Development of an In Situ Anhydrobiotic Tissue Culture Process

原位脱水组织培养工艺的开发

基本信息

批准号：
7481983
负责人：
John M BAUST
金额：
$ 25.15万
依托单位：
CELL PRESERVATION SERVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-15 至 2009-11-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7481983
关键词：
Address Apoptosis Biochemical Biological Biological Preservation Biological Process Biotechnology Cell Cycle Cell Cycle Progression Cell Cycle Stage Cell Death Cell Line Cell Survival Cell physiology Cells Cellular Stress Response Class Complement 3a Cryopreservation Cultured Cells Cytochromes Depth Desiccation Development Disruption Drug Formulations Engineering Event Failure Fas Signaling Pathway Freezing Hepatocyte Hour Human In Situ Industry Investigation Knowledge Life Maintenance Mammalian Cell Mediating Membrane Metabolic Methods Mitochondria Modification Molecular Necrosis Organ Organism Oxidative Stress Pathway interactions Pharmacologic Substance Phase Physiological Process Production Public Health Recovery Regenerative Medicine Rehydrations Research Research Proposals Role Services Signal Transduction Signaling Molecule Small Business Funding Mechanisms Small Business Innovation Research Grant Staging Standards of Weights and Measures Stem Cell Research Stem cells Surface System Techniques Technology Testing Therapeutic Thinking Time Time Management Tissue Engineering Tissues Today base biodefense biological adaptation to stress caspase-9 cell type cold temperature concept day design drug discovery human AMID protein improved information gathering innovative technologies keratinocyte natural hypothermia novel receptor research and development response restoration stem cell therapy tissue culture

项目摘要

DESCRIPTION (provided by applicant): Cell Preservation Services, Inc. (CPSI) is an early stage biotechnology company that intends to develop a unique technology that will facilitate both the time- management and worldwide distribution of human cell cultures in a manner that currently does not exist. Under this SBIR, CPSI intends to develop a ready-to- use pre-seeded cell culture product, DryPlates", for several cell types, including standard cell lines, primary cells, such as keratinocytes or hepatocytes, and progenitor cells. This technology will allow users on-demand access to cells for high-throughput usage while eliminating the need for extensive handling and culturing of cells prior to utilization. The design of DryPlates" products provides for the long-term stable non-frozen storage of biologicals in a convenient format, easily integratable with current methods. CPSI intends to investigate the cellular and molecular components of the anhydrobiotic process to develop a technology and method of production of DryPlates" to meet the needs of industry, including pharmaceutical drug discovery, biodefense and stem cell research. PUBLIC HEALTH RELEVANCE: This proposal is designed to develop a unique and innovative technology for the worldwide distribution of human cell cultures to be used in the pharmaceutical and biomedical industries.

描述（由申请人提供）：Cell Preservation Services，Inc。（CPSI）是一家早期的生物技术公司，旨在开发一种独特的技术，该技术将促进人类细胞文化的时间管理和全球分布，以目前的方式进行不存在。在此SBIR下，CPSI打算开发现成的预先种子细胞培养产品，干板”，用于几种细胞类型，包括标准细胞系，主要细胞，例如角质形成细胞或肝细胞和祖细胞。该技术将允许用户按需访问细胞进行高通量使用，同时消除了在使用时进行广泛处理和培养细胞的需求。格式，易于与当前方法集成。 CPSI打算调查赤铁生物过程的细胞和分子成分，以开发一种干燥物的技术和生产方法“满足行业的需求，包括药物发现，生物探索和干细胞研究。开发一种独特而创新的技术，用于用于制药和生物医学行业的人类细胞培养物的全球分布。