Automated Device for High Throughput Cell Cryopreservation

高通量细胞冷冻保存自动化设备

• 批准号: 8059022
• 负责人: John M BAUST
• 金额: $ 35.04万
• 依托单位: CELL PRESERVATION SERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8059022
• 关键词: Animals; Antibodies; Area; Atrial Fibrillation; Basic Science; Biocompatible Materials; Biological; Biological Preservation; Biological Products; Biological Sciences; Biomedical Engineering; Biosensor; Biotechnology; Cell Death; Cell Survival; Cell Therapy; Cell physiology; Cells; Cellular Stress; Coupling; Cryopreservation; Cryopreserved Cell; Cultured Cells; Data; Dental; Development; Device Designs; Devices; Diagnostic; Engineering; Fluorescence; Freezing; Goals; Growth; Hour; Human; Human Resources; Industry; Laboratories; Life; Link; Malignant Neoplasms; Medical; Molecular Biology; Monitor; Monoclonal Antibodies; Natural regeneration; Nitrogen; Pathway Analysis; Pathway interactions; Phase; Procedures; Process; Production; Proteins; Protocols documentation; Reader; Reproducibility; Research; Sampling; Science; Screening procedure; Solutions; Source; Stem Cell Research; Stress; System; Technology; Temperature; Testing; Therapeutic; Time; Time Management; Tissue Engineering; Tissues; Translational Research; Urethra; Vial device; Wound Healing; anticancer research; bioprocess; cell bank; cost; cost effective; design; drug discovery; experience; flexibility; gene therapy; hypothermosol; improved; innovation; instrument; interest; manufacturing process; new technology; novel; novel strategies; product development; prototype; response; scale up; stem cell therapy; technology development; theories; tool; user-friendly

DESCRIPTION (provided by applicant): The "cultured cell" has emerged as a critical link in the translation of research in the various fields of biotechnology and biomedicine. An unprecedented increase in the demand for cultured cell products is now driven by the growth in biopharmaceuticals, cancer research, cell and gene therapy and stem cell research. These industries now rely on dated, low-volume, non-standardized technologies to bank cells in the daily production of their critical cellular tool. CPSI Biotech is developing an innovative controlled rate freezing device, RapidCP", designed to rapidly freeze biological samples while maintaining sample quality and functionality. This Phase 1 proposal focuses on the development of an innovative research/ cell processing device, RapidCP" - a device designed to enable the high throughput freezing of samples for application in the bioprocessing, cell therapy, drug discovery, and basic sciences arena. Further, the design of the technology will allow for multiple independent cooling blocks thereby allowing for continuous processing of manageable lot sizes. This will reduce sample backlog, alleviate time constraints and allow more effective sample processing. This proposal represents an integrative approach to product development coupling engineering, and life sciences PUBLIC HEALTH RELEVANCE: This proposal is designed to develop a rapid cryopreservation device that more effectively cryopreserves cells than current instruments and protocols. A prototype device has already been developed and the preliminary data support the theory that such a device can be developed and be of interest to a variety of interested parties.

描述（由申请人提供）：在生物技术和生物医学各个领域的研究翻译中，“培养的细胞”已成为关键联系。现在，对培养细胞产物的需求的前所未有的增加是由生物药物，癌症研究，细胞和基因治疗和干细胞研究的增长驱动的。这些行业现在依靠过时的，小批量的，非标准化的技术来每天生产其关键细胞工具。 CPSI Biotech正在开发一种创新的控制速率冷冻设备RapidCP”，旨在快速冻结生物样品，同时保持样本质量和功能。该阶段1提案着重于开发创新的研究/细胞处理设备RapparCP“ - 一种旨在使样品在生物群中促进样品的高渗透率，以实现生物疗法，以实现生物疗法，以实现生物疗法，并进行良好的培训。此外，该技术的设计将允许多个独立的冷却块，从而可以连续处理可管理的地块。这将减少样本积压，减轻时间限制并允许更有效的样品处理。该建议代表了产品开发耦合工程和生命科学的一种综合方法 公共卫生相关性：该提案旨在开发一种快速的冷冻保存装置，该设备比当前的工具和协议更有效地冷冻保存。已经开发了一种原型设备，并且初步数据支持了可以开发这种设备并引起各种兴趣方面的理论。