Low-Cost, Portable, Point of Care Amplitude-Integrated Electroencephalography (aEEG)

低成本、便携式、床旁幅值积分脑电图 (aEEG)

基本信息

批准号：
9315618
负责人：
Gregory John Seifert
金额：
$ 77.52万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2020-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9315618
关键词：
Affect Antiepileptic Agents Area Asphyxia Asphyxia Neonatorum Benign Birth Brain Injuries Caring Cerebrum Child Childhood Clinic Clinical Code Collaborations Collection Communities Community Hospitals Companions Computer software Consult Data Device or Instrument Development Devices Diagnosis Diagnostic Digital Signal Processing Early Diagnosis Electroencephalography Ensure Evaluation Family Practice Fright Goals Gold Hypoxia Infant Intensive Care Intervention Lead Letters Limb structure Medical Medical Electronics Medical center Modality Monitor Movement Names Neonatal Intensive Care Units Neonatology Neurologic Neurologic Dysfunctions Neurological outcome Neurologist Newborn Infant Nurseries Outcome Pediatrics Pharmaceutical Preparations Phase Physicians Population Production Provider Research Personnel Resources San Francisco Seizures Signal Transduction Specialist Status Epilepticus Subclinical Seizures System Technology Telemedicine Therapeutic Training Tremor United States base cost design design and construction experience improved instrument instrumentation natural hypothermia neonatal hypoxic-ischemic brain injury neonate pediatrician point of care portability professor prototype standard of care telehealth tool transmission process user-friendly

Affect Antiepileptic Agents Area Asphyxia Asphyxia Neonatorum Benign Birth Brain Injuries Caring Cerebrum Child Childhood Clinic Clinical Code Collaborations Collection Communities Community Hospitals Companions Computer software Consult Data Device or Instrument Development Devices Diagnosis Diagnostic Digital Signal Processing Early Diagnosis Electroencephalography Ensure Evaluation Family Practice Fright Goals Gold Hypoxia Infant Intensive Care Intervention Lead Letters Limb structure Medical Medical Electronics Medical center Modality Monitor Movement Names Neonatal Intensive Care Units Neonatology Neurologic Neurologic Dysfunctions Neurological outcome Neurologist Newborn Infant Nurseries Outcome Pediatrics Pharmaceutical Preparations Phase Physicians Population Production Provider Research Personnel Resources San Francisco Seizures Signal Transduction Specialist Status Epilepticus Subclinical Seizures System Technology Telemedicine Therapeutic Training Tremor United States base cost design design and construction experience improved instrument instrumentation natural hypothermia neonatal hypoxic-ischemic brain injury neonate pediatrician point of care portability professor prototype standard of care telehealth tool transmission process user-friendly

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项目摘要

Project Summary/Abstract The goal of this project is to develop a portable, low-cost tool to aid in the diagnosis and management of neonates born with neurologic complications. The project will develop instrumentation technology and associated software to enable early detection of neurologic brain injury and seizure activity for newborns delivered in care facilities that lack a full suite of neurological diagnostic tools. In neonates with birth asphyxia, seizures are very common and most frequently subclinical. Many studies have observed that even experienced clinicians have difficulty correctly identifying seizures in this population. Subsequently, clinical paroxysms that do not truly represent seizure are frequently over-treated and subclinical seizures, including status epilepticus, go unrecognized and untreated. As such, the use of continuous video‐electroencephalograph (EEG) monitoring is the gold standard for recognizing and treating seizures in this population. It is also very helpful at identifying which children have sustained brain injury, including hypoxia. This resource intense modality has become the standard of care at many tertiary medical centers but unfortunately remains unavailable to many clinicians at smaller birth facilities. Quantitative EEG, including the use of amplitude-integrated EEG (aEEG), has gained widespread use at most neonatal ICUs, and represents a more user-friendly bedside tool for identifying brain injury and seizures. The proposed phase II project aims to design, build, and evaluate a low- cost telemedicine-enabled aEEG monitor and associated multi-instrument software package that supports widespread use of aEEG in community-based birth / care facilities.