Tai Chi and Fibromyalgia

太极拳和纤维肌痛

基本信息

批准号：
8187229
负责人：
CHENCHEN WANG
金额：
$ 71.29万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8187229
关键词：
Address Adverse effects Advocate Aerobic Aerobic Exercise Affect American Area Boston Cardiovascular system Chinese People Chronic Clinical Clinical Trials Clinical effectiveness Communities Diagnosis Disabled Persons Disease Dose Education Effectiveness Exercise Fatigue Fibromyalgia Frequencies Goals Health Healthcare Systems Impairment Individual Institute of Medicine (U.S.)Insurance Carriers Intervention Life Measures Medical Mental Health Mind-Body Intervention Muscle Musculoskeletal Pain Occupations Outcome Pain Pain Disorder Patients Perception Performance Personal Satisfaction Physical therapy exercises Policy Maker Population Quality of life Questionnaires Randomized Randomized Controlled Trials Regimen Research Rheumatology Schedule Self Efficacy Severities Sleep Sleep disturbances Stretching Symptoms Syndrome Tai Ji Testing Therapeutic Time United States Work blind body-mind chronic pain college combat comparative effectiveness conditioning cost disability payment disabling disease economic impact effective intervention effective therapy effectiveness research effectiveness trial flexibility follow-up group intervention health related quality of life improved innovation meetings metropolitan muscle strength novel physical conditioning primary outcome programs psychologic psychosocial satisfaction secondary outcome standard of care tool

项目摘要

DESCRIPTION (provided by applicant): Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome that causes substantial physical and psychological impairment and costs over $25 billion annually. Current pharmacological therapies may be expensive, cause serious adverse effects, and fail to effectively improve pain and function. Thus, finding new and effective non-pharmacological treatments for FM patients is urgently needed. Previous research has demonstrated that Tai Chi, a traditional Chinese mind-body exercise, can improve both physical and mental health for FM patients. However, no clinical trials have demonstrated its clinical effectiveness compared to standard aerobic exercise therapy, or determined its optimum dose (frequency or duration) as a treatment for FM. We therefore propose to conduct the first comparative effectiveness trial of Tai Chi vs. aerobic exercise (a recommended component of the current standard of care) and to evaluate effectiveness under different Tai Chi dosing schedules in a large FM population. We aim to (1) demonstrate that, compared to aerobic exercise, Tai Chi is a more effective intervention for managing the pain and improving the functional limitations that impact quality of life for FM patients, and 2) determine the optimal frequency and duration of a supervised Tai Chi intervention in relation to short and long-term effectiveness. To achieve this goal, we will conduct a single-blind, randomized controlled trial of Tai Chi vs. aerobic exercise in 216 patients who meet the American College of Rheumatology criteria for FM. Patients will be randomized to one of four Tai Chi intervention groups: 12 or 24 weeks of supervised Tai Chi given once or twice per week, or a supervised aerobic exercise control (2x/week for 24 weeks). All groups will have a 52-week follow-up. The primary outcome will be the FM Impact Questionnaire total score at 24 weeks. Secondary outcomes include the measures of widespread pain, functional performance, psychological functioning, self-efficacy, sleep quality, and quality of life at 12, 24, and 52 weeks. Successful completion of the proposed study will determine the ideal regimen of Tai Chi and demonstrate that Tai Chi can be a simple, effective, and durable treatment for this therapeutically challenging disorder. We believe that our work will convince the clinical community to implement Tai Chi as a first-line treatment for the millions of individuals with FM. PUBLIC HEALTH RELEVANCE: Fibromyalgia (FM) is the second most common rheumatologic condition in the United States and there are currently no satisfactory treatments. Innovative effective strategies are urgently needed. Tai Chi offers a novel and logistically feasible exercise regimen and a complementary mind-body approach to manage pain as well as enhance physical and mental health and wellness in patients with FM. Successful completion of the proposed study will demonstrate that Tai Chi is a simple, effective and durable treatment for FM. 1

描述（由申请人提供）：纤维肌痛（FM）是一种慢性肌肉骨骼疼痛综合征，会导致严重的身体和心理障碍，每年成本超过250亿美元。当前的药理疗法可能很昂贵，会导致严重的不良反应，并且无法有效改善疼痛和功能。因此，迫切需要为FM患者寻找新的和有效的非药物治疗。先前的研究表明，中国传统的心身运动Tai Chi可以改善FM患者的身心健康。但是，与标准有氧运动治疗相比，尚无临床试验证明其临床有效性，或者确定其最佳剂量（频率或持续时间）作为FM的治疗方法。因此，我们建议在大型FM人群中进行TAI CHI与有氧运动（当前护理标准的推荐组成部分）的首次比较有效性试验（当前护理标准的推荐组成部分），并评估在不同的Tai Chi剂量时间表下的有效性。我们的目的是（1）证明，与有氧运动相比，TAI Chi是管理疼痛并改善影响FM患者生活质量的功能局限性的更有效干预措施，以及2）确定与短期和长期有效性有关的受监督Tai Chi干预的最佳频率和持续时间。为了实现这一目标，我们将在216名符合美国风湿病学院的FM标准的TAI CHI与有氧运动的单盲，随机对照试验。患者将被随机分为四个太极干预组之一：每周一次或两次受监督的泰志有12或24周，或者有氧运动控制（2倍/周24周）。所有小组将进行52周的随访。主要结果将是24周的FM影响问卷总分。次要结果包括痛苦，功能性能，心理功能，自我效能，睡眠质量和生活质量的度量，在12、24和52周时。拟议的研究的成功完成将确定太极拳的理想方案，并证明太极拳对于这种治疗挑战性疾病可能是一种简单，有效且耐用的治疗方法。我们认为，我们的工作将说服临床界实施太极拳作为数百万FM患者的一线治疗。公共卫生相关性：纤维肌痛（FM）是美国第二常见的风湿病状况，目前尚无令人满意的治疗方法。迫切需要创新的有效策略。 Tai Chi提供了一种新颖且具有逻辑上可行的运动方案，并提供了一种互补的思维方式方法来控制疼痛，并增强了FM患者的身心健康和心理健康和健康。成功完成拟议的研究将表明，太极拳是FM的简单，有效且耐用的治疗方法。 1