Cadiorenal and Metabolic Diseases Research Center

心肾和代谢疾病研究中心

基本信息

批准号：
9070043
负责人：
John E Hall
金额：
$ 228.53万
依托单位：
UNIVERSITY OF MISSISSIPPI MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-05 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9070043
关键词：
Area Basic Science Biochemistry Bioinformatics Biomedical Research Cardiology Cardiovascular Diseases Centers of Research Excellence Cessation of life Clinical Clinical Research Collaborations Complex Core Facility Coronary Arteriosclerosis Development Diabetes Mellitus Discipline Disease Education Emerging Technologies Endocrinology Environment Equipment Faculty Fostering Funding Genetic Goals High Prevalence Housing Hypertension Institution Interdisciplinary Study Investments Kidney Diseases Link Medical Students Medical center Mentors Metabolic Diseases Minority-Serving Institution Mississippi Molecular Biology Molecular Genetics Morbidity - disease rate Nephrology Neurosciences Obesity Pathology Pharmacology Physiology Population Population Research Postdoctoral Fellow Recruitment Activity Renal function Research Research Infrastructure Research Personnel Research Project Grants Research Support Risk Factors Scientist Services Stroke Systems Analysis Training Training Programs Translational Research Translations Underrepresented Minority United States United States National Institutes of Health Universities Work career development graduate student improved in vivo imaging innovation minority investigator mortality multidisciplinary next generation novel therapeutic intervention pre-doctoral prevent programs public health relevance research and development research facility

项目摘要

DESCRIPTION (provided by applicant): Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. These disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of cardiovascular and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for cardiovascular diseases such coronary artery disease and stroke. Understanding the complex relationships among cardiovascular, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this proposal is to develop an internationally recognized Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims are: 1) To develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of junior investigators for independent funding from NIH and other national biomedical research programs.; 2) To develop mentoring and education programs and research support for promising junior investigators so that they can become productive, independent investigators who can successfully compete for NIH funding; 3) To achieve the specific aims of the research projects described by the junior investigators in this proposal, and to foster their career development; 4) To develop a pipeline of diverse predoctoral graduate students, medical students and postdoctoral fellows trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis will be placed on recruiting and mentoring underrepresented minority investigators through partnerships with local minority institutions; 5) To enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, as well as with external partners; 6) To strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research and in emerging technologies, such as in vivo imaging, molecular genetics, bioinformatics, and systems analysis.

描述（由申请人提供）：心血管，肾脏和代谢疾病是密不可分的，是美国死亡率和发病率的主要原因，尤其是在密西西比州，在这些疾病中的患病率最高。这些疾病通常聚集在一起，并且高度相互依存。肥胖和相关的代谢疾病（例如糖尿病）是心血管和肾脏疾病的主要原因。肾脏功能异常是高血压的重要原因，也是心血管疾病等冠状动脉疾病和中风的关键危险因素。了解心血管，肾脏和代谢疾病之间的复杂关系并开发新的治疗方法需要研究范式的范式转变，并结合了基本，临床和人群科学家的努力，并结合了多学科综合方法。该提案的一个主要目的是开发一个国际认可的心脏和代谢性疾病研究中心（CMDRC），该疾病汇集了一个多学科的基本，临床和人群科学家，致力于共同的协同主题，并促进他们的合作。具体目的是：1）开发促进基础设施和核心设施在心脏和代谢疾病方面的基本，临床和人群研究方面的卓越表现，并提高了NIH和其他国家生物医学研究计划的初级研究人员的竞争力。 2）为有前途的初级调查人员开发指导和教育计划和研究支持，以便他们可以成为可以成功竞争NIH资金的富有成效的独立研究人员； 3）实现初级研究人员在本提案中描述的研究项目的具体目标，并促进其职业发展； 4）开发了一条多种多样的研究生，医学生和在尖端心脏和代谢疾病研究的培训的博士后研究员的管道，以便他们成为该领域的下一代研究人员；主要重点将通过与当地少数族裔机构的合作伙伴关系来招募和指导代表性不足的少数群体调查员； 5）增强来自UMMC的心脏和代谢疾病多个学科的既定研究人员之间的合作和互动，以及与外部伴侣的合作； 6）通过招募具有临床和转化研究和新兴技术方面的专业知识的新教师（例如在体内成像，分子遗传学，生物信息学和系统分析）中，可以加强UMMC的心脏和代谢疾病研究。