Alcohol Consumption and Cardiovascular Health Among Older Couples: The Roles of Genetics and Marital Quality

老年夫妇的饮酒量和心血管健康：遗传和婚姻质量的作用

• 批准号: 10240609
• 负责人: KIRA S BIRDITT
• 金额: $ 40.58万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240609
• 关键词: Address; Adult; Affect; Age; Aging; Alcohol consumption; Alcohols; Baby Booms; Biological; Blood Pressure; Buffers; Calibration; Cardiovascular Diseases; Cause of Death; Chronic; Chronic Disease; Consumption; Couples; Data; Development; Discrimination; Disease; Drug abuse; Elderly; Generations; Genetic; Genetic Risk; Glycosylated hemoglobin A; Health; Heart Diseases; Heavy Drinking; Heritability; Husband; Hypertension; Individual; Intervention; Knowledge; Link; Marriage; Modeling; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physiological; Population; Predictive Factor; Prevalence; Public Health; Race; Reporting; Research; Retirement; Risk; Risk Factors; Role; Spouses; Stroke; Testing; Time; Wife; Woman; aging population; alcohol measurement; alcohol related problem; binge drinking; biopsychosocial; cardioprotection; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; design; drinking; drinking behavior; genetic information; high risk; innovation; insight; light effects; modifiable risk; mortality; prevent; prognostic model; prospective; protective factors; response; stress reactivity; waist circumference

Due to rapid population aging and more frequent and heavier drinking among the baby boom generation, an alarming rise is expected in the number of older adults with alcohol-related problems. At the same time, more than 50% of adults over age 55 in the U.S. have hypertension (HTN) and cardiovascular disease (CVD) remains the nation's leading cause of death. Alcohol use is strongly related to HTN and CVD, and moderation of alcohol is key for preventing and managing HTN in older adults. Although low levels of alcohol use can have cardioprotective effects, physiological changes, chronic illnesses, and medication use can make even small amounts of alcohol detrimental for cardiovascular health among older individuals. Marriage is a critical context for examining alcohol use and its effects on cardiovascular health. Over 60% of older adults are married and couples often engage in similar (i.e., concordant) drinking behaviors that can benefit marital quality, potentially establishing or maintaining problematic drinking patterns. Further, it is well established that CVDs and their biological risk factors are moderately to highly heritable, indicating that they are influenced by genetics. However, we know little about how alcohol use changes among couples as they age together or the marital and genetic factors that may make individuals and couples more resilient or vulnerable to CVD. In response to Accelerating the Pace of Drug Abuse Research Using Existing Data (PAR-16-234), the proposed project will use nationally representative longitudinal data from one of the largest studies of older couples (N = 8,545 married/cohabiting couples; 17,090 individuals) to address the following aims: 1) Identify alcohol use patterns among older couples over time and the demographic and contextual predictors of those patterns, 2) Determine the implications of individual and partner alcohol use for cardiovascular health and mortality among older couples over time, 3) Identify genetic and marital risk and protective factors linked to alcohol-related cardiovascular health and mortality among older couples, and 4) Develop and validate an innovative prognostic model to identify individuals and couples at high risk for poor cardiovascular health and mortality. Identifying individuals and couples who are most at risk or resilient to alcohol-related cardiovascular health problems and development of new prognostic models will generate key insights for designing and testing interventions to reduce these major public health threats among the growing population of aging adults.

由于人口迅速老龄化以及婴儿潮一代饮酒更加频繁和严重， 预计患有酒精相关问题的老年人数量将出现惊人的增长。同时， 在美国，超过 50% 的 55 岁以上成年人患有高血压 (HTN) 和心血管疾病 (CVD) 仍然是该国的首要死因。饮酒与 HTN 和 CVD 密切相关，适量饮酒 饮酒是预防和控制老年人高血压的关键。尽管少量饮酒可能会导致 心脏保护作用、生理变化、慢性疾病和药物使用甚至可以使很小的 饮酒量对老年人的心血管健康有害。婚姻是一个关键的背景 用于检查酒精使用情况及其对心血管健康的影响。超过60%的老年人已婚 夫妻经常有类似（即一致）的饮酒行为，这可能有利于婚姻质量 建立或维持有问题的饮酒模式。此外，众所周知，CVD 及其 生物风险因素具有中度至高度遗传性，表明它们受到遗传的影响。 然而，我们对随着年龄的增长，夫妻之间的饮酒情况如何变化或他们的饮酒情况知之甚少。 婚姻和遗传因素可能会使个人和夫妇更有弹性或更容易患心血管疾病。 为了响应《利用现有数据加快药物滥用研究步伐》(PAR-16-234)， 拟议的项目将使用来自最大的老年研究之一的全国代表性纵向数据 夫妇（N = 8,545 已婚/同居夫妇；17,090 人），以实现以下目标： 1) 确定 随着时间的推移，老年夫妇的饮酒模式以及人口和背景预测因素 这些模式，2) 确定个人和伴侣饮酒对心血管的影响 随着时间的推移，老年夫妇的健康和死亡率，3) 识别遗传和婚姻风险以及保护措施 老年夫妇中与酒精相关的心血管健康和死亡率相关的因素，4) 开发并验证创新的预后模型，以识别高风险的个人和夫妇 心血管健康状况不佳和死亡率。识别风险最大的个人和夫妇或 应对与酒精相关的心血管健康问题和新的预后模型的开发将 生成设计和测试干预措施的关键见解，以减少这些主要的公共卫生威胁 老年人口不断增长。