Biomechanics Core

生物力学核心

• 批准号: 10448479
• 负责人: JAMES Anthony ASHTON-MILLER
• 金额: $ 14.89万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448479
• 关键词: Affect; Aging; American; American Heart Association; Applications Grants; Award; Biological Markers; Biomechanics; Blood Vessels; Blood Volume; Capsicum; Cardiac; Collaborations; Computer Models; Consult; Data; Development; Diabetes Mellitus; Diagnosis; Disease; Economics; Elderly; Encephalopathies; Engineering; Equilibrium; Equipment; Extramural Activities; Extravasation; Faculty; Functional disorder; Geriatrics; Goals; Grant; Health; Impairment; Individual; Indwelling Catheter; Inflammation; Institution; Interdisciplinary Study; Internal Medicine; Intervention; Kidney Failure; Laboratory Research; Life Style; Liver Cirrhosis; Measurement; Measures; Mechanics; Mentorship; Metabolic Diseases; Methods; Modeling; Modification; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Outcome Measure; Output; Patients; Peer Review; Physical activity; Physicians; Physiological; Prevention; Productivity; Ptosis; Renal function; Research; Research Personnel; Research Project Grants; Risk; SECTM1 gene; Self Management; Services; Severities; Smooth Muscle; Sodium; Stream; Striated Muscles; Structure; System; Technology Transfer; Testing; Time; Training; Urethra; Urethral sphincter; Urinary Incontinence; Urine; Validation; age related; bench to bedside; black men; career development; comorbidity; computerized data processing; data acquisition; decubitus ulcer; design; fall injury; falls; functional status; hip replacement arthroplasty; improved; insight; interest; invention; investigator training; mathematical model; microsensor; models and simulation; motion sensor; novel; older women; pathomechanics; pelvic organ prolapse; prevent; processing speed; programs; ranpirnase; research clinical testing; software systems; sphincter ani muscle structure; success; wearable sensor technology

ABSTRACT The Biomechanics Core (BC) will facilitate the training of investigators in the conduct of new and expanded research on how metabolic disease and inflammation interact with age-related disease to determine key health outcomes. The Specific Aims include: providing interdisciplinary expertise, training and technical support for the biomechanical and other physiological aspects of Research Career Development, a Pilot Exploratory Study, a Developmental Project (DP) and 8 External Projects (EPs, Aim 1); providing individual guidance on (Aim 2) and evaluating methods (Aim 3) related to mobility and functional status, the biomechanics of aging, and to the training of geriatric physicians and other clinicians in the biomechanics relevant to impaired mobility, falls and fall-related injuries, urinary incontinence and prolapse in the older adults; and assisting with computer modeling and simulation related to the above goals (Aim 4). BC-supported investigators will have substantial access to the UM Biomechanics Research Laboratory of the Department of Mechanical Engineering and the Mobility Research Center at the UM Geriatrics Center. The DP will enhance a BC-invented uroflowmeter by designing and testing a microsensor to measure mid-stream urine sodium in real time. This modification will challenge the existing paradigm of needing an indwelling catheter to accurately measure urine output and urine biomarkers, and the invention will help differentiate kidney failure from normal kidney function with low blood volume. The EPs include improving the treatment of hip arthroplasty, urinary incontinence and pelvic organ prolapse, preventing decubitus ulcers, and wearable sensors to determine real world physical activity and falls in older adults. By structuring the BC as a separate Core, the OAIC achieves economic efficiencies in terms of reduced equipment and service that would be duplicated if separate biomechanics components were pursued by individual OAIC projects. Since its inception, the BC has served as a consulting service to faculty performing multidisciplinary research on geriatric mobility problems. Consequently, the BC has positively impacted the quality of the research conducted in and beyond the OAIC, as demonstrated by its productivity in terms of peer-reviewed articles, the success of young investigators granted with K08, K12, K23, K99/R00 awards, and extramural research projects awarded by R03, R21, R01, P50 and RC2 mechanisms.

抽象的 生物力学核心（BC）将促进调查人员进行新的和扩展的培训 关于代谢疾病和炎症如何与年龄相关疾病相互作用以确定关键健康的研究 结果。具体目的包括：为跨学科专业知识，培训和技术支持提供 研究职业发展的生物力学和其他生理方面，试点探索性 研究，一个发展项目（DP）和8个外部项目（EPS，AIM 1）；提供个人指导 （AIM 2）和评估方法（目标3）与移动性和功能状态有关的方法，衰老的生物力学， 以及培训与流动性障碍有关的生物力学中的老年医生和其他临床医生 老年人的跌倒和跌倒有关的伤害，尿失禁和脱垂；并协助计算机 与上述目标相关的建模和仿真（AIM 4）。 BC支持的调查人员将有大量 进入机械工程系的UM生物力学研究实验室和 UM老年中心的移动性研究中心。 DP将通过 设计和测试微型传感器以实时测量中游尿液中的钠。这种修改将 挑战需要留置导管以准确测量尿量和尿液的现有范式 生物标志物，本发明将有助于区分肾衰竭与正常肾功能和低血 体积。 EPS包括改善髋关节置换术，尿失禁和骨盆器官的治疗 脱垂，防止脱骨溃疡和可穿戴传感器，以确定现实世界的体育活动并跌落 在老年人中。通过将卑诗省构成单独的核心，OAIC从 如果采用单独的生物力学组件，则降低的设备和服务将重复 由个别OAIC项目。自成立以来，卑诗省一直是教师的咨询服务 对老年流动性问题进行多学科研究。因此，卑诗省有积极的 影响了OAIC内外研究的质量，这证明了其生产力 同行评审文章的条款，授予K08，K12，K23，K99/R00的年轻调查员的成功 由R03，R21，R01，P50和RC2机制授予的奖项和校外研究项目。