Longitudinal Academic Performance in Children with a History of Neonatal Abstinence Syndrome

有新生儿戒断综合症病史的儿童的纵向学业表现

基本信息

批准号：
10349927
负责人：
Tammy E Corr
金额：
$ 19.94万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10349927
关键词：
3 year old Academic Medical Centers Academic achievement Accounting Achievement Adult Affect Age Biological Biometry Caregivers Caring Child Child Welfare Childhood Clinical Research Communities Community Health Complement Complex Conduct Clinical Trials Crime Data Databases Development Developmental Delay Disorders Diagnosis Drug Exposure Early Intervention Environment Epidemiology Family Foundations Future Generations Goals Grant Health Healthcare Illicit Drugs Incidence Individual Infant Influentials Information Systems Intervention Intervention Studies Interview K-Series Research Career Programs Learning Link Measures Mentorship Methodology Methods Mothers Neonatal Neonatal Abstinence Syndrome Newborn Infant Nursery Schools Opioid Outcome Parents Pennsylvania Performance Physicians Policies Pregnant Women Problem behavior Productivity Public Health Race Recording of previous events Reporting Research Research Design Research Methodology Research Personnel Resolution Resources Risk School-Age Population Schools Scientist Services Severities Social Environment Social Welfare Socioeconomic Factors Special Education Symptoms Syndrome Testing Time Toddler Training Translating United States National Institutes of Health United States Substance Abuse and Mental Health Services Administration Withdrawal achievement test career development clinical practice cost data warehouse design diagnosis evaluation drug exposure in utero early childhood effective intervention experience improved improved outcome in utero inattention neonate neurodevelopment opioid epidemic patient oriented postnatal research and development sex success

3 year old Academic Medical Centers Academic achievement Accounting Achievement Adult Affect Age Biological Biometry Caregivers Caring Child Child Welfare Childhood Clinical Research Communities Community Health Complement Complex Conduct Clinical Trials Crime Data Databases Development Developmental Delay Disorders Diagnosis Drug Exposure Early Intervention Environment Epidemiology Family Foundations Future Generations Goals Grant Health Healthcare Illicit Drugs Incidence Individual Infant Influentials Information Systems Intervention Intervention Studies Interview K-Series Research Career Programs Learning Link Measures Mentorship Methodology Methods Mothers Neonatal Neonatal Abstinence Syndrome Newborn Infant Nursery Schools Opioid Outcome Parents Pennsylvania Performance Physicians Policies Pregnant Women Problem behavior Productivity Public Health Race Recording of previous events Reporting Research Research Design Research Methodology Research Personnel Resolution Resources Risk School-Age Population Schools Scientist Services Severities Social Environment Social Welfare Socioeconomic Factors Special Education Symptoms Syndrome Testing Time Toddler Training Translating United States National Institutes of Health United States Substance Abuse and Mental Health Services Administration Withdrawal achievement test career development clinical practice cost data warehouse design diagnosis evaluation drug exposure in utero early childhood effective intervention experience improved improved outcome in utero inattention neonate neurodevelopment opioid epidemic patient oriented postnatal research and development sex success

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项目摘要

Project Summary/Abstract The objectives of this project are to more thoroughly understand the relationship between neonatal abstinence syndrome (NAS) and longitudinal academic performance. NAS is a withdrawal condition due to in utero drug exposure, most commonly opioids. The syndrome affects more than 32,000 newborns annually in the U.S., and its incidence continues to rise. Researchers report poorer development in toddler and preschool years, higher rates of inattention and behavioral problems, and worse and deteriorating school performance in children with a history of NAS, indicating the effects of NAS may last well beyond the newborn period. However, these existing studies do not sufficiently account for the complex interaction of biologic, health, and socioenvironmental influences on childhood development. Thus, the relationship between NAS and long-term neurodevelopment and academic achievement remains largely unknown. As school achievement is directly associated with adult productivity and negatively correlated with participation in crime, a better understanding of NAS and academic performance is urgently needed to optimize outcomes across a lifetime. This proposal aims to assess the independent relationship between NAS, NAS severity, NAS treatment, in utero drug exposure and longitudinal academic performance after controlling for relevant biologic, health, and socioenvironmental variables; to explore the moderator effects of early community and school resource support on NAS; and to learn how families’ school experiences may explain childhood academic performance. The former aims will be accomplished using an inclusive, uniquely-integrated South Carolinian data warehouse. With this data system, a child with a diagnosis of NAS can be linked with his/her mother, and the dyad can be followed so that a broad range of childhood outcomes can be examined in the context of relevant, influential factors. In addition, through qualitative interviews with parents and guardians of children with a history of NAS followed at a Pennsylvania academic medical center, the project will 1) explore if and how caregivers’ experiences regarding early community and school resource support are related to childhood academic performance and 2) analyze themes that emerge around barriers and facilitators of academic achievement in children with NAS. Under this career development award, the applicant receives training in methodology of data-driven, public health studies and patient-oriented, clinical research design; epidemiology, mixed methodologies, community health, and applying public health principles to clinical practice; and moving research to policy. Successful completion of the project will not only provide data to serve as the foundation for future studies evaluating NAS outcomes and treatment, but, in addition to her training and mentorship plan, will prepare the applicant to become an independent physician-scientist able to conduct clinical trials aimed at improving outcomes of children affected by NAS.

项目摘要/摘要该项目的目标是更彻底地了解新生儿之间的关系禁欲综合征（NAS）和纵向学习成绩。 NAS是由于在子宫药物暴露，最常见的是阿片类药物。该综合征每年影响32,000多名新生儿美国及其事件继续上升。研究人员报告说，幼儿和学龄前的发展较差多年，注意力不集中和行为问题的率更高，并且在学校表现较差和恶化有NAS病史的儿童表明NAS的影响可能会超出新生儿时期。但是，这些现有研究不能充分说明生物学，健康和社会环境对儿童发展的影响。那，NAS与长期之间的关系神经发育和学术成就在很大程度上是未知的。因为学校成就直接与成人生产力相关，与参与犯罪的负面关系，更好地理解迫切需要NAS和学习成绩来优化一生的成果。该提案旨在评估NAS，NAS严重程度，NAS治疗之间的独立关系在控制相关生物学，健康和社会环境变量；探索早期社区和学校资源的主持人效应支持NAS；并了解家庭的学校经历如何解释童年的学业表现。前者将使用包容性的，独特的南卡罗来纳州数据来实现仓库。使用此数据系统，有NAS诊断的孩子可以与他/她的母亲联系在一起，可以遵循二元组，以便可以在相关的背景下检查各种各样的童年结果影响因素。此外，通过对父母和儿童的监护人的定性采访 NAS的历史在宾夕法尼亚州的一个学术医学中心遵循，该项目将1）探索是否以及如何护理人员在早期社区和学校资源支持方面的经验与童年有关学习成绩和2）分析围绕学术障碍和促进者出现的主题 NAS儿童的成就。根据该职业发展奖，适用健康研究和面向患者的临床研究设计；流行病学，混合方法，社区健康，并将公共卫生原则应用于临床实践；并将研究转移到政策。成功的该项目的完成不仅将提供数据以作为评估NAS的未来研究的基础成果和治疗，但是除了她的培训和指导计划外，还将准备申请人成为独立的身体科学家可以进行旨在改善结果的临床试验受NAS影响的儿童。