2023 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

2023肌肉：兴奋-收缩耦合戈登研究会议暨戈登研究研讨会

• 批准号: 10606049
• 负责人: Francisco J Alvarado
• 金额: $ 3.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10606049
• 关键词: Address; American; Area; Arrhythmia; Awareness; Basic Science; Biophysics; COVID-19; Calcium; Cardiac; Clinical; Clinical Research; Communication; Communities; Consultations; Coupled; Coupling; Dedications; Development; Diabetes Mellitus; Discipline; Disease; Elements; Environment; Europe; Faculty; Female; Fostering; France; Functional disorder; Gender; Geographic Locations; Goals; Growth; Health; Heart; Heart failure; Homeostasis; Human; Individual; Institution; International; Ions; Italy; Knowledge; Leadership; Malignant hyperpyrexia due to anesthesia; Medical; Memory; Metabolism; Molecular; Muscle; Muscle Fatigue; Muscle function; Muscular Dystrophies; Myocardium; New Hampshire; New Zealand; Nuclear; Organelles; Participant; Pathologic; Persons; Pharmacology; Physiological; Physiology; Postdoctoral Fellow; Productivity; Protein Biochemistry; Proteins; Quality of life; Race; Relaxation; Research; Research Personnel; Role; Ryanodine Receptor Calcium Release Channel; Science; Scientist; Signal Transduction; Skeletal Muscle; Smooth Muscle; Stretching; Striated Muscles; Structure; Students; Therapeutic; Translational Research; Translations; Underrepresented Minority; Work; career; career development; college; comparative; innovation; insight; meetings; nano; nanoscale; notch protein; novel; novel therapeutic intervention; posters; professor; programs; receptor; skeletal; structural biology; success; symposium; translational medicine

ABSTRACT This proposal seeks partial support for the Gordon Research Conference (GRC) on Muscle Excitation- Contraction coupling (ECC). This is the only major national/international meeting on this important topic. For cardiac, skeletal and smooth muscle we will delve into normal physiological function, dysfunction in disease and potential therapeutics at levels from molecular biophysics, electrical and calcium-dependent signaling to integrated function. This GRC will meet June 4-9, 2023 at Colby-Sawyer College in New Hampshire. The program was developed in consultation with a broad advisory group of leaders in ECC research. This Group and the GRC are chaired by Drs. Donald M Bers (USA) and Ana Gómez (France). Support is also sought for an associated Gordon Research Seminar (GRS) that is led by and focused upon early stage investigators (ESIs; students, postdocs and new faculty). This GRS immediately precedes the GRC and is chaired by two ESIs (Michelle Munro in New Zealand, and Francisco Alvarado in the USA). The two overarching objectives of the GRC and GRS are to: 1) Assemble top-notch scientist-speakers and participants to share new breakthroughs, stimulate and participate in deep and broad discussions that span from molecular mechanisms to integrated physiology and pathophysiology in cardiac, skeletal and smooth muscle, and 2) Increase the visibility and leadership of junior ECC ESIs and inspire/motivate their research careers by providing an interactive informal forum in which to present their work and network. The 2023 ECC GRC will have ~37 speakers, ~6 shorter talks to highlight selected poster abstracts and ~18 topic discussion leaders. Scientific sessions will detail the structure-function of ECC at multiple scales ranging, from molecular level to the translation into new therapeutic strategies for ECC-related. Sessions include, 1) L-type Ca Channels, 2) Ryanodine Receptors, 3) IP3 Receptors and Nuclear Signaling, 4) Malignant Hyperthermia and CPVT-Arrhythmias, 5) Store-Operated Ca entry, TRP and stretch-activated channels, 6) Muscular Dystrophy and Diabetes, and 8) Heart Failure and Skeletal Muscle Fatigue. Cardiac, skeletal and smooth muscle will be discussed together to highlight similarities and differences to enhance understanding of each muscle type at molecular and muscle levels in health and disease. The GRS will help ESIs develop self-confidence and sense of community that will encourage their full engagement in formal and informal discussion with senior colleagues during the GRC. The GRC will highlight ESI presentations in several ways (short talks, Poster Flash talks and discussion co-leaders) that heighten the exposure of these junior investigators and their novel research. We expect to attract ~175 basic and clinical researchers across career stages, genders, races, heritages, research disciplines, institutions, and geographical locations. We aim to promote: 1) open dialogue and communication, 2) visibility and career development for ESIs, 3) substantial new and deep knowledge about how muscle functions normally, what goes wrong in disease and what novel therapeutic strategies may benefit those afflicted by numerous diseases.

抽象的 该提案寻求对戈登研究会议（GRC）的部分支持 - 收缩耦合（ECC）。这是有关此重要主题的唯一主要国家/国际会议。为了 心脏，骨骼和平滑肌我们将深入探究正常的生理功能，疾病功能障碍和 从分子生物物理学，电和钙依赖性信号转导至 集成功能。该GRC将于2023年6月4日至9日在新罕布什尔州的Colby-Sawyer学院开会。这 与ECC研究领导者的广泛咨询小组协商开发了计划。这个小组和 GRC由Drs主持。唐纳德·M·贝尔斯（Donald M Bers）（美国）和安娜·戈梅斯（AnaGómez）（法国）。也寻求支持 相关的戈登研究研讨会（GRS）由早期研究人员（ESIS; 学生，博士后和新教师）。这紧接在GRC之前，由两个ESI主持 （新西兰的Michelle Munro和美国的Francisco Alvarado）。两个总体对象 GRC和GRS将要：1）组装一流的科学家和参与者，分享新的突破， 刺激并参与从分子机制到综合的深度和广泛讨论 心脏，骨骼和平滑肌的生理学和病理生理学，以及2）增加可见度和 初级ECC ESI的领导，并通过提供互动式非正式来激发/激发他们的研究职业 介绍他们的工作和网络的论坛。 2023 ECC GRC将有〜37位扬声器，〜6个较短的谈话 强调选定的海报摘要和〜18主题讨论负责人。科学会议将详细介绍 ECC在多个尺度上的结构功能，从分子水平到转化为新疗法 与ECC相关的策略。会话包括1）L型CA通道，2）Ryanodine受体，3）IP3受体 和核信号传导，4）恶性高温和CPVT - 心律不齐，5）商店经营的CA进入，TRP 和拉伸激活的通道，6）肌肉营养不良和糖尿病，以及8）心力衰竭和骨骼肌肉 疲劳。心脏，骨骼和平滑肌将一起讨论，以突出相似性和差异 在健康和疾病中，以分子和肌肉水平上的每种肌肉类型的理解。 GRS 将帮助ESI发展自信心和社区意识，这将鼓励他们全面参与 GRC期间与高级同事的正式和非正式讨论。 GRC将重点介绍ESI演示 通过几种方式（简短的谈话，海报闪光谈话和讨论共同领导者），增强了这些暴露 初级研究人员及其新研究。我们希望吸引〜175个基本和临床研究人员 职业阶段，性别，种族，遗产，研究学科，机构和地理位置。我们的目标 促进：1）公开对话和沟​​通，2）ESI的可见性和职业发展，3）实质性 关于肌肉正常功能，疾病中出了什么问题以及什么新颖的新知识 治疗策略可能会使众多疾病折磨的人受益。