Enhanced Imaging for Visual Prostheses

视觉假肢的增强成像

基本信息

批准号：
10483085
负责人：
Gregory John Seifert
金额：
$ 73.11万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10483085
关键词：
Businesses Clinical Trials Collaborations Color Communities Computer software Data Development Diabetic Retinopathy Disease Doctor of Philosophy Documentation Electric Stimulation Environment Evaluation Eye Eye Injuries Financial compensation Funding Glaucoma Grant Head Home Image Image Enhancement Imagery Individual Institutes Instruction Lead Light Macular degeneration Medical Medical Electronics Modality Ocular Prosthesis Ophthalmology Panthera leo Participant Penetration Persons Phase Pilot Projects Principal Investigator Process Production Prosthesis Readiness Rehabilitation Centers Rehabilitation therapy Research Resolution Retina Retinitis Pigmentosa Self-Help Devices Silicon Small Business Innovation Research Grant Software Validation System Techniques Technology Temperature Test Result Testing Time Training Training Programs Translating Trauma Universities Visible Radiation Vision Vision research Visual Visual Cortex Visual Perception Visual impairment Visually Impaired Persons Work base blind cohort commercialization design experience imager imaging modality imaging system improved intelligent algorithm medical schools multidisciplinary optic nerve disorder programs prosthesis wearer prototype retina implantation retinal prosthesis sensor verification and validation vision aid vision rehabilitation

项目摘要

Project Summary/Abstract The proposed project relates to the commercialization of a promising new thermal/visual imaging system to be used as an input modality to visual prostheses and other low vision aids. Visual prostheses, including Second Sight's Argus® II retinal prosthesis, which restores partial vision to people blinded by diseases such as retinitis pigmentosa and macular degeneration, and Second Sight's Orion® visual cortical prosthesis, which restores partial vision to people blinded by diseases such as retinitis pigmentosa, macular degeneration, glaucoma, diabetic retinopathy, eye injury/trauma, optic nerve disease etc., use cameras or other sensors to provide electrical stimulation directly to the retina or visual cortex of the user to elicit visual perception. Unfortunately, ordinary light and color information is difficult for wearers to effectively process in many important tasks with the limited perceived spatial resolution of the prostheses and other low vision aids. Current compensation techniques in reduced resolution systems apply enhancement, magnification, and panning of visible light imagery, and these techniques have utility. However, as we have convincingly demonstrated in phases I and II of the SBIR-supported development project, other types of imaging more naturally align with the limited resolution of visual prostheses in important tasks such as people finding and mobility. In this proposed CRP project, we will advance the phase II developed production-prototype system into commercial production and complete all required verification and validation testing to achieve FDA approval. Completed production systems will be distributed to prosthesis recipients who will undergo training in their use and then be allowed to evaluate the system in their home and community environment. Through these evaluations the end utility of the system in real-world use will be evaluated.

项目概要/摘要拟议的项目涉及一种有前途的新型热/视觉成像系统的商业化用作视觉假体和其他低视力辅助设备（包括第二视觉假体）的输入方式。 Sight 的 Argus® II 视网膜假体可以帮助因视网膜炎等疾病失明的人恢复部分视力色素变性和黄斑变性，以及 Second Sight 的 Orion® 视觉皮质假体，可恢复因视网膜色素变性、黄斑变性、青光眼等疾病致盲的人的部分视力糖尿病视网膜病变、眼睛损伤/外伤、视神经疾病等，使用相机或其他传感器来提供不幸的是，电刺激直接作用于用户的视网膜或视觉皮层以引发视觉感知。佩戴者很难在许多重要任务中有效处理普通的光和颜色信息假肢和其他低视力辅助设备的感知空间分辨率有限。降低分辨率系统中的技术应用可见光的增强、放大和平移然而，正如我们在第一阶段和第二阶段令人信服地证明的那样，这些技术是有用的。在 SBIR 支持的开发项目中，其他类型的成像更自然地与有限的在这个拟议的 CRP 中，视觉假体在重要任务中的分辨率，例如人员查找和移动。项目中，我们将把二期开发的量产样机系统推进商业化生产，完成所有必需的验证和确认测试，以获得 FDA 批准完成生产。系统将分发给假肢接受者，他们将接受使用培训，然后被允许通过这些评估来评估系统在他们的家庭和社区环境中的最终效用。将评估实际使用中的系统。