EPIDEMIOLOGY OF LEARNING DISABILITY

学习障碍的流行病学

• 批准号: 2673702
• 负责人: SLAVICA K KATUSIC
• 金额: $ 22.52万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2673702
• 关键词: academic achievement; age difference; behavioral /social science research tag; bias; cognition; community; disease /disorder proneness /risk; dyslexia; family genetics; gender difference; human subject; interview; learning disorders; longitudinal human study; medical records; mental health epidemiology; middle childhood (6-11); prognosis; psychological tests; psychometrics; questionnaires; social behavior disorders; socioeconomics

A unique set of circumstances access to the resources of Independent School District #535 Student Support Services (which provides evaluation and management for the children from all public, parochial, and private schools in Rochester), of the privately owned Rochester Reading Center (which includes a pool of some 3,000 evaluations and outcomes of tutorial instruction that span nearly 50 years), and of the established Rochester Epidemiology Project (a richly-documented medical records-linkage system located at Mayo Clinic) -- will enable us to conduct a number of studies to further our knowledge of learning disabilities (LD) in a delineated population. For this study, LD will include dyslexia and problems related to writing, reasoning, and mathematics. These entities have long been recognized for their significant social, educational, and medical import. This study will produce estimates of the incidence of LD among a birth cohort of children, born 1976-1980 in Rochester, Minnesota, as well as to determine the prevalence of LD on August 1, 1992. Further, a nested case-control study will assess the association between factors from birth certificates and medical records, as well as a parent questionnaire, with risk of developing LD. We will estimate the amount of familial aggregation of LD and we will determine the genetic and non- genetic components that influenced any observed familial aggregation. Also, complex segregation analysis will be conducted with learning disabled incident cases as probands. We will assess the potential impact of referral biases inherent in referral-based studies of LD by comparing the population-based incident learning disabled cases with learning disabled cases (born during the same period of time) from the Mayo referral practice. Finally, the current status of incident cases, 1976- 1980, and their matched controls will be assessed using a group of standard psychological tests for each student to better understand the long-term outcomes of children with LD. Thus, at the conclusion of this study, we will have advanced our knowledge of the occurrence of LD, and provided new information about the etiology and familial aggregation of LD and further insight of the natural history/clinical course of the disorder.

一套独特的情况访问独立的资源 学区＃535学生支持服务（提供评估 以及所有公众，狭och和私人儿童的管理 罗切斯特的罗切斯特学校的学校 （其中包括大约3,000个评估和教程结果的池 近50年的指示）和已建立的罗切斯特（Rochester） 流行病学项目（一个有记录的病历连接系统 位于Mayo Clinic） - 将使我们能够进行许多研究 进一步了解我们的学习障碍知识（LD） 人口。 对于这项研究，LD将包括阅读障碍和问题 与写作，推理和数学有关。这些实体长期很长 因其重大的社会，教育和医学而被认可 进口。 这项研究将产生对LD发病率的估计 一个儿童的出生队列，出生于1976 - 1980年，在明尼苏达州罗切斯特（Rochester） 以及确定1992年8月1日LD的患病率。此外， 嵌套的病例对照研究将评估因素之间的关联 从出生证明和病历以及父母 问卷，有发展LD的风险。我们将估计金额 LD的家族性聚集，我们将确定遗传和非遗传和非 影响任何观察到的家族聚集的遗传成分。 此外，还将通过学习进行复杂的隔离分析 残疾事件案件作为检验。我们将评估潜在的影响 通过比较，基于转介的LD研究固有的推荐偏差 基于人群的事件学习障碍案例 梅奥（Mayo）的残疾病例（同期出生） 推荐实践。最后，1976年事件案件的现状 - 1980年，他们的匹配控件将使用一组 每个学生的标准心理测试，以更好地了解 LD儿童的长期结局。 因此，在此结束时 研究，我们将提高我们对LD发生的知识，并 提供了有关病因和家族汇总的新信息 LD和进一步了解自然历史/临床课程 紊乱。

项目成果

Early speech-language impairment and risk for written language disorder: a population-based study.

早期言语障碍和书面语言障碍的风险：一项基于人群的研究。

• DOI: 10.1097/dbp.0b013e31827ba22a
• 发表时间: 2013
• 期刊: Journal of developmental and behavioral pediatrics : JDBP
• 作者: Stoeckel,RuthE;Colligan,RobertC;Barbaresi,WilliamJ;Weaver,AmyL;Killian,JillM;Katusic,SlavicaK
• 通讯作者: Katusic,SlavicaK

Comparing Methods to Determine Persistence of Childhood ADHD Into Adulthood: A Prospective, Population-Based Study.

• DOI: 10.1177/1087054715618791
• 发表时间: 2018-04
• 期刊: Journal of attention disorders
• 影响因子: 3
• 作者: Barbaresi WJ;Weaver AL;Voigt RG;Killian JM;Katusic SK
• 通讯作者: Katusic SK

What can large population-based birth cohort study ask about past, present and future of children with disorders of development, learning and behaviour?

• DOI: 10.1136/jech-2016-208482
• 发表时间: 2017-04-01
• 期刊: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
• 影响因子: 6.3
• 作者: Katusic, Slavica K.;Colligan, Robert C.;Weaver, Amy L.
• 通讯作者: Weaver, Amy L.

Mediating and Moderating Role of Depression, Conduct Disorder or Attention-Deficit/Hyperactivity Disorder in Developing Adolescent Substance Use Disorders: A Population-Based Study.

• DOI: 10.1371/journal.pone.0157488
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yoshimasu K;Barbaresi WJ;Colligan RC;Voigt RG;Weaver AL;Katusic SK
• 通讯作者: Katusic SK

Academic Achievement in Adults with a History of Childhood Attention-Deficit/Hyperactivity Disorder: A Population-Based Prospective Study.

• DOI: 10.1097/dbp.0000000000000358
• 发表时间: 2017-01
• 期刊: Journal of developmental and behavioral pediatrics : JDBP
• 作者: Voigt RG;Katusic SK;Colligan RC;Killian JM;Weaver AL;Barbaresi WJ
• 通讯作者: Barbaresi WJ