Low-Cost, Portable, Point of Care Amplitude-Integrated Electroencephalography (aEEG)

低成本、便携式、床旁幅值积分脑电图 (aEEG)

基本信息

批准号：
9194546
负责人：
Gregory John Seifert
金额：
$ 49.21万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9194546
关键词：
Affect Antiepileptic Agents Area Asphyxia Asphyxia Neonatorum Benign Birth Brain Injuries Caring Cerebrum Child Childhood Clinic Clinical Code Collaborations Collection Communities Community Hospitals Companions Computer software Consult Data Device or Instrument Development Devices Diagnosis Diagnostic Digital Signal Processing Early Diagnosis Electroencephalography Ensure Evaluation Family Practice Fright Goals Gold Hypoxia Infant Intensive Care Intervention Lead Letters Limb structure Marketing Medical Medical Electronics Medical center Modality Monitor Movement Names Neonatal Intensive Care Units Neonatology Neurologic Neurologic Dysfunctions Neurological outcome Neurologist Newborn Infant Nurseries Outcome Pediatrics Pharmaceutical Preparations Phase Physicians Population Production Provider Research Personnel Resources San Francisco Seizures Signal Transduction Specialist Status Epilepticus Subclinical Seizures System Technology Telemedicine Therapeutic Training Tremor United States abstracting base cost design design and construction experience improved instrument instrumentation natural hypothermia neonatal hypoxic-ischemic brain injury neonate pediatrician point of care professor prototype standard of care telehealth tool transmission process user-friendly

Affect Antiepileptic Agents Area Asphyxia Asphyxia Neonatorum Benign Birth Brain Injuries Caring Cerebrum Child Childhood Clinic Clinical Code Collaborations Collection Communities Community Hospitals Companions Computer software Consult Data Device or Instrument Development Devices Diagnosis Diagnostic Digital Signal Processing Early Diagnosis Electroencephalography Ensure Evaluation Family Practice Fright Goals Gold Hypoxia Infant Intensive Care Intervention Lead Letters Limb structure Marketing Medical Medical Electronics Medical center Modality Monitor Movement Names Neonatal Intensive Care Units Neonatology Neurologic Neurologic Dysfunctions Neurological outcome Neurologist Newborn Infant Nurseries Outcome Pediatrics Pharmaceutical Preparations Phase Physicians Population Production Provider Research Personnel Resources San Francisco Seizures Signal Transduction Specialist Status Epilepticus Subclinical Seizures System Technology Telemedicine Therapeutic Training Tremor United States abstracting base cost design design and construction experience improved instrument instrumentation natural hypothermia neonatal hypoxic-ischemic brain injury neonate pediatrician point of care professor prototype standard of care telehealth tool transmission process user-friendly

展开

项目摘要

Project Summary/Abstract The goal of this project is to develop a portable, low-cost tool to aid in the diagnosis and management of neonates born with neurologic complications. The project will develop instrumentation technology and associated software to enable early detection of neurologic brain injury and seizure activity for newborns delivered in care facilities that lack a full suite of neurological diagnostic tools. In neonates with birth asphyxia, seizures are very common and most frequently subclinical. Many studies have observed that even experienced clinicians have difficulty correctly identifying seizures in this population. Subsequently, clinical paroxysms that do not truly represent seizure are frequently over-treated and subclinical seizures, including status epilepticus, go unrecognized and untreated. As such, the use of continuous video‐electroencephalograph (EEG) monitoring is the gold standard for recognizing and treating seizures in this population. It is also very helpful at identifying which children have sustained brain injury, including hypoxia. This resource intense modality has become the standard of care at many tertiary medical centers but unfortunately remains unavailable to many clinicians at smaller birth facilities. Quantitative EEG, including the use of amplitude-integrated EEG (aEEG), has gained widespread use at most neonatal ICUs, and represents a more user-friendly bedside tool for identifying brain injury and seizures. The proposed phase II project aims to design, build, and evaluate a low- cost telemedicine-enabled aEEG monitor and associated multi-instrument software package that supports widespread use of aEEG in community-based birth / care facilities.

项目摘要/摘要该项目的目的是开发一种便携式，低成本的工具，以帮助诊断和管理有神经系统并发症的新生儿。该项目将开发仪器技术，并相关的软件可以早期检测新生儿的神经系统脑损伤和癫痫发作活性在缺乏一套神经系统诊断工具的护理机构中提供。在出生窒息的新生儿中，癫痫发作非常普遍，最常见的是亚临床。许多研究观察到甚至经历了临床医生难以正确识别该人群的癫痫发作。随后，临床阵发性不要真正代表癫痫发作经常被过度治疗和亚临床癫痫发作，包括癫痫持续状态，无法识别和未经处理。因此，使用连续视频 - 电脑摄影（EEG）监测是识别和治疗该人群癫痫发作的黄金标准。这也非常有帮助确定哪些儿童患有脑损伤，包括缺氧。这种资源强烈的方式具有成为许多三级医疗中心的护理标准，但不幸的是，许多人仍然无法使用较小的出生设施的临床医生。定量脑电图，包括使用放大器集成的脑电图（AEEG），在大多数新生儿ICU上都可以使用宽度，并且代表了一种更具用户友好的床头工具识别脑损伤和癫痫发作。拟议的II期项目旨在设计，建造和评估低 - 支持远程医疗的AEEG监视器和相关的多功能器软件包，以支持在基于社区的出生 /护理机构中使用AEEG的宽度使用。