Clinical Relevance of Mismatch Repair in Ovarian Cancer

卵巢癌错配修复的临床意义

• 批准号: 7033262
• 负责人: Tuya Pal
• 金额: $ 13.27万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7033262
• 关键词: clinical research; gene mutation; neoplasm /cancer; ovary neoplasms

DESCRIPTION (provided by applicant): A 5-year program integrating research, education, and teaching will provide the applicant with an excellent opportunity for the acquisition and refinement of skills in research methods that include design, conduct and analysis of high-quality epidemiologically-based cancer genetics research, under expert guidance of scientists in the field. Specific areas of focus for didactic training will be: 1) genetic epidemiology, 2) study design and statistical methodology, 3) laboratory-based molecular analyses, and 4) ovarian tumor biology, with the goal of applying this knowledge in translational research. The training and research objectives will be accomplished through formal training (course work), mentorship (through mentors/consultants who are experts in genetic epidemiology, statistics, molecular genetics and ovarian tumorigenesis), and practical experience (through conducting proposed research study). This particular project will address all learning objectives of the applicant through the various components of molecular, pathological and statistical analyses, and will provide her with the practical experience in these specific areas outlined. Through the provision of meaningful scientific data, the project itself will augment existing research associated with the genetics of ovarian cancer susceptibility with laboratory markers. It will build upon current knowledge in deciphering etiology and predicting prognosis and treatment response as it relates to the mismatch repair pathway to ovarian tumorigenesis, and form the basis of further translational studies. Dr. Pal's long-term goal is to develop a program of research in epidemiologically-based cancer genetics research utilizing an interdisciplinary approach. This goal will be accomplished by being in a faculty role at an academic health science center. The resources of the sponsoring institution are excellent and will facilitate the successful, efficient completion of the overall objectives outlined. The achievement of these goals will provide the expertise needed for a career as a successful, independent investigator committed to academic research.

描述（由申请人提供）：一项为期5年的计划，整合研究，教育和教学，将为申请人提供一个很好的机会，以在研究方法中获得和完善技能，包括在该领域的科学家专家指南下，包括设计，行为和基于流行病学的癌症遗传学研究的设计，行为和分析。教学训练的特定重点领域将是：1）遗传流行病学，2）研究设计和统计方法论，3）基于实验室的分子分析和4）卵巢肿瘤生物学，目的是将这种知识应用于转化研究。培训和研究目标将通过正式培训（课程工作），指导（通过是遗传流行病学，统计学，分子遗传学和卵巢肿瘤的专家）以及实践经验（通过进行拟议的研究）来实现的。这个特定的项目将通过分子，病理和统计分析的各个组成部分来解决申请人的所有学习目标，并将在这些特定领域提供实际经验。通过提供有意义的科学数据，该项目本身将扩大与实验室标记卵巢癌易感性易感性相关的现有研究。它将基于当前的解密病因学知识，并预测与卵巢肿瘤发生的不匹配修复途径有关的预后和治疗反应，并构成了进一步转化研究的基础。 PAL博士的长期目标是通过跨学科方法制定基于流行病学的癌症遗传学研究计划。这个目标将通过在学术健康科学中心担任教师角色来实现。赞助机构的资源非常出色，将有助于成功，有效地完成概述的整体目标。实现这些目标将为成功的独立研究人员提供职业所需的专业知识，从而致力于学术研究。