System for Measuring Tissue Oxygenation

组织氧合测量系统

基本信息

批准号：
8882628
负责人：
Gregory John Seifert
金额：
$ 15万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2016-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8882628
关键词：
Active Sites Affect Anesthesia procedures Biochemistry Biophysics Blood flow Caliber Calibration Clinic Clinical Collaborations Coupled Dendrimers Devices Doctor of Medicine Doctor of Philosophy Electron Transport Electronics Energy Metabolism Energy Transfer Engineering Ensure Erythrocyte Transfusion Erythrocytes Evaluation Fluorescence Funding Generations Hemorrhagic Shock Hour Image In Vitro Laboratories Length Marketing Measurement Measures Medical Medical Device Medical Electronics Medicine Metabolism Methods Microscopy Miniaturization Monitor Needles Optics Organ failure Organic Chemistry Oxygen Pathway interactions Patients Pediatrics Pennsylvania Performance Peripheral Peripheral Vascular Diseases Phase Physiological Polyethylene Glycols Positioning Attribute Principal Investigator Property Reaction Time Reading Regional Perfusion Research Research Personnel Research Priority Role Solutions Specific qualifier value System Techniques Technology Teflon Therapy Evaluation Time Tissues To specify Trauma patient United States National Institutes of Health Universities Wireless Technology abstracting base body system cell growth regulation commercialization contextual factors design design and construction experience improved in vivo instrument instrumentation minimally invasive novel optical fiber optical sensor phosphorescence pressure professor prototype public health relevance research study sensor tissue oxygenation tool

项目摘要

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) and our partners propose a minimally-invasive system for calibrated and repeatable measurement of peripheral tissue oxygenation. An optically coupled oxyphor-based micro-sensor approach is proposed based on Pd-tetrabenzoporphyrin modified with generation-3 polyarylglycine dendrons and coated with a layer of polyethylene glycol. Teflon AF chambers will be utilized to sequester the Oxyphor solution from contact with the body and the system provides a measurement of oxygen pressure by phosphorescence quenching. Sensor response time is estimated to be less than one minute with stability for greater than 16 hours. Advantages to the approach include a robust, quickly inserted and minimally invasive device with absolute calibration. In phase 1, a prototype system will be specified, developed, and evaluated.

描述（由适用提供）：高级医学电子（AME）和我们的合作伙伴提出了一个最小侵入性的系统，用于校准和可重复的外围组织氧合的测量。基于光学耦合的微传感器方法是基于用3代多氧化甘氨酸树突修饰的PD-Tetrabenzoporphyrin提出的，并用一层聚乙烯乙二醇涂层。 Teflon AF室将被用来隔离与人体接触的氧气溶液，并且该系统通过磷光猝灭提供了氧气压力的测量。传感器响应时间估计不到一分钟，稳定性超过16小时。该方法的优势包括具有绝对校准的强大，快速插入和微创装置。在阶段1中，将指定，开发和评估原型系统。