinn
• 金额: $ 217.52万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10574555
• 关键词: Arkansas; Biochemistry; Bioenergetics; Biological Assay; Biological Sciences; Biomedical Engineering; Biomedical Research; Cells; Centers of Research Excellence; Chemistry; Collaborations; Collection; Complex; Core Facility; Country; Data Science; Data Science Core; Development; Development Plans; Diabetes Mellitus; Disease; Domestic Fowls; Epithelium; Equipment; Exercise; Extramural Activities; Faculty; Flow Cytometry; Foundations; Funding; Genetic Code; Goals; Health; High Performance Computing; Human; Image; Imaging technology; Institution; Interdisciplinary Study; Investments; Label; Lead; Malignant Neoplasms; Medical; Mentors; Mentorship; Metabolic; Metabolism; Methionine Metabolism Pathway; Microscopy; Mission; Mitochondria; Molecular Biology; Morphogenesis; Neoplasm Metastasis; Obesity; Optics; Phase; Pilot Projects; Post-Translational Protein Processing; Radiation Oncology; Research; Research Personnel; Research Project Grants; Resources; Role; Science; Services; Signal Transduction; Spectrum Analysis; Techniques; Technology; Tissues; United States National Institutes of Health; Universities; Veterinary Schools; cancer therapy; college; computer science; computing resources; faculty research; insight; large datasets; malignant breast neoplasm; medical schools; melanoma; member; metabolic imaging; multidisciplinary; nerve supply; new therapeutic target; novel therapeutic intervention; programs; recruit; repaired; synergism; tool

Project Summary for Overall Section of the Arkansas Integrative Metabolic Research Center (AIMRC): The University of Arkansas - Fayetteville (U of A) is the flagship campus of the State of Arkansas, but does not have active NIH COBRE funding on campus. A clear strength in biomedical research has emerged organically on campus, with the majority of NIH funding at the U of A involving research on cell and tissue metabolism. This collection of NIH-funded researchers on campus will initiate and develop a cross-disciplinary research center at the University of Arkansas titled, the Arkansas Integrative Metabolic Research Center (AIMRC). Dr. Kyle Quinn, an established leader in the field of metabolic imaging and biomedical optics, with ongoing collaborations with the other NIH-funded metabolic researchers on campus will direct the center. The scientific theme of the AIMRC is to understand the role of cell and tissue metabolism in disease, development, and repair through research involving advanced imaging, bioenergetics, and data science. By elucidating the complex relationship between metabolism and different disease states using established bioenergetics assays, advanced label-free imaging technology and cutting-edge data science approaches, novel therapeutic targets and mechanistic insights can be identified to establish new treatment approaches for a variety of diseases. The AIMRC will have an administrative core, three research cores, and four research projects led by junior investigator Project Leaders. The Administrative Core will coordinate center activities, oversee the recruitment and mentoring of junior faculty, and coordinate a Pilot Project Program. The AIMRC will invest in existing state-of-the-art microscopy service centers on campus to establish an Imaging and Spectroscopy Core focused on label-free metabolic imaging and spectroscopy. A Bioenergetics Core will employ state-of-the-art live cell metabolic assay platforms in conjunction with established flow cytometry tools to provide quantitative insights into the mitochondrial and metabolic health of the cells. A Data Science Core will also be established by leveraging our high-performance computing resources and expertise on campus to assist researchers with analyzing, integrating, and synthesizing large datasets generated by the research cores and center members. The AIMRC will support four junior faculty members to lead Research Projects to study different aspects of cell and tissue metabolism that include: understanding the mechanisms of breast cancer innervation, evaluating the effects of post-translational modifications in breast cancer, evaluating the effect of methionine metabolism in melanoma, and elucidating cell signaling and mitochondrial dynamics during epithelial morphogenesis. The near-term goal is to follow a center organization and management plan to establish the foundation of the center by recruiting, developing, and mentoring junior investigators. Ultimately, we plan to grow the center to a critical mass of researchers that sustains the center and allows it to be competitive for a wide range of extramural support in metabolic research.

阿肯色州综合代谢研究中心 (AIMRC) 整体部分的项目摘要： 阿肯色大学费耶特维尔分校（U of A）是阿肯色州的旗舰校园，但并不 校园内拥有活跃的 NIH COBRE 资助。生物医学研究的明显优势已有机显现 在校园内，美国国立卫生研究院 (NIH) 的大部分资金都涉及细胞和组织代谢的研究。这 NIH 资助的校园研究人员集合将在 阿肯色大学名为阿肯色综合代谢研究中心（AIMRC）。凯尔·奎因博士， 代谢成像和生物医学光学领域的公认领导者，与 国立卫生研究院资助的校园内其他代谢研究人员将领导该中心。 AIMRC的科学主题 是通过研究了解细胞和组织代谢在疾病、发育和修复中的作用 涉及先进成像、生物能量学和数据科学。通过阐明之间的复杂关系 使用已建立的生物能学测定、先进的无标记成像来评估新陈代谢和不同的疾病状态 技术和尖端数据科学方法、新颖的治疗靶点和机制见解可以 被确定为多种疾病建立新的治疗方法。 AIMRC 将设立一个 行政核心、三个研究核心和四个由初级研究员项目负责人领导的研究项目。 行政核心将协调中心活动，监督初级教师的招聘和指导， 并协调试点项目计划。 AIMRC 将投资现有最先进的显微镜服务 校园中心建立一个成像和光谱核心，专注于无标记代谢成像和 光谱学。生物能量学核心将采用最先进的活细胞代谢测定平台 使用已建立的流式细胞术工具提供对线粒体和代谢健康的定量见解 的细胞。还将利用我们的高性能计算建立数据科学核心 校园资源和专业知识，协助研究人员分析、整合和综合大型 由研究核心和中心成员生成的数据集。 AIMRC 将支持四名初级教师 成员领导研究项目来研究细胞和组织代谢的不同方面，包括： 了解乳腺癌神经支配的机制，评估翻译后的影响 乳腺癌的修饰，评估蛋氨酸代谢对黑色素瘤的影响，并阐明细胞 上皮形态发生过程中的信号传导和线粒体动力学。近期目标是跟随中心 组织和管理计划通过招聘、开发和培训来建立中心的基础 指导初级研究者。最终，我们计划将该中心发展到足够数量的研究人员， 维持该中心并使其在代谢研究领域的广泛外部支持方面具有竞争力。