Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury Management

用于气道组织损伤管理的内窥镜多功能光学相干断层扫描

基本信息

批准号：
10081106
负责人：
NICUSOR IFTIMIA
金额：
$ 25.86万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10081106
关键词：
Acute Address Algorithmic Software Anatomy Animal Model Area Biopsy Bronchoscopes Bronchoscopy Burn Centers Burn injury Carbon Monoxide Catheters Cessation of life Clinical Collaborations Complement Complex Data Development Diagnosis Epithelial Epithelium Evaluation Excision Face Feedback Fire - disasters Gases Goals Government Histopathology Hospital Costs Hospitalization Human Hydrogen Cyanide Image Imaging Device Inhalation Inhalation Burns Inhalation Exposure Injury Liquid substance Lung Lung Transplantation Malignant Neoplasms Measures Monitor Morbidity - disease rate Morphology Nitrogen Dioxide North Carolina Operative Surgical Procedures Optical Coherence Tomography Outcome Patient Triage Patient-Focused Outcomes Patients Perfusion Persons Phase Physicians Population Reaction Research Resolution Resuscitation Severities Survival Rate Technology Testing Therapeutic Time Tissue Sample Tissues Triage United States Universities clinical examination experience imaging capabilities improved in vivo injured injured airway instrument mortality new technology novel optical imaging physical science prognostic programs residence screening smoke inhalation success tissue injury tool

项目摘要

Project Summary/Abstract Inhalation injury is an important cause of morbidity and mortality in the civilian population. It is usually caused by the inhalation of smoke or toxic gases, such as carbon monoxide, hydrogen cyanide, nitrogen dioxide, etc. Bronchoscopy is currently used as a standard approach for inhalation injury assessment. However, it fails to provide submucosal and functional tissue information, both of which are essential for proper triage and selection of appropriate therapy. Physical Sciences Inc., in collaboration with the University of North Carolina, Chapel Hill, proposes to develop a novel Endoscopic Multifunctional Optical Coherence Tomography instrument for Airway Tissue Injury Management that will provide clinicians with real-time feedback regarding the morphological and functional changes of the injured tissue. This instrument will complement qualitative bronchoscopic findings with quantitative submucosal morphological and functional information, such as ciliary activity and compliance, which will enable more efficient screening, triage, and therapeutic guidance of inhalation exposures. The goal of the Phase I program is to demonstrate the feasibility of the proposed technology for airway inhalation injury assessment, while in Phase II an advanced clinical instrument will be proposed to be developed and preliminarily tested on human patients of acute inhalation injury.

项目概要/摘要吸入性损伤是平民发病和死亡的重要原因。通常是由于吸入烟雾或有毒气体，如一氧化碳、氰化氢、二氧化氮等。支气管镜检查目前被用作吸入性损伤评估的标准方法。然而，它未能提供粘膜下和功能组织信息，这两者对于正确分类和选择至关重要的适当治疗。物理科学公司与北卡罗来纳大学教堂山分校合作，提议开发一种新型内窥镜多功能气道光学相干断层扫描仪组织损伤管理将为临床医生提供有关形态和组织损伤的实时反馈受伤组织的功能变化。该仪器将补充定性支气管镜检查结果定量粘膜下形态和功能信息，例如纤毛活动和顺应性，将使吸入暴露的筛查、分类和治疗指导更加有效。第一阶段计划的目标是证明所提议的气道技术的可行性吸入性损伤评估，而在第二阶段将建议开发先进的临床仪器并对急性吸入性损伤的人类患者进行了初步测试。