Methods in Clinical Cancer Research Workshop

临床癌症研究方法研讨会

• 批准号: 10721362
• 负责人: MANUEL HIDALGO
• 金额: $ 7万
• 依托单位: AMERICAN ASSOCIATION FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10721362
• 关键词: Acceleration; Address; American Association of Cancer Research; American Society of Clinical Oncology; Area; Basic Science; Cancer Patient; Career Choice; Caring; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Conduct Clinical Trials; Consent Forms; Contracts; Data; Data Reporting; Development; Discipline; Educational workshop; Effectiveness; Ensure; Ethnic Origin; Evaluation; Faculty; Feedback; Fostering; Funding; Future; Gender; Geography; Goals; Grant; Home; Immunologics; Individual; Institution; Institutional Review Boards; International; Knowledge; Malignant Neoplasms; Mentors; Mentorship; Methodology; Methods; National Cancer Institute; New Agents; Oncology; Participant; Patient Recruitments; Patient Self-Report; Patients; Phase; Positioning Attribute; Prevention; Preventive; Procedures; Process; Program Effectiveness; Protocols documentation; Public Health; Publications; Published Comment; Research Personnel; Review Literature; Site; Speed; Student Selections; Students; Surveys; Teaching Method; Technology; Testing; Training; Translational Research; Work; anticancer research; cancer clinical trial; cancer therapy; career; career development; career networking; clinical practice; clinical trial readiness; data mining; design; effectiveness evaluation; evaluation/testing; experience; falls; flexibility; follow-up; improved; lectures; member; novel therapeutics; patient oriented research; peer; phase 2 designs; phase II trial; pre-clinical; prevent; programs; protocol development; recruit; sound; student participation; success; targeted treatment; tool; trial design

Project Summary/Abstract The Methods in Clinical Cancer Research Workshop is a week-long program designed to educate and train early-career investigators in the best practices of clinical trial design, provide access to experienced clinical investigators from different institutions with expertise across all areas of clinical research, and develop and foster both peer-to-peer and mentoring relationships to enhance career development beyond the dates of the Workshop. Students are selected using a competitive application process that consists of a protocol concept, personal statement, and support from an existing mentor. Those accepted to the Workshop will have access to dozens of faculty members who, through the course of the Workshop, will help students develop concept sheets into IRB-ready clinical trials, including informed consent documents, ready for submission at their home institutions. Students participate in pre- and post-tests to determine the effectiveness of the program, which features a mix of didactic lectures, small group discussions, one-on-one mentoring sessions, and daily protocol development group sessions. The protocol development group sessions are made up of 3-4 faculty members and 8-10 students that work collaboratively as a group for the week. This makes up the core of the Workshop as the groups meet daily to review progress made each day and provide feedback and guidance for next steps in their individual trial designs. Daily, progressive assignments are submitted each evening, with reviews and comments from the faculty provided the following morning. The Workshop is offered to early-career investigators in all oncology disciplines who are nearing completion of their training or have recently begun their initial faculty positions. A review of the literature, comments from Workshop attendees, and the number of similar programs being developed in the U.S. and internationally shows that, despite advances in basic science and new preclinical agent development, there is a serious shortage of clinical investigators who have the pre-requisite knowledge to actually design and conduct effective clinical trials to match the attributes of these new agents. With the ever-increasing pace of technology and its implications in clinical trial design, the knowledge and number of tools that a clinical investigator needs to be able to utilize effectively continue to grow at a rapid rate. The Workshop is designed to address the needs today, while maintaining flexibility to implement changes to train early-career investigators on how to conduct effective clinical trials in the future. The Workshop is organized by the American Association for Cancer Research and the American Society of Clinical Oncology and has provided training to over 1800 investigators since its’ inception in 1996. The Workshop is evaluated through the use of pre- and post-tests given to the students; daily and week-long evaluations completed onsite; a 1-year, 3-year, 5-year, and 10-year followup survey each fall. The Workshop also contracted with an independent data-mining and analysis firm in 2013-2014 to provide a long-term historical comparison of students and non-students (applicants that were not accepted) that quantified their effectiveness pre- and post-Workshop in the areas of successful clinical trials, publications, grants, and collaborations.

项目摘要/摘要 临床癌症研究研讨会的方法是一个为期一周的计划 教育和培训早期职业调查人员临床试验设计的最佳实践，提供 从不同机构的经验丰富的临床调查人员访问所有人的专家 临床研究的领域以及发展和培养对等关系和心理关系 为了增强职业发展，超出了研讨会的日期。选择学生使用 由协议概念，个人陈述和 现有心理的支持。那些接受研讨会的人将可以访问数十个 在研讨会过程中，教师将帮助学生发展概念 表片进入IRB就绪的临床试验，包括知情同意文件，可以准备 在其家庭机构提交。 学生参加预测试和后测试，以确定该计划的有效性， 具有教学演讲，小组讨论，一对一的心理课程的混合 和日常协议开发小组会议。协议开发小组会议是 由3-4名教职员工和8-10名学生组成，他们作为小组合作工作 星期。当小组每天开会以审查进度时，这构成了研讨会的核心 每天都在他们的个人审判中为下一步提供反馈和指导 设计。每天，每天晚上都会提交进步任务，并进行评论和 第二天早上提供了教师的评论。 该研讨会提供给所有即将接近的肿瘤学学科的早期研究人员 完成他们的培训或最近开始他们的最初教师职位。评论 文学，研讨会参与者的评论以及类似计划的数量 在美国和国际上开发 新的临床前代理开发，严重缺乏临床研究人员 实际设计和进行有效的临床试验以匹配的先决条件知识 这些新代理的属性。随着技术的不断增长及其含义 在临床试验设计中，临床研究者需要的知识和数量需要 可以有效利用以快速的速度继续增长。该研讨会旨在解决 今天的需求，同时保持灵活性以实施更改以培训早期职业者 研究人员将来如何进行有效的临床试验。研讨会是组织的 美国癌症研究协会和美国临床学会 自1996年成立以来，肿瘤学并已为1800多名调查人员提供了培训。 通过使用给学生的预测试和后测试来评估研讨会；日常的 为期一周的评估完成了现场； 1年，3年，5年和10年的随访 每年秋天的调查。研讨会还与独立的数据挖掘和分析签约 2013 - 2014年的公司提供了对学生和非学生的长期历史比较 （未接受的申请人）量化了其有效性前和工作后的效力 成功的临床试验，出版物，赠款和合作的领域。

项目成果

A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop.

• DOI: 10.1158/1078-0432.ccr-21-1799
• 发表时间: 2021-10-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Von Hoff DD;Clark GM;Coltman CA;Disis ML;Eckhardt SG;Ellis LM;Foti M;Garrett-Mayer E;Gönen M;Hidalgo M;Hilsenbeck SG;Littlefield JH;LoRusso PM;Lyerly HK;Meropol NJ;Patel JD;Piantadosi S;Post DA;Regan MM;Shyr Y;Tempero MA;Tepper JE;Von Roenn J;Weiner LM;Young DC;Vu NV
• 通讯作者: Vu NV

Comparison of young clinical investigators' accuracy and reproducibility when measuring pulmonary and skin surface nodules using a circumferential measurement versus a standard caliper measurement: American Association for Cancer Research/American Society

年轻临床研究人员使用圆周测量与标准卡尺测量测量肺部和皮肤表面结节时的准确性和再现性的比较：美国癌症研究协会/美国协会

• DOI: 10.1200/jco.2000.18.2.437
• 发表时间: 2000
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Monsky,WL;Heddens,DK;Clark,GM;VonHoff,DD;ColtmanJr,CA;Dorr,RT;Alberts,DS
• 通讯作者: Alberts,DS