MEASUREMENT AND IMAGING CORE

测量和成像核心

• 批准号: 8333453
• 负责人: JAMES Anthony ASHTON-MILLER
• 金额: $ 21.85万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2012-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333453
• 关键词: Area; Behavior; Biomedical Engineering; Birth; Catheters; Clinical; Computer software; Data; Data Set; Image; Injury; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Modeling; Muscle; Operative Surgical Procedures; Pelvic Floor Muscle; Pelvic floor dysfunction; Pelvic floor structure; Pelvis; Property; Recovery; Second Labor Stage; Signal Transduction; Speculums; Time; Urethra; Vagina; Weight; Woman; image reconstruction; instrument; levator ani muscle; muscle strength; pressure

The Measurement and Imaging Core will assist with measurements of perineal geometry during the late second stage of labor in 50 women, and of pelvic floor load-displacement behavior in 32 women using a posterior weighted speculum at the time of pelvic surgery. The Core will assist with clinical measurements and standardized data sets from magnetic resonance (MR) imaging to be made on the 175 and 150 women completing Projects 2 and 3, respectively. In Projects 2 & 3, subject-specific pelvic floor model geometries will be developed from reconstructing the magnetic resonance (MR) images. Additionally, in Project 2 the post natal recovery of normal MR signal intensity will be tracked over time in the pubovisceral muscles. In Project 3, MR measurements of posterior vaginal wall geometry will be made. Lastly, the Core will provide bioengineering and technical support to each project. For Projects 2 & 3 it will provide technical support for all urethral pressure measurements (MUCPR and MUCPMvc) to be made using 8F catheter, maintain the hardware and software of the instrumented speculum used to measure levator ani contractile properties (LAR and I_AMVC,), and analyze and provide cleaned data sets to Core A for statistical analysis.

测量和成像核心将有助于测量晚期的几何几何形状 50名女性的第二阶段劳动阶段，以及32名女性的骨盆底负荷解散行为 骨盆手术时的后加权窥镜。核心将有助于临床测量 以及从175和150名女性制造的磁共振（MR）成像的标准化数据集 分别完成项目2和3。在项目2和3中，特定于主题的骨盆底模型几何形状 将从重建磁共振（MR）图像来开发。此外，在项目2中 正常MR信号强度的出生后恢复将随着时间的流逝而在耐肠肌中跟踪。在 项目3，将进行后阴道壁几何形状的MR测量。最后，核心将提供 每个项目的生物工程和技术支持。对于项目2和3，它将为 所有使用8F导管进行的所有尿道压力测量（MUCPR和MUCPMVC），保持 用于测量Levator ANI收缩特性的仪器镜的硬件和软件（lar 和I_AMVC），并分析并提供清洁的数据集，以核心A进行统计分析。