Autism Spectrum Disorder: Birth Cohort 1976-2000, Epidemiology and Adult Status

自闭症谱系障碍：出生队列 1976-2000，流行病学和成人状况

基本信息

批准号：
8792408
负责人：
SLAVICA K KATUSIC
金额：
$ 69.52万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-20 至 2016-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8792408
关键词：
19 year old 3 year old Academic achievement Address Adult Affect Alcohols Anesthesia procedures Antiepileptic Agents Asperger Syndrome Autistic Disorder Behavior Behavioral Symptoms Birth Calendar Caring Centers for Disease Control and Prevention (U.S.)Child Childhood Classification Clinic Clinical Code Cognition Cohort Studies Complex County DSM-IV Data Databases Development Diagnosis Diagnostic Diagnostic and Statistical Manual of Mental Disorders Dictionary Discipline of obstetrics Drug abuse Emergency Situation Emotional Environmental Risk Factor Epidemiologic Studies Epidemiology Etiology Expenditure Family Family history of Fathers Financial cost Folic Acid Funding Opportunities Future Gender Health Healthcare High Prevalence Home environment Human Incidence Incidence Study Individual Insurance Intelligence Intervention Knowledge Language Laws Learning Life Link Longitudinal Studies Measures Medical Medical Records Memory Mental disorders Mothers Natural History Outcome Outcomes Research Parents Perinatal Pervasive Development Disorder Pharmaceutical Preparations Phenotype Policies Pregnancy Prevalence Primary Prevention Prognostic Factor Provider Psychometrics Public Health Quality of life Recording of previous events Records Reporting Research Research Infrastructure Resource Allocation Resources Risk Factors Role Schools Scientific Advances and Accomplishments Services Siblings Societies Source Special Education Specific qualifier value Speech Study Subject Symptoms Testing Time Treatment Cost United States National Institutes of Health Vaccines abstracting autism spectrum disorder base birth control clinically relevant cohort cost cost effective design disorder prevention disorder subtype early childhood endophenotype experience improved in utero medical schools member phrases population based programs prospective psychologic psychosocial response risk sharing social time use trend

项目摘要

DESCRIPTION (provided by applicant): Autism Spectrum Disorders (ASDs) are lifelong neurodevelopmental conditions with mostly unknown etiology that have a huge impact on affected individuals and their families, and are a major public health concern. This proposal, "Autism Spectrum Disorder: Birth Cohort 1976-2000, Epidemiology and Adult Status," in response to NIH Funding Opportunity Announcement (PA-10-158) describes an epidemiologic, population-based, large birth cohort study of ASDs. Significant gaps exist in the knowledge of ASD incidence and its possible rising trend. Detailed characterization (phenotype) of ASD incident cases and ASD subtypes [Autistic Disorder (AD), Asperger's Syndrome (AS) and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS] is sparse, and potential risk factors (etiologies) are still unknown. Knowledge about adult outcomes of incident ASD cases identified in childhood is almost non-existent. ASD-associated medical costs are high, yet information to improve cost-effective medical management is lacking. A unique set of circumstances, including an already established population-based birth cohort of all children born 1976-2000 to mothers residing in Olmsted County, MN (N=43,934), access to complete, detailed school records for each child in the birth cohort (Independent School District ISD #535 - 41 public, private, home schooled), access to detailed medical records for every child in the birth cohort (Rochester Epidemiology Project-REP; NIH-AR30582), and the Olmsted County Healthcare Expenditure and Utilization Database (OCHEUD) provide the infrastructure to enable the successful completion of this project. This rigorous epidemiologic study involves an experienced multi-disciplinary research team, confirmation of the availability of documented behavioral symptoms of ASD from 1976 forward, with development of a detailed dictionary of descriptive phrases abstracted from medical/school records congruent with DSM-IV-TR criteria (pilot data) and a unique population-based birth cohort. [To help control for changes in special education laws and DSM criteria] this proposal will implement a systematic page by page review of medical and school records of all potential ASD cases regardless of initial school and medical classification and will apply the same uniform research criteria for ASD incident case identification (including DSM-IV-TR criteria), during the 37year study period. We will study the putative rise in incidence of ASD over 37 years, the possible role of certain risk factors on any incidence trend of ASD over time, the "shared risk" hypothesis by estimating the interaction between perinatal risk factors and family history (parents, siblings) of psychiatric disorders, assessing adult ASD current status and outcomes and cost effective medical management analyses. The knowledge achieved through this combined retrospective and prospective epidemiologic approach will substantially advance scientific/clinical knowledge about ASD. .

描述（由申请人提供）：自闭症谱系障碍（ASDS）是终身神经发育状况，其病因大多是对受影响的个人及其家人产生巨大影响，并且是一个主要的公共卫生问题。这项提议是“自闭症谱系障碍：1976 - 2000年出生队列，流行病学和成人地位”，以回应NIH资助机会公告（PA-10-158）描述了一项流行病学，基于人群的，基于人群的大型，大型的ASDS研究。在ASD发病率及其可能上升趋势的知识中存在很大的差距。 ASD事件病例和ASD亚型的详细表征（表型）[自闭症（AD），Asperger's综合征（AS）和未另有指定的普遍性发育障碍（PDD-NOS）（PDD-NOS）是稀疏的，潜在的风险因素（病因），并且未知的不知名是不知道的。缺乏具有成本效益的医疗管理。流行病学项目rep;这项严格的流行病学研究涉及一个经验丰富的多学科研究团队，确认了1976年从1976年开始的ASD的行为症状的可用性，并开发了从医疗/学校记录中抽象的详细描述性词典，该词与DSM-IV-TR-TR TRITERIA（PILOT数据）一致（PILOT数据）和基于人群的基于人群的出生人群。 [为了控制特殊教育法律和DSM标准的变化]本提案将在37年的研究期间，将对所有潜在ASD案件的医学和所有潜在ASD案件的医学和学校记录实施系统的审查，并将应用ASD事件案例识别（包括DSM-IV-TR标准）的相同统一的研究标准。我们将研究37年以上ASD的推定发病率上升，某些危险因素在随着时间的流逝的任何发生率趋势中的可能作用，即通过估算围产期危险因素与家族病史与家族史（父母，兄弟姐妹）之间的相互作用来评估成人ASD ASD现状和成本有效的医疗管理分析，这是“共同的风险”假设。通过这种回顾性和前瞻性流行病学方法获得的知识将大大提高有关ASD的科学/临床知识。。