NEW METHOD TO IDENTIFY UNILATERAL VESTIBULAR DYSFUNCTION

识别单侧前庭功能障碍的新方法

• 批准号: 6379578
• 负责人: Robert J Peterka
• 金额: $ 24.84万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379578
• 关键词: clinical research; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; ear disorder diagnosis; electrooculography; eye movements; head movements; hearing tests; human subject; interview; mathematical model; nystagmus; semicircular duct; vestibular apparatus; vestibuloocular reflex

DESCRIPTION:(adapted from applicant's abstract) The long-term goal of this project is to develop a new clinical test that can identify and characterize the severity of an asymmetry of vestibular function between the two ears. Preliminary results suggest that a test based on measurement of vestibulo-ocular reflex (VOR) eye movements evoked by a novel rotational stimulus can overcome the significant limitations of the two main clinical tests (caloric and conventional rotation) currently used to evaluate vestibular function. If proven effective, this diagnostic test could be rapidly adopted into clinical practice since rotation test equipment capable of delivering the proposed new rotational stimulus is currently in used in most major medical centers. There are three specific aims in the proposal. The first aim is to use modeling and simulation studies to investigate how physiological properties of vestibular-nerve afferents and VOR are likely to influence the ability of the new rotational stimulus to accurately identify a vestibular asymmetry. These properties include static and dynamic characteristics of primary semicircular canal afferents, orientation of the semicircular canals with respect to one another and with respect to the rotation axis, and dynamic characteristics of nystagmus generated in response to large amplitude rotational motions. The second aim is to use experimental studies to determine exact specifications for the new rotational stimulus, and to investigate methodological factors that influence the sensitivity of the new test. The third aim is to verify the clinical applicability of the proposed new test by comparing results from caloric and conventional rotation tests with results from the proposed new rotation test. Experimental results from subjects with different levels of partial unilateral vestibular loss will determine the effectiveness and reliability of the proposed new rotation test.

描述：（改编自申请人的摘要） 该项目的长期目标是开发一个新的临床测试，可以 识别并表征前庭功能不对称的严重程度 在两只耳朵之间。初步结果表明，基于 小说中唤起的前庭 - 眼反射（VOR）眼动动作的测量 旋转刺激可以克服两个主的显着局限性 目前用于评估的临床测试（热量和常规旋转） 前庭功能。如果被证明有效，此诊断测试可能会迅速 由于旋转测试设备能够 目前，大多数人都使用了提议的新旋转刺激 主要医疗中心。 该提案中有三​​个特定的目标。第一个目的是使用建模 和模拟研究以研究如何 前庭障碍传入和VOR可能会影响 新的旋转刺激以准确识别前庭不对称。这些 特性包括一级半圆形的静态和动态特征 运河传入，半圆形管相对于一个 在旋转轴和动态特征方面 响应较大的振幅旋转运动而产生的眼球震颤。这 第二个目的是使用实验研究来确定 新的旋转刺激，并研究方法论因素 影响新测试的灵敏度。第三个目的是验证 提出的新测试的临床适用性通过比较 热量和常规旋转测试与拟议的新的结果 旋转测试。来自不同水平的受试者的实验结果 部分单侧前庭损失将决定有效性和 拟议的新旋转测试的可靠性。