System for Measuring Tissue Oxygenation

组织氧合测量系统

基本信息

批准号：
8882628
负责人：
Gregory John Seifert
金额：
$ 15万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2016-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8882628
关键词：
Active Sites Affect Anesthesia procedures Biochemistry Biophysics Blood flow Caliber Calibration Clinic Clinical Collaborations Coupled Dendrimers Devices Doctor of Medicine Doctor of Philosophy Electron Transport Electronics Energy Metabolism Energy Transfer Engineering Ensure Erythrocyte Transfusion Erythrocytes Evaluation Fluorescence Funding Generations Hemorrhagic Shock Hour Image In Vitro Laboratories Length Marketing Measurement Measures Medical Medical Device Medical Electronics Medicine Metabolism Methods Microscopy Miniaturization Monitor Needles Optics Organ failure Organic Chemistry Oxygen Pathway interactions Patients Pediatrics Pennsylvania Performance Peripheral Peripheral Vascular Diseases Phase Physiological Polyethylene Glycols Positioning Attribute Principal Investigator Property Reaction Time Reading Regional Perfusion Research Research Personnel Research Priority Role Solutions Specific qualifier value System Techniques Technology Teflon Therapy Evaluation Time Tissues To specify Trauma patient United States National Institutes of Health Universities Wireless Technology abstracting base body system cell growth regulation commercialization contextual factors design design and construction experience improved in vivo instrument instrumentation minimally invasive novel optical fiber optical sensor phosphorescence pressure professor prototype public health relevance research study sensor tissue oxygenation tool

项目摘要

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) and our partners propose a minimally-invasive system for calibrated and repeatable measurement of peripheral tissue oxygenation. An optically coupled oxyphor-based micro-sensor approach is proposed based on Pd-tetrabenzoporphyrin modified with generation-3 polyarylglycine dendrons and coated with a layer of polyethylene glycol. Teflon AF chambers will be utilized to sequester the Oxyphor solution from contact with the body and the system provides a measurement of oxygen pressure by phosphorescence quenching. Sensor response time is estimated to be less than one minute with stability for greater than 16 hours. Advantages to the approach include a robust, quickly inserted and minimally invasive device with absolute calibration. In phase 1, a prototype system will be specified, developed, and evaluated.

描述（由申请人提供）：先进医疗电子 (AME) 和我们的合作伙伴提出了一种微创系统，用于校准和可重复测量周围组织氧合，提出了一种基于 Pd-四苯并卟啉修饰的光耦合微传感器方法。具有第 3 代聚芳基甘氨酸树枝状结构并涂有一层聚乙二醇的 AF 室将用于隔离 Oxyphor。溶液与身体接触，系统通过磷光猝灭提供氧压测量，传感器响应时间估计不到一分钟，稳定性超过 16 小时。该方法的优点包括坚固、快速插入和最小化。具有绝对校准的侵入式设备在第一阶段，将指定、开发和评估原型系统。