Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals

智能传感器用于指导通过硬膜外麻醉剂和止痛药物的安全输送

• 批准号: 10883933
• 负责人: NICUSOR IFTIMIA
• 金额: $ 3.58万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10883933
• 关键词: Anesthetics; Animals; Birth; Blindness; Cervical; Characteristics; Chemicals; Chronic neck pain; Engineering; Epidural Injections; Fiber; Headache; Health; Hospitals; Human; Infection; Interferometry; Laboratories; Light; Monitor; Needles; Noise; Operative Surgical Procedures; Optics; Pain; Pain Clinics; Paralysed; Patient-Focused Outcomes; Pharmaceutical Preparations; Phase; Procedures; Secondary to; Slipped Disk; Source; Specimen; Spinal Stenosis; Stroke; Syndrome; Technology; Testing; Tissue Differentiation; Tissues; United States National Institutes of Health; animal tissue; chronic pain; cost; discogenic pain; epidural space; experimental study; improved; nerve damage; new technology; novel; novel strategies; physical science; prototype; sensor; side effect

Project Summary/Abstract Physical Sciences Inc. (PSI) proposes to develop a novel approach for guiding safer delivery of pain and/or anesthetic drugs during epidural procedures (EPs). Epidural injections are typically used to treat pain from herniated discs, spinal stenosis, chemical discs, chronic pain secondary to post-cervical surgery syndrome, and chronic neck pain of discogenic origin. They are also regularly used to alleviate pain related to birth. However, when not properly performed, the epidural injections can have negative side effects, such as severe headache, infection, and even nerve damage. Serious side effects may also occur, including stroke, paralysis, or loss of vision. This proposal aims to overcome current issues related to epidural injections by using a novel and more reliable low coherence interferometry (LCI) optical sensing approach to determine what tissue type is present at the tip of the needle, while monitoring the force applied to the needle to safely pass it into the epidural space using a fiber Bragg sensor. During the Phase I effort PSSI has developed a laboratory prototype for epidural guidance that combines low coherence interferometry with Bragg sensing within the same probe. This approach was tested and optimized ex vivo on animal tissue specimens. Although feasibility was demonstrated, the differentiation of tissue types was somewhat impeded by the relatively high intensity noise of the light source owed by PSI and used in the experiments. Therefore, we request NIH support to purchase a better performing light source, as well as to cover the nonrecurring engineering cost of suitable Bragg gratings that better match the spectral characteristics of this light source. After improving the setup, the technology will be evaluated in live animals. Based on the Phase I findings, the technology will be further improved during Phase II and validated on humans at BWH.

项目概要/摘要 Physical Sciences Inc. (PSI) 提议开发一种新方法来指导更安全的疼痛传递 和/或硬膜外手术 (EP) 期间的麻醉药物。硬膜外注射通常用于治疗疼痛 椎间盘突出、椎管狭窄、化学椎间盘突出、宫颈手术后继发的慢性疼痛 综合征和椎间盘源性慢性颈痛。它们也经常用于缓解相关疼痛 到出生。然而，如果执行不当，硬膜外注射可能会产生副作用，例如 如剧烈头痛、感染，甚至神经损伤。还可能发生严重的副作用，包括 中风、瘫痪或视力丧失。 该提案旨在通过使用一种新颖的和更多的方法来克服当前与硬膜外注射相关的问题 可靠的低相干干涉测量 (LCI) 光学传感方法可确定存在的组织类型 在针尖处，同时监测施加在针上的力，以使其安全地进入硬膜外 使用光纤布拉格传感器的空间。 在第一阶段的努力中，PSSI 开发了一种用于硬膜外引导的实验室原型，该原型结合了 在同一探头内进行低相干干涉测量和布拉格传感。该方法经过测试并 在动物组织标本上进行了离体优化。尽管可行性已得到证明，但差异化 PSI 光源的相对高强度噪声在一定程度上阻碍了组织类型的识别 并在实验中使用。因此，我们请求 NIH 支持购买性能更好的光源， 以及支付更好地匹配光谱的合适布拉格光栅的一次性工程成本 该光源的特性。改进设置后，该技术将在活体动物身上进行评估。 基于第一阶段的研究结果，该技术将在第二阶段进一步改进并在 BWH 的人类。