Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

用于皮肤癌检测和治疗指导的多模态光学探头

基本信息

批准号：
10224140
负责人：
NICUSOR IFTIMIA
金额：
$ 74.25万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-18 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10224140
关键词：
3-Dimensional Ablation Adoption Aftercare Agreement Area Biological Biopsy Caliber Cancer Detection Cicatrix Clinic Clinical Coagulation Process Cold Therapy Collaborations Complement Confocal Microscopy Curettage procedure Dermis Dermoscopy Diagnosis Diagnostic Imaging Dose Early Diagnosis Emotional Engineering Evaluation Excision Feedback Frequencies Goals Health Care Costs Histology Image Image Enhancement Imaging Device Imaging Techniques Imaging technology Incidence Lasers Lateral Lesion Magnetic Resonance Imaging Malignant Neoplasms Measurement Measures Memorial Sloan-Kettering Cancer Center Methods Mohs Surgery Morphology Mosaicism Multimodal Imaging Older Population Operative Surgical Procedures Optical Coherence Tomography Optics PUVA Photochemotherapy Patient Care Patients Pharmacotherapy Phase Physicians Prevalence Radiation Radiation therapy Recovery Recurrence Research Project Grants Residual Tumors Resolution Risk Screening for Skin Cancer Selection for Treatments Skin Skin Cancer Skin Carcinoma Source Specificity Specimen Speed System Technology Time Tissues Translating Trauma Trauma patient Triage Tumor Subtype Ultrasonography Validation Visit Visual aging population base cancer diagnosis cancer subtypes cancer therapy commercialization cost design dosage effective therapy healing imaging capabilities imaging probe improved instrument microscopic imaging multidisciplinary multimodality non-invasive monitor novel optical imaging patient population physical science programs prototype psychological trauma reconstruction side effect submicron success targeted treatment tool treatment planning tumor tv watching

项目摘要

Project Summary/Abstract The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as on performing the therapy. The increasing incidence and prevalence in skin cancer, especially among the aging population, combined with the high costs of surgery and subsequent reconstruction, and the physical and psychological trauma that patient endures with surgical intervention, has led to an increasing adoption and implementation of alternative non-surgical treatments that can be highly effective and less invasive. Laser ablation and radiotherapy have been proven to be effective therapies for common skin cancers and have the additional benefits that are easily tolerable and not associated with less scarring or disfigurement. Therefore, their clinical use has substantially increased within the recent years to treat skin cancers. However, the primary challenge in delivering effective laser fluence or radiotherapy dose for skin cancer is accurate delineation of the cancer target, both in depth and laterally. Fortunately, the unique capability of OCT/CM to visualize tissue morphology with micron-scale resolution can be used in real-time in the clinics to aid therapy target delineation and enable more precise delivery of therapy without need to “estimate” the subclinical extent of spread, thereby minimizing side effects. In addition, CM/OCT can be used to confirm eradication of skin cancer, which is currently limited to visual inspection, a highly insensitive and subjective method. The preliminary evaluation of the feasibility of this technology for aiding accurate target delineation will be performed during the Phase I program. Based on Phase I conclusions, the technology will be refined in Phase II and evaluated clinically on a large pool of patient population. Both therapy decision aiding and therapy guidance capabilities will be evaluated.

项目概要/摘要该研究项目的主要目标是开发一种新型光学成像并将其应用于临床基于光学相干断层扫描 (OCT) 和共焦显微镜 (CM) 相结合的技术，用于非非黑色素瘤皮肤癌 (NMSC) 的侵入式实时诊断、肿瘤亚型分析和边缘定位这将有助于医患在治疗计划中做出决定（活检与不活检、手术与非手术），以及进行治疗。皮肤癌的发病率和患病率不断增加，尤其是在老龄化人口中，由于手术和随后的重建费用高昂，以及身体和心理上的创伤，患者忍受手术干预，导致越来越多的人采用和实施替代疗法激光消融和放射治疗非常有效且侵入性较小。已被证明是治疗常见皮肤癌的有效疗法，并且具有容易获得的额外益处耐受性好，且与较少的疤痕或毁容无关，因此，它们的临床应用具有显着的意义。近年来治疗皮肤癌的药物有所增加，但主要挑战是提供有效的治疗。皮肤癌的激光能量密度或放射治疗剂量可以准确地描绘癌症目标，无论是深度还是深度幸运的是，OCT/CM 具有微米级可视化组织形态的独特能力。分辨率可在诊所实时使用，以帮助治疗目标描绘并实现更精确无需“估计”亚临床扩散程度即可提供治疗，从而最大限度地减少副作用。此外，CM/OCT可用于确认皮肤癌的根除，目前仅限于视觉检查是一种高度不敏感和主观的方法。该技术辅助精确目标描绘的可行性的初步评估将在根据第一阶段的结论，该技术将在第一阶段项目中进行完善。 II 期临床研究对大量患者群体进行了治疗决策辅助和治疗评估。将评估制导能力。