Cardiorenal and Metabolic Diseases Research Center

心肾与代谢疾病研究中心

• 批准号: 10630577
• 负责人: John E Hall
• 金额: $ 116.25万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630577
• 关键词: Acceleration; Area; Basic Science; Biomedical Research; Book Chapters; Books; Cardiorenal syndrome; Cardiovascular Diseases; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Collaborations; Complex; Core Facility; Coronary Arteriosclerosis; Dedications; Development; Diabetes Mellitus; Discipline; Disease; Education; Ensure; Equipment; Extramural Activities; Faculty; Fostering; Funding; Grant; Healthcare Systems; High Prevalence; Hypertension; Infrastructure; Institution; Interdisciplinary Study; International; Kidney Diseases; Laboratory Research; Link; Mentors; Metabolic Diseases; Mississippi; Morbidity - disease rate; Obesity; Paper; Phase; Pilot Projects; Population; Population Research; Postdoctoral Fellow; Productivity; Publishing; Renal function; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Services; Stroke; Training; Training Programs; Translational Research; Translations; Underrepresented Minority; United States; United States National Institutes of Health; Work; cardiovascular risk factor; clinical center; disability; improved; innovation; kidney dysfunction; minority investigator; mortality; multidisciplinary; next generation; novel therapeutic intervention; prevent; programs; recruit; research and development; student training; success

OVERALL PROJECT SUMMARY/ABSTRACT Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes mellitus, are major causes of CV and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for CV diseases such as coronary artery disease and stroke. Understanding the complex relationships among CV, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this Phase 3 COBRE proposal is to amplify the success of Phases 1 and 2 in developing a leading Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims for Phase 3 are: 1) To further develop CMDRC infrastructure, a well-organized highly productive Pilot Projects Program (PPP), and sustainable research core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increased competitiveness of CMDRC investigators for independent funding from NIH and other national biomedical research programs; 2) To enhance CMDRC mentoring and education programs that provide support for PPP investigators as well as other promising researchers so that they can become productive, independent investigators who are also effective collaborators on multidisciplinary research teams; 3) To amplify our pipeline of diverse postdoctoral fellows and students trained in cutting-edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis is placed on recruiting and mentoring underrepresented minority investigators through partnerships with local institutions and by leveraging training programs at UMMC; 4) To enhance collaborations and interactions among established and junior investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, other IDeA supported programs, and external partners. These interactions will leverage resources provided by UMMC and other IDeA programs; 5) To further expand the number of highly productive, extramurally funded cardiorenal and metabolic disease researchers at UMMC by leveraging institutional resources to recruit additional new faculty with expertise in clinical and translational research, and in areas where there are gaps in CMDCR expertise. The CMDRC has been a major driver for marked expansion of cardiorenal and metabolic diseases research in Mississippi. Phase 3 support will amplify and ensure sustainability of our efforts to develop a highly productive CMDRC dedicated to improving lives through research, discovery, and innovation.

全面的 项目摘要/摘要 心血管（CV），肾脏和代谢疾病密不可分，是死亡的主要原因 和美国的发病率，尤其是在密西西比州 疾病。心脏和代谢性疾病通常聚集在一起，并且高度相互依存。肥胖 相关的代谢疾病（例如糖尿病）是简历和肾脏疾病的主要原因。 异常肾功能是高血压的重要原因，也是高血压的结果，这是一个关键的风险因素 简历疾病，例如冠状动脉疾病和中风。了解简历之间的复杂关系， 肾脏和代谢疾病以及开发新的治疗方法需要研究范式转变 结合了基本，临床和人群的努力，结合了多学科综合方法 科学家。该阶段3毛线建议的主要目的是扩大第1阶段和2的成功 开发主要的心脏和代谢疾病研究中心（CMDRC），该研究中心汇集了 多学科的基本，临床和人群科学家的多学科小组，致力于共同的协同主题， 促进他们的合作。第3阶段的具体目的是：1）进一步发展CMDRC基础架构， 组织良好的高产试点项目计划（PPP）以及可持续的研究核心设施 促进心脏和代谢疾病的基本，临床和人口研究卓越，并增加 CMDRC调查人员在NIH和其他国家生物医学的独立资金中的竞争力 研究计划； 2）增强CMDRC指导和教育计划，为PPP提供支持 研究人员以及其他有前途的研究人员，以便他们可以变得富有成效，独立 也是多学科研究团队有效合作者的研究人员； 3）放大我们的管道 多样的博士后研究员和接受过尖端心脏和代谢疾病研究的学生 因此，他们成为该领域的下一代研究人员。重点放在招聘和 通过与当地机构的伙伴关系和利用，指导代表性不足的少数群体调查员 UMMC的培训计划； 4）增强建立和初级的合作和互动 来自UMMC的心脏和代谢疾病多个学科的研究者，其他想法支持 程序和外部合作伙伴。这些互动将利用UMC和其他想法提供的资源 程序； 5）进一步扩大高产，外部资助的心脏和代谢的数量 UMMC的疾病研究人员利用机构资源来招募其他新教师 临床和转化研究以及CMDCR专业知识差距的领域方面的专业知识。这 CMDRC一直是明显扩展心脏和代谢性疾病研究的主要驱动力 密西西比州。第三阶段的支持将放大并确保我们努力发展高产能力的可持续性 CMDRC致力于通过研究，发现和创新来改善生活。