Vestibular contribution to the control of human upright stance

前庭对人类直立姿势控制的贡献

• 批准号: 8236336
• 负责人: Robert J Peterka
• 金额: $ 33.43万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8236336
• 关键词: Accounting; Aging; Anterior; Bilateral; Characteristics; Conflict (Psychology); Cues; Data; Development; Disease; Engineering; Environment; Equilibrium; Experimental Models; Feedback; Financial compensation; Future; Goals; Head; Human; Investigation; Labyrinth; Lateral; Left; Measures; Medial; Methods; Modeling; Morbidity - disease rate; Motion; Motor; Nervous system structure; Patients; Pattern; Persons; Population; Property; Proprioception; Prosthesis; Research; Sensory; Signal Transduction; Source; Stimulus; Surface; System; Testing; Time; Vestibular loss; Vision; Visual; Visual system structure; Work; base; design; equilibration disorder; falls; insight; mathematical model; method development; mortality; receptor; research study; response; sensor; sensory system; somatosensory; tool; vestibular prosthesis

DESCRIPTION (provided by applicant): The long-term goals of this project are to understand how motion information from the inner-ear balance sensors of the vestibular system contributes to the control of balance in humans and to determine the extent to which galvanic vestibular stimulation (GVS) can be used to restore a useful vestibular contribution to balance in subjects with diminished vestibular function. GVS has long been used to demonstrate qualitatively a vestibular contribution to balance control, but a detailed quantitative understanding is lacking. Engineering system-identification methods and modeling will be applied to develop GVS as a quantitative tool for investigating the vestibular contribution to balance control and as a potential prosthetic aid to enhance balance in subjects with vestibular deficits. The proposed work has three specific aims. The first aim will combine experimental and modeling methods to: (1) define how motion information from vestibular sensors contributes to balance control, (2) determine how vestibular orientation information is combined with information from proprioceptive, somatosensory, and visual systems, (3) determine how combined sensory information is used to generate corrective responses to external perturbations imposed on a multi-segmental body, and (4) identify how subjects with bilateral vestibular loss (BVL) compensate for their vestibular loss. Models developed in the first aim provide quantitative hypotheses about mechanisms controlling balance. The second aim will use results from GVS tests to identify aspects of GVS-evoked body sway that differ from sway expected from the natural activation of vestibular receptors by actual head motion. We will develop a method that accounts for these differences, and then use GVS to test whether our model-based hypotheses of multi-segmental balance control predict how the vestibular contribution to balance control changes as a function of environmental and stimulus conditions. The third aim will use the identified characteristics of GVS-evoked balance responses and a model-based understanding of the balance control system to develop a method that uses GVS feedback, based on real-time measures of head motion, to manipulate the vestibular contribution to balance control. Because many BVL subjects remain sensitive to GVS, the potential exists for real-time GVS feedback to restore a functionally useful vestibular contribution to balance control in BVL subjects. Successful completion of the proposed experiments will provide new insights into the vestibular contribution to human balance control and mechanisms that compensate for vestibular loss. The development of methods for accurately manipulating vestibular-motion information using GVS feedback will facilitate future investigations of the vestibular contribution to motor tasks and could potentially contribute to the development of a vestibular prosthesis. PUBLIC HEALTH RELEVANCE: Balance disorders leave a subject vulnerable to falls and the increased morbidity and mortality associated with falling. The proposed research will provide a greater understanding about how the nervous system uses orientation information from the inner ear's vestibular sensors for balance control, will determine what limits vestibular compensation, and will investigate a method for restoring some level of vestibular control of balance in subjects with deficient vestibular function.

描述（由申请人提供）：该项目的长期目标是了解前庭系统内耳平衡传感器的运动信息如何有助于控制人类平衡，并确定可以使用电力前庭刺激（GVS）来恢复有用的前庭贡献，以使对受试者的有用贡献，以平衡前庭函数。长期以来，GV已被用来质量地证明对平衡控制的前庭贡献，但是缺乏详细的定量理解。工程系统识别方法和建模将用于开发GV作为定量工具，以研究对平衡控制的前庭贡献，并作为增强前庭缺陷受试者平衡的潜在假肢。 拟议的工作具有三个具体目标。第一个目的将结合实验和建模方法：（1）定义来自前庭传感器的运动信息如何有助于平衡控制，（2）确定前庭方向信息与本体感受，体感和视觉系统的信息结合在一起，（3）使用对物体的组合范围，并确定多个范围的构成范围，并确定多个范围的范围，并确定多个范围的范围。前庭损失（BVL）补偿其前庭损失。第一个目标中开发的模型提供了有关控制平衡机制的定量假设。第二个目标将使用GVS测试的结果来识别GVS诱发的身体摇摆方面的各个方面，这与通过实际头部运动的前庭受体的自然激活所期望的摇摆不同。我们将开发一种解决这些差异的方法，然后使用GV来测试我们基于模型的多段平衡控制的假设是否预测了前庭控制对控制控制的贡献如何随环境和刺激条件的函数而变化。第三个目标将使用GVS诱发的平衡响应的确定特征以及基于模型的平衡控制系统的理解，以开发一种基于实时头部运动的实时测量的方法，以操纵前庭贡献以平衡控制。由于许多BVL受试者对GV仍然敏感，因此存在实时GVS反馈的潜在，以恢复功能上有用的前庭贡献，以平衡BVL受试者的控制。 成功完成拟议的实验将为对人类平衡控制和补偿前庭损失的机制的贡献提供新的见解。使用GVS反馈来准确操纵前庭动作信息的方法的开发将有助于对前庭任务的前庭贡献的未来研究，并有可能有助于前庭假体的发展。 公共卫生相关性：平衡障碍使一个容易受到跌倒的主题以及与跌倒有关的发病率和死亡率的增加。拟议的研究将对神经系统如何使用内耳的前庭传感器进行平衡控制的方向信息有更多的了解，将确定哪些限制前庭薪酬，并将研究一种方法，以恢复缺乏前庭功能的受试者的一定程度的前庭控制平衡。