(2/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities

(2/3) MMC、VICC 和 TSU：消除癌症差异的合作伙伴

• 批准号: 10693353
• 负责人: Tuya Pal
• 金额: $ 150.38万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693353
• 关键词: Address; Area; Award; Awareness; Basic Science; Behavioral; Big Data; Bioinformatics; Bioinformatics Shared Resource; Biological Factors; Biometry; Cancer Center; Cancer Patient; Cancer Research Project; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorectal Cancer; Communities; Community Health; Comprehensive Cancer Center; Development; Discipline; Disparity; Education; Effectiveness; Environment; Equity; Ethnic Origin; Evaluation; Extramural Activities; Faculty; Financial Hardship; Fostering; Geographic Locations; Geography; Goals; Growth; Health Educators; Immunooncology; Incidence; Inequity; Infrastructure; Institution; Intervention Trial; Lead; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical Students; Minority; Minority-Serving Institution; Mission; Oncology; Outcome; Pathology; Pathway interactions; Patient Participation; Peer Review; Population Research; Population Sciences; Prevalence; Publications; Race; Reduce health disparities; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Series; Tennessee; Training; Translational Research; Underrepresented Minority; United States; Universities; anticancer research; cancer clinical trial; cancer health disparity; cancer initiation; career; collaborative approach; community based participatory research; community organizations; education research; evidence base; graduate student; health care disparity; high school; improved; malignant breast neoplasm; medical schools; minority communities; mortality; multidisciplinary; outcome disparities; outreach; outreach program; programs; recruit; screening; socioeconomics; survivorship; treatment trial; undergraduate student; underserved community

PROJECT SUMMARY: OVERALL Cancer health disparities based on factors such as race and ethnicity are the result of a combination of socioeconomic, environmental, behavioral, and biological factors. These disparities impact cancer incidence, prevalence, mortality, survivorship, financial burden, and screening rates. The long-standing and mature Meharry Medical College (MMC), Vanderbilt-Ingram Cancer Center (VICC), Tennessee State University (TSU) Cancer Partnership (MVTCP), continues to provide and expand upon an exceptional cancer research and training environment to support the efforts of diverse investigators in addressing disparities. These efforts span across multiple disciplines to study the determinants of cancer health disparities at an NCI-designated comprehensive cancer center (VICC) along with enhancing research infrastructure, capacity-building, and impact at two minority- serving institutions (MMC and TSU). Collectively, over the past twenty years of partnership, these collaborative efforts provide a robust infrastructure to address and overcome cancer disparities while expanding research opportunities, recruitment and training. Our Triad has benefited from sustained and strong collaborative interactions between the three partner institutions, resulting in robust community and educational outcomes. Moreover, the geographical placement of this Triad in Tennessee, a region with some of the highest cancer incidence and mortality rates in the United States, also provides a unique opportunity for our Partnership to positively impact outcomes for cancer patients in this geographical region. This region continues to have significant cancer health disparities in lung, breast, prostate, and colorectal cancers. In order to meet our ultimate goals of overcoming cancer disparities while simultaneously strengthening research impact, the overall objectives of this competing renewal application are to: 1) increase the participation in traditional, investigator- initiated cancer research projects awarded to MMC and TSU faculty with collaborative guidance by senior VICC faculty; 2) increase the number of investigator-initiated awards to VICC junior faculty that address cancer disparities; 3) recruit, train and retain early-stage investigators to become independent leaders in cancer health disparities and cancer research and training; 4) expand MVTCP participation in national oncology treatment and interventional trials; 5) strengthen the physical and intellectual infrastructure for research at MMC and TSU; 6) facilitate partnerships between community organizations and academic researchers, leading to hypothesis- driven research projects that include the involvement of a community health educator; 7) increase the number of MMC and TSU trainees engaged in cancer research; and 8) increase awareness of cancer research opportunities and careers for minority high school, undergraduate, graduate and medical students through the Pathway to Discovery program.

项目摘要：总体 基于种族和种族等因素的癌症健康差异是结合的结果 社会经济，环境，行为和生物学因素。这些差异会影响癌症的发病率， 患病率，死亡率，生存，经济负担和筛查率。长期而成熟的梅哈里 田纳西州立大学（TSU）癌症的范德比尔特 - 伊格兰癌症中心（VICC）医学院（MMC） 合作伙伴关系（MVTCP）继续在卓越的癌症研究和培训上提供和扩展 环境支持各种研究者在解决差异方面的努力。这些努力跨越 多个学科研究NCI指定的综合性癌症健康差异的决定因素 癌症中心（VICC）以及增强研究基础设施，能力建设以及对两个少数族裔的影响 服务机构（MMC和TSU）。在过去的二十年的合作伙伴关系中，这些合作伙伴关系共同 努力提供了强大的基础设施来解决和克服癌症差异，同时扩大研究 机会，招聘和培训。我们的三合会受益于持续和强大的合作 这三个合作伙伴机构之间的互动，从而带来了强大的社区和教育成果。 此外，该三合会在田纳西州的地理位置，一个癌症最高的地区 美国的发病率和死亡率也为我们的伙伴关系提供了独特的机会 对该地理区域的癌症患者的结果产生积极影响。这个地区继续 肺，乳房，前列腺和结直肠癌的明显癌症健康差异。为了满足我们的最终 克服癌症差异同时加强研究影响的目标，总体 此类竞争续签应用的目标是：1）增加参与传统，调查员的参与 - 由高级VICC的合作指导授予MMC和TSU教师的发起癌症研究项目 学院; 2）增加调查员颁发的奖项的数量 差异； 3）招募，培训和留住早期研究人员成为癌症健康的独立领导者 差异和癌症研究和培训； 4）扩大MVTCP参与国家肿瘤治疗和 介入试验； 5）加强在MMC和TSU研究的物理和智力基础设施； 6） 促进社区组织与学术研究人员之间的伙伴关系，导致假设 - 驱动的研究项目，包括社区健康教育者的参与； 7）增加数字 从事癌症研究的MMC和TSU学员的； 8）提高对癌症研究的认识 通过少数民族高中，本科，研究生和医学生的机会和职业 发现计划的途径。

项目成果

Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis.

• DOI: 10.18632/aging.101213
• 发表时间: 2017-03-26
• 期刊: Aging
• 作者: Uzhachenko R;Boyd K;Olivares-Villagomez D;Zhu Y;Goodwin JS;Rana T;Shanker A;Tan WJ;Bondar T;Medzhitov R;Ivanova AV
• 通讯作者: Ivanova AV

Doctoral degrees open new career doors.

博士学位打开了新的职业大门。

• 发表时间: 2011
• 期刊: ONS connect
• 作者: Wujcik,DebraM

Pouch-related dysplasia and adenocarcinoma following restorative proctocolectomy for ulcerative colitis.

• DOI: 10.1007/s10151-010-0664-2
• 发表时间: 2011-03
• 期刊: TECHNIQUES IN COLOPROCTOLOGY
• 影响因子: 3.3
• 作者: Um, J. W.;M'Koma, A. E.
• 通讯作者: M'Koma, A. E.

A randomized trial comparing the effect of two phone-based interventions on colorectal cancer screening adherence.

• DOI: 10.1007/s12160-011-9291-z
• 发表时间: 2011-12
• 期刊: ANNALS OF BEHAVIORAL MEDICINE
• 影响因子: 3.8
• 作者: Menon, Usha;Belue, Rhonda;Wahab, Stephanie;Rugen, Kathryn;Kinney, Anita Y.;Maramaldi, Peter;Wujcik, Debra;Szalacha, Laura A.
• 通讯作者: Szalacha, Laura A.

Tributyltin alters secretion of interleukin 1 beta from human immune cells.

• DOI: 10.1002/jat.3087
• 发表时间: 2015-08
• 期刊: JOURNAL OF APPLIED TOXICOLOGY
• 影响因子: 3.3
• 作者: Brown, Shyretha;Whalen, Margaret
• 通讯作者: Whalen, Margaret