Aspects of Bone Quality Among Chinese American Women

华裔美国女性骨骼质量的各个方面

基本信息

批准号：
7439166
负责人：
MARCELLA Donovan WALKER
金额：
$ 12.86万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-06 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7439166
关键词：
Accounting Adopted American Arts Asia Asians Bone Density Caucasians Caucasoid Race Censuses Chinese American Chinese People Clinical Collagen Data Databases Densitometry Development Diagnosis Diagnostic Dual-Energy X-Ray Absorptiometry Electrons Fourier Transform Fracture Goals Guidelines Hip Fractures Hydroxyapatites Image Knowledge Lead Life Measures Metabolic Bone Diseases Osteoporosis Peripheral Population Populations at Risk Postmenopausal Osteoporosis Postmenopause Property Public Health Race Rate Research Research Personnel Resolution Risk Score Standards of Weights and Measures Techniques Time United States Walkers Woman World Health Organization X-Ray Computed Tomography age related bone bone quality bone strength bone turnover cohort density insight men mineralization programs prospective racial difference size skeletal disorder skills spectroscopic imaging

项目摘要

DESCRIPTION (provided by applicant): Although osteoporosis is most common among Caucasian postmenopausal women, it is not infrequent among non-Caucasian women, particularly Chinese and Chinese American women. Chinese Americans are a growing population at risk for osteoporosis. The US Census Bureau estimates by 2050, one-tenth of the US population will be of Asian descent, many Chinese American. Osteoporosis is clearly an important public health problem among Chinese Americans. However, most epidemiologic data that relates bone mineral density (BMD) to fracture risk has been acquired among postmenopausal Caucasian women and it is, thus, only for this group that the densitometric definition of osteoporosis and treatment guidelines strictly apply. It s not known how BMD relates to fracture risk in the Chinese population nor what T-score accurately describes the population at risk. In the absence of prospective data, the T-score definition of osteoporosis or postmenopausal Caucasian women has been applied to other racial groups. Moreover, a Caucasian BMD referent database is used to assess fracture risk among Asian women. It is becoming increasingly apparent that racial differences in BMD and fracture risk make application of this definition and the Caucasian database problematic. For example, Chinese women in Asia and the US have a significantly lower rate of hip fracture than Caucasian women, despite the fact that areal BMD is lower among Chinese women. These findings suggest that the relationship between BMD and fracture risk may differ among Caucasian and Chinese women. The overall goal of this proposal is to characterize areal bone density as well as other aspects of bone quality, such as volumetric density, bone size, bone microarchitecture, remodeling, mineralization density, hydroxyapetite crystal size and matrix properties among Chinese American women. Comparing these new data to that of Caucasian women may provide insight into how, despite lower BMD, Chinese women are seemingly protected against hip fracture. This new knowledge may permit fracture risk to be more accurately determined among Chinese American women and may allow for the development of diagnostic and treatment guidelines that are directly relevant to the Chinese American population. This project will, in addition, enable me to acquire both the technical and research methodological skills necessary to develop into an independent investigator in metabolic bone disease.

描述（由申请人提供）：虽然骨质疏松症在白人绝经后女性中最常见，但在非白人女性中也很常见，特别是华裔和华裔美国女性。越来越多的美国人面临骨质疏松症的风险。美国人口普查局估计，到 2050 年，十分之一的美国人口将是亚裔，其中许多是华裔美国人。骨质疏松症显然是华裔美国人中一个重要的公共卫生问题。然而，大多数将骨矿物质密度（BMD）与骨折风险相关的流行病学数据都是在绝经后白人女性中获得的，因此，骨质疏松症的密度定义和治疗指南仅严格适用于该群体。目前尚不清楚 BMD 与中国人群的骨折风险有何关系，也不知道什么 T 分数可以准确描述处于危险中的人群。在缺乏前瞻性数据的情况下，骨质疏松症或绝经后白人女性的 T 评分定义已应用于其他种族群体。此外，高加索骨密度参考数据库用于评估亚洲女性的骨折风险。越来越明显的是，骨密度和骨折风险的种族差异使得这一定义和白种人数据库的应用存在问题。例如，尽管中国女性的面积骨密度较低，但亚洲和美国的中国女性髋部骨折发生率却明显低于白人女性。这些发现表明，白种人和中国女性的骨密度和骨折风险之间的关系可能有所不同。该提案的总体目标是表征华裔美国女性的面骨密度以及骨质量的其他方面，例如体积密度、骨尺寸、骨微结构、重塑、矿化密度、羟磷灰石晶体尺寸和基质特性。将这些新数据与白人女性的数据进行比较，可能有助于了解尽管中国女性骨密度较低，但似乎可以预防髋部骨折。这一新知识可能有助于更准确地确定华裔美国女性的骨折风险，并可能有助于制定与华裔美国人口直接相关的诊断和治疗指南。此外，该项目将使我能够获得发展成为代谢性骨疾病的独立研究者所需的技术和研究方法技能。