Aspects of Bone Quality Among Chinese American Women

华裔美国女性骨骼质量的各个方面

• 批准号: 7843694
• 负责人: MARCELLA Donovan WALKER
• 金额: $ 12.86万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-06 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7843694
• 关键词: Accounting; Adopted; American; Arts; Asia; Asians; Bone Density; Caucasians; Caucasoid Race; Censuses; Chinese American; Chinese People; Clinical; Collagen; Data; Databases; Densitometry; Development; Diagnosis; Diagnostic; Dual-Energy X-Ray Absorptiometry; Electrons; Fourier Transform; Fracture; Goals; Guidelines; Hip Fractures; Hydroxyapatites; Image; Knowledge; Lead; Life; Measures; Metabolic Bone Diseases; Osteoporosis; Peripheral; Population; Populations at Risk; Postmenopausal Osteoporosis; Postmenopause; Property; Public Health; Race; Research; Research Personnel; Resolution; Risk; Techniques; Time; United States; Walkers; Woman; World Health Organization; X-Ray Computed Tomography; age related; bone; bone quality; bone strength; bone turnover; cohort; density; epidemiologic data; insight; men; mineralization; programs; prospective; racial difference; skeletal disorder; skills; spectroscopic imaging

DESCRIPTION (provided by applicant): Although osteoporosis is most common among Caucasian postmenopausal women, it is not infrequent among non-Caucasian women, particularly Chinese and Chinese American women. Chinese Americans are a growing population at risk for osteoporosis. The US Census Bureau estimates by 2050, one-tenth of the US population will be of Asian descent, many Chinese American. Osteoporosis is clearly an important public health problem among Chinese Americans. However, most epidemiologic data that relates bone mineral density (BMD) to fracture risk has been acquired among postmenopausal Caucasian women and it is, thus, only for this group that the densitometric definition of osteoporosis and treatment guidelines strictly apply. It s not known how BMD relates to fracture risk in the Chinese population nor what T-score accurately describes the population at risk. In the absence of prospective data, the T-score definition of osteoporosis or postmenopausal Caucasian women has been applied to other racial groups. Moreover, a Caucasian BMD referent database is used to assess fracture risk among Asian women. It is becoming increasingly apparent that racial differences in BMD and fracture risk make application of this definition and the Caucasian database problematic. For example, Chinese women in Asia and the US have a significantly lower rate of hip fracture than Caucasian women, despite the fact that areal BMD is lower among Chinese women. These findings suggest that the relationship between BMD and fracture risk may differ among Caucasian and Chinese women. The overall goal of this proposal is to characterize areal bone density as well as other aspects of bone quality, such as volumetric density, bone size, bone microarchitecture, remodeling, mineralization density, hydroxyapetite crystal size and matrix properties among Chinese American women. Comparing these new data to that of Caucasian women may provide insight into how, despite lower BMD, Chinese women are seemingly protected against hip fracture. This new knowledge may permit fracture risk to be more accurately determined among Chinese American women and may allow for the development of diagnostic and treatment guidelines that are directly relevant to the Chinese American population. This project will, in addition, enable me to acquire both the technical and research methodological skills necessary to develop into an independent investigator in metabolic bone disease.

描述（由申请人提供）：尽管骨质疏松症在绝经后妇女中最常见，但在非可口学妇女（尤其是中国美国妇女）中并不频繁。中国美国人是骨质疏松症风险的人口增长。美国人口普查局估计到2050年，美国人口的十分之一将是亚洲血统，许多美国人。骨质疏松症显然是华裔美国人的重要公共卫生问题。然而，在绝经后高加索妇女中，大多数将骨矿物质密度（BMD）（BMD）与骨折风险联系起来的流行病学数据是严格应用骨质疏松和治疗指南的密度测定的，因此仅严格应用了这一组。不知道BMD与中国人口中的破裂风险有何关系，也不知道T评分准确地描述了有风险的人口。在没有前瞻性数据的情况下，将骨质疏松症或绝经后高加索妇女的T评分定义应用于其他种族群体。此外，白人BMD参考数据库用于评估亚洲妇女的破裂风险。越来越明显的是，BMD和断裂风险的种族差异使该定义以及高加索数据库有问题。例如，尽管中国妇女的BMD较低，但亚洲和美国的中国妇女的髋部骨折率明显低于白人妇女。这些发现表明，白种人和中国妇女之间的关系与破裂风险之间的关系可能有所不同。该提议的总体目标是表征面积的骨密度以及骨质质量的其他方面，例如体积密度，骨骼大小，骨微体系结构，重塑，矿化密度，盐酸磷灰石晶体尺寸以及中国美国女性的基质特性。将这些新数据与高加索妇女的数据进行比较可能会洞悉，尽管BMD较低，但中国妇女似乎仍受到髋部骨折的保护。这些新知识可能会使骨折风险在美国女性妇女中更准确地确定，并可以制定与华裔美国人人口直接相关的诊断和治疗指南。此外，该项目将使我能够获得发展为代谢骨病的独立研究者所需的技术和研究方法学技能。