Bilingualism as a protective factor of ADRD in American Indian adults: the Strong Heart Study

双语是美洲印第安人成人 ADRD 的保护因素：强心脏研究

• 批准号: 10582307
• 负责人: Celestina Barbosa-Leiker
• 金额: $ 52.66万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582307
• 关键词: Acculturation; Adult; Affect; Age; Aging; Alzheimer' s disease related dementia; American; American Indians; Cognition; Cognitive; Communities; Crystallization; Data Collection; Dementia; Diagnosis; Education; Educational Status; Funding; Future; General Population; Generations; Geographic Locations; Heart; Impaired cognition; Individual; Interview; Language; Link; Liquid substance; Measurement; Measures; Modeling; Modification; National Heart, Lung, and Blood Institute; Not Hispanic or Latino; Persons; Population; Population Study; Prevalence; Prevention strategy; Public Health; Punishment; Questionnaires; Recording of previous events; Research; Risk; Risk Reduction; Role; Schools; Short-Term Memory; Socioeconomic Status; Standardization; United States; United States National Institutes of Health; Vocabulary; Vulnerable Populations; Work; aged; attentional control; bilingualism; cerebrovascular; cofactor; cognitive performance; cognitive reserve; cognitive testing; cohort; comorbidity; experience; federal policy; improved; instrument; mental state; performance tests; protective factors; psychologic; recruit; response; rho; sex; skills; social; treatment strategy

PROJECT SUMMARY/ABSTRACT American Indian populations have greater burden of cerebrovascular and Alzheimer’s disease and Related Dementias (ADRD) comorbidities compared with non-Hispanic White U.S. populations and may also have greater burden of cognitive decline and dementia. Bilingualism—common in American Indian communities— may enhance working memory capacity, attentional control, and cognitive reserve, thus reducing cognitive risk. However, bilingualism is a highly individual experience, and the context of use can modify its cognitive effects. Factors that may influence this association include age, sex, vocabulary, physical and mental status, socioeconomic status, culture, and social activity. Comprehensively assessing the relationship between bilingualism and cognitive performance may be critical to fully understanding ADRD in American Indian adults. Although the link between bilingualism and cognitive reserve has been studied in many populations, bilingualism research in American Indian populations has been limited, due in part to critical cofactors related to their experiences, perspectives, and standardized assessments. Unjust United States (U.S.) federal policies affecting American Indian people included forced attendance at English-speaking boarding schools where use of Native languages was punished, and cultural assimilation was prioritized over quality of education. As a result, bilingualism in American Indian adults who attended such schools may present differently than for other populations. Indeed, NIA (RFA-AG-23-001) defines bilingualism as “proficiency in two or more languages”, however no validated, detailed assessment of proficiency exists for U.S. Native languages, or for American Indian speakers of those languages. Our proposed study will be the first to culturally adapt a language use and history instrument in a large, heterogeneous American Indian population. In response to RFA-AG-23-001, we will leverage the Strong Heart Study, a large, longitudinal, heterogeneous, population-based study of aging in American Indian adults over 3 geographic regions (N=2,500). In this proposed work, we will build on this study, as well as our prior work, to assess the continuum of bilingualism in American Indian peoples by culturally adapting the Language History Questionnaire, evaluate bilingualism in American Indians of multiple generations in association with a detailed cognitive performance battery, and construct conceptual models to assess intervariable relationships including effect modification and moderation by crystallized cognition. This project will illuminate questions of public health significance in a vulnerable population that remains underrepresented in ADRD research, with potential implications for future prevention and treatment strategies.

项目摘要/摘要 美洲印第安人的脑血管和阿尔茨海默氏病及相关的人口更大 痴呆症（ADRD）合并症与非西班牙裔白人人口相比 认知能力下降和痴呆症的燃烧更大。双语主义 - 美洲印第安人社区的普通话 - 可能会增强工作记忆能力，注意力控制和认知储备，从而降低认知风险。 但是，双语主义是一种高度个人的经验，使用的背景可以改变其认知效果。 可能影响这种关联的因素包括年龄，性别，词汇，身心状况， 社会经济地位，文化和社会活动。全面评估 双语和认知表现对于完全了解美洲印第安人的ADRD可能至关重要。 尽管在许多人群中，双语和认知储备之间的联系已经研究了 美洲印第安人人口的双语研究受到限制，部分归因于关键辅助因子 根据他们的经验，观点和标准化评估。不公正的美国（美国）联邦政策 影响美洲印第安人的人包括强迫参加英语的寄宿学校 母语受到惩罚，文化同化优先于教育质量。作为 结果，参加此类学校的美洲印第安人的双语可能与其他学校的表现方式不同 人群。确实，NIA（RFA-AG-23-001）将双语主义定义为“两种或多种语言的熟练程度”， 但是，对于美国母语或美国 这些语言的印度说话者。我们拟议的研究将是第一个在文化上适应语言使用和 历史工具中的大型，异质的美洲印第安人人口。为了响应RFA-AG-23-001，我们 将利用强大的心脏研究，这是一项大型，纵向，异质，基于人群的衰老研究 美国印第安人3个地理区域（n = 2,500）。在这项拟议的工作中，我们将以这项研究为基础 以及我们先前的工作，以文化上评估美洲印第安人的双语连续性 调整语言史问卷调查，评估多重的美洲印第安人的双语 几代人与详细的认知性能电池合作，并构建概念模型 评估可干预的关系，包括通过结晶认知的效果修改和节制。这 项目将阐明依然存在的公共卫生意义的问题 在ADRD研究中的代表性不足，对未来的预防和治疗策略的潜在影响。