Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

多变量人工胰腺系统可检测和减轻未经通知的体力活动和急性心理压力的影响

• 批准号: 10488195
• 负责人: Ali Cinar
• 金额: $ 50.3万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-12 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10488195
• 关键词: Activities of Daily Living; Acute; Address; Affect; Age; Algorithmic Software; Algorithms; Artificial Pancreas; Behavioral; Biomedical Engineering; Blood Glucose; Characteristics; Classification; Clinic; Clinical; Clinical Research; Complex; Coupled; Data; Databases; Detection; Diabetes Mellitus; Dose; Endocrinologist; Event; Exercise; Feedback; Fright; Funding; Future; Generations; Glucose; Hybrids; Hyperglycemia; Hypoglycemia; Individual; Infusion procedures; Insulin; Insulin-Dependent Diabetes Mellitus; Life; Manuals; Metabolic; Metabolism; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Nurses; Output; Patients; Performance; Persons; Physical activity; Physiological; Psychological Stress; Race; Research; Research Personnel; Scientist; Stress; System; Technology; Time; Training; Update; Variant; Work; acute stress; base; blood glucose regulation; classification algorithm; data streams; euglycemia; exercise physiologist; experimental study; glucose monitor; glucose sensor; glycemic control; improved; in silico; individual variation; machine learning algorithm; machine learning model; monitoring device; multidisciplinary; next generation; sedentary; sex; software development; user-friendly; wearable device

IIT Project Summary/Abstract The objective of this proposal is to demonstrate a viable, functionally integrated multivariable artificial pancreas that will mitigate meal, physical activity and acute psychological stress challenges without any manual inputs to better regulate glucose levels of people with diabetes. The first generation of artificial pancreas (AP) systems, the hybrid closed-loop AP, collects data from continuous glucose monitoring devices and relies on manual user inputs for mitigating the effects of meals and physical activities. Acute psychological stress and many other physical activities besides planned exercise can affect blood glucose levels and cause challenges to maintaining euglycemia for people with type 1 diabetes. Various physical activities and acute psychological stress events affect the metabolism and sensitivity to insulin in different ways. Hence, their types, intensities and durations, and their individual and concurrent presence must be detected in order to determine the optimal insulin administration. The multivariable artificial pancreas approach provides a well-integrated and user-friendly technology with minimal burden on the user and mitigates the effects of unexpected physical activities and acute psychological stress inducements. Additionally, this technology would be safer by reducing the number and duration of hypoglycemic and hyperglycemic events, compared to APs based exclusively on continuous glucose monitoring device data. Such multivariable AP systems can only be developed by using a sophisticated multivariable approach that uses real-time information from continuous glucose monitoring devices and physiological variables obtained from wearable devices worn in free-living daily life.

IIT 项目摘要/摘要 该提案的目的是展示一种可行的、功能集成的多变量 人工胰腺可以减轻进餐、体力活动和急性心理压力 无需任何手动输入即可更好地调节糖尿病患者血糖水平的挑战。 第一代人工胰腺（AP）系统，混合闭环AP，收集数据 来自连续血糖监测设备，并依赖于手动用户输入来减轻 膳食和身体活动的影响。急性心理压力和许多其他身体压力 计划锻炼之外的活动可能会影响血糖水平，并对血糖水平造成挑战 维持 1 型糖尿病患者的血糖正常。各种体力活动和急性 心理应激事件以不同方式影响新陈代谢和对胰岛素的敏感性。 因此，它们的类型、强度和持续时间，以及它们的单独和同时存在必须 进行检测以确定最佳的胰岛素给药方案。多变量人工 胰腺方法提供了一种集成良好且用户友好的技术，且负担最小 对用户并减轻意外的身体活动和急性心理的影响 压力诱因。此外，该技术通过减少数量和 与仅基于 AP 的情况相比，低血糖和高血糖事件的持续时间 连续血糖监测设备数据。这种多变量 AP 系统只能是 通过使用复杂的多变量方法开发，该方法使用来自 连续血糖监测设备和从可穿戴设备获得的生理变量 日常生活中佩戴的设备。

项目成果

Multivariable Automated Insulin Delivery System for Handling Planned and Spontaneous Physical Activities.

用于处理计划和自发身体活动的多变量自动胰岛素输送系统。

• 发表时间: 2023-11
• 作者: Askari, Mohammad Reza;Ahmadasas, Mohammad;Shahidehpour, Andrew;Rashid, Mudassir;Quinn, Laurie;Park, Minsun;Cinar, Ali
• 通讯作者: Cinar, Ali