FrostBite - A Unique Catheter for Endoscopic Cryoablation

FrostBite - 用于内窥镜冷冻消融的独特导管

• 批准号: 8647726
• 负责人: John M BAUST
• 金额: $ 22.5万
• 依托单位: CELL PRESERVATION SERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-06 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647726
• 关键词: Ablation; Address; Adoption; Adverse effects; Area; Biomedical Engineering; Cancer Patient; Carcinoma in Situ; Cardiac ablation; Catheters; Cell Therapy; Clinical; Clinical Sciences; Cost Savings; Coupled; Cryosurgery; Development; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Disease; Endoscopes; Evolution; Frostbite; Gastroenterologist; Healthcare Systems; Image; Imaging Techniques; In Situ; Incidence; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Medical Device; Medicine; Methodology; Nature; Needles; Nitrogen; Operative Surgical Procedures; Outcome; Pancreas; Pancreatic Diseases; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Phase; Procedures; Program Development; Recurrence; Renal carcinoma; Reporting; Risk; Series; Side; Staging; Survival Rate; System; Technology; Testing; Therapeutic; Time; Tissue Engineering; Tissue Model; Tissues; Treatment Protocols; Ultrasonography; base; cancer therapy; combat; combinatorial; cost; cryobiology; design; effective therapy; experience; flexibility; gastrointestinal; gene therapy; improved; in vivo; innovation; medical schools; minimally invasive; mortality; next generation; novel; prototype; public health relevance; research and development; therapy design

There is a pressing need for designing new devices facilitating the development of paradigm changing, minimally invasive, approaches to treat diseased tissues in situ. Additionally, there is a growing number of studies showing that combinatorial approaches are providing a path for personalization of strategies to treat a wide array of disease states. While providing a promising path to revolutionize medicine, the evolution of personalized, minimally invasive, combinatorial therapies has been slowed as a result of technological limitations. As such, there is a pressing need for new medical devices to enable the development of trans-disciplinary strategies to combat disease. This Phase 1 project is designed to address this need through the development of a new flexible endoscopic compatible catheter designed for the treatment of various gastrointestinal related tissue diseases enabling the application of multiple therapeutic and diagnostic approaches (pharmaceutical, dual-ablation, cell and gene therapy, among others) in a single device format (FrostBite). The ability to deliver multi- parametric treatment regimes of the FrostBite catheter is enhanced by its compatibility with advanced imaging approaches including endoscopic ultrasound, MRI, and CT. Initial R&D activities have resulted in a prototype 1.5mm needle tip catheter capable of delivering dual thermal insults to a target within 10 seconds creating a zone of destruction of ~2.5cm in less than 2 mins. Preliminary studies into combinatorial drug/thermal insults have shown improved outcomes in tissue models as well. Under this proposal we intend to develop and test this next generation endoscopic compatible catheter as well as evaluate a series of combinatorial strategies. Successful completion of this project will provide for a novel medical device enabling the development and application of advanced personalized treatment regimes for 100's of thousands of patients who suffer from numerous gastrointestinal tissue disease states which are untreatable or inadequately treated with today's state of the art devices.

迫切需要设计新设备，以促进范式改变的开发， 微创的方法是原位治疗患病组织的方法。此外，还有一个增长 研究的数量表明，组合方法为个性化提供了一条途径 治疗各种疾病状态的策略。同时提供有前途的革命道路 医学，个性化，微创，组合疗法的演变已减慢 由于技术局限性。因此，有迫切需要新的医疗设备 使跨学科策略的发展能够打击疾病。这个阶段1项目是 旨在通过开发新的柔性内窥镜兼容来满足这一需求 旨在治疗各种胃肠道相关组织疾病的导管 应用多种治疗和诊断方法（药物，双燃料，细胞和细胞 基因治疗等）以单个装置格式（冻伤）。交付多种多样的能力 冻伤导管的参数治疗方案通过与先进的兼容性增强 成像方法包括内窥镜超声，MRI和CT。最初的研发活动已导致 在原型1.5mm针尖导管中，能够在10之内向目标传递双热侮辱 几秒钟在不到2分钟的时间内造成约2.5厘米的破坏区域。初步研究 组合药物/热侮辱也显示出在组织模型中的预后改善。在此 提案我们打算开发和测试这一下一代内窥镜兼容导管以及 评估一系列组合策略。成功完成该项目将提供 新颖的医疗设备，可以开发和应用高级个性化治疗 成千上万患有众多胃肠道疾病的100名患者的制度 无法治疗或不足以接受当今最先进的设备的状态。

项目成果

Investigation of the Impact of Cell Cycle Stage on Freeze Response Sensitivity of Androgen-Insensitive Prostate Cancer.

细胞周期阶段对雄激素不敏感前列腺癌冷冻反应敏感性影响的研究。

• DOI: 10.1177/1533034616648059
• 发表时间: 2016
• 期刊: Technology in cancer research & treatment
• 影响因子: 2.8
• 作者: Santucci,KimberlyL;Baust,JohnM;Snyder,KristiK;VanBuskirk,RobertG;Baust,JohnG
• 通讯作者: Baust,JohnG