Clinical Relevance of Mismatch Repair in Ovarian Cancer

卵巢癌错配修复的临床意义

• 批准号: 7496110
• 负责人: Tuya Pal
• 金额: $ 13.28万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7496110
• 关键词: Achievement; Address; Age; Area; Cancer Center; Cancer Patient; Cessation of life; Characteristics; Clinical; Colorectal Cancer; Commit; Communities; Complex; Data; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Epigenetic Process; Epithelial ovarian cancer; Etiology; Faculty; Family Cancer History; Family history of; Functional disorder; Gene Mutation; Genes; Genetic; Genetic Research; Germ-Line Mutation; Goals; Health Sciences; Hereditary Nonpolyposis Colorectal Neoplasms; Histology; Hormonal Risk Factor; Hypermethylation; Incidence; Inherited; Institution; Investigation; Knowledge; Laboratories; Laboratory Markers; Learning; MLH1 gene; MSH2 gene; MSH6 gene; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Mayo Clinic Cancer Center; Medical Records; Mentors; Mentorship; Methodology; Methylation; Microsatellite Instability; Microsatellite Repeats; Mismatch Repair; Modeling; Molecular; Molecular Genetics; Mutation; Mutation Analysis; Nature; Ovarian; Pathogenesis; Pathway interactions; Patients; Postdoctoral Fellow; Predictive Factor; Predisposition; Prevalence; Prognostic Marker; Proteins; Questionnaires; Rate; Research; Research Design; Research Methodology; Research Personnel; Research Training; Resources; Risk Factors; Role; Sampling; Scientist; Stage at Diagnosis; Standards of Weights and Measures; Syndrome; Testing; Therapeutic; Training; Translating; Translational Research; Tumor Biology; United States; Woman; Work; base; cancer genetics; career; clinically relevant; design; experience; follow-up; genetic epidemiology; improved; interdisciplinary approach; mortality; outcome forecast; ovarian neoplasm; prognostic; programs; promoter; protein expression; research study; response; skills; statistics; tool; translational study; tumor; tumorigenesis

A 5-year program integrating research, education, and teaching will provide the applicant with an excellent opportunity for the acquisition and refinement of skills in research methods that include design, conduct and analysis of high-quality epidemiologically-based cancer genetics research, under expert guidance of scientists in the field. Specific areas of focus for didactic training will be: 1) genetic epidemiology, 2) study design and statistical methodology, 3) laboratory-based molecular analyses, and 4) ovarian tumor biology, with the goal of applying this knowledge in translational research. The training and research objectives will be accomplished through formal training (course work), mentorship (through mentors/consultants who are experts in genetic epidemiology, statistics, molecular genetics and ovarian tumorigenesis), and practical experience (through conducting proposed research study). This particular project will address all learning objectives of the applicant through the various components of molecular, pathological and statistical analyses, and will provide her with the practical experience in these specific areas outlined. Through the provision of meaningful scientific data, the project itself will augment existing research associated with the genetics of ovarian cancer susceptibility with laboratory markers. It will build upon current knowledge in deciphering etiology and predicting prognosis and treatment response as it relates to the mismatch repair pathway to ovarian tumorigenesis, and form the basis of further translational studies. Dr. Pal's long-term goal is to develop a program of research in epidemiologically-based cancer genetics research utilizing an interdisciplinary approach. This goal will be accomplished by being in a faculty role at an academic health science center. The resources of the sponsoring institution are excellent and will facilitate the successful, efficient completion of the overall objectives outlined. The achievement of these goals will provide the expertise needed for a career as a successful, independent investigator committed to academic research.

整合研究，教育和教学的5年计划将为申请人提供出色的 在包括设计，行为和 在专家指导下的高质量基于流行病学的癌症遗传学研究的分析 该领域的科学家。教学训练的特定重点领域将是：1）遗传流行病学，2）研究 设计和统计方法论，3）基于实验室的分子分析和4）卵巢肿瘤生物学， 目的是将这些知识应用于翻译研究。培训和研究目标将 可以通过正规培训（课程工作），指导来完成（通过 遗传流行病学，统计学，分子遗传学和卵巢肿瘤发生的专家和实用 经验（通过进行拟议的研究）。这个特定的项目将解决所有学习 申请人通过分子，病理和统计的各个组成部分的目标 分析，并将在这些特定领域提供实际经验。通过 提供有意义的科学数据，该项目本身将扩大与 卵巢癌易感性具有实验室标记的遗传学。它将基于当前的知识 解密病因并预测与不匹配修复有关的预后和治疗反应 通往卵巢肿瘤发生的途径，并构成了进一步翻译研究的基础。 Pal博士的长期 目标是制定基于流行病学的癌症遗传学研究计划 跨学科方法。这个目标将通过担任学术健康的教师角色来实现 科学中心。赞助机构的资源非常出色，将有助于成功， 有效完成概述的总体目标。这些目标的实现将为 作为一名成功的独立研究者，职业所需的专业知识致力于学术研究。