EXTENDING INDEPENDENCE AND QUALITY OF LIFE FOR PEOPLE WITH ALZHEIMER'S DISEASE OR DEMENTIA THROUGH TELEHEALTH PROGRAM DELIVERY

通过远程医疗计划的实施，提高阿尔茨海默病或痴呆症患者的独立性和生活质量

• 批准号: 10019891
• 负责人: Deborah E. Barnes
• 金额: $ 142.87万
• 依托单位: TOGETHER SENIOR HEALTH, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10019891
• 关键词: Alzheimer' s Disease; Alzheimer' s disease caregiver; American; Behavior Therapy; Behavioral; California; Caregivers; Caring; Child; Client; Clinical Trials; Cognitive; Communities; Control Groups; Couples; Dementia; Development; Devices; Disease; Dose; Education; Elements; Emotional; Environment; Evidence based program; Feedback; Friends; Geriatrics; Goals; Grant; Growth; Health; Home environment; Human; Integrative Medicine; Intervention Studies; Logistics; Measures; Memory Loss; Methods; Mission; Modeling; Parents; Participant; Personal Satisfaction; Persons; Pharmaceutical Preparations; Phase; Preparation; Prevalence; Psychology; Public Health; Qualitative Methods; Quality of life; Randomized Controlled Trials; Reporting; Research Personnel; Research Proposals; San Francisco; Small Business Innovation Research Grant; Social Problems; Social isolation; Stream; Symptoms; Teacher Professional Development; Technology; Testing; Thinking; Training Programs; Training Support; Transportation; Triad Acrylic Resin; Underserved Population; Universities; Vulnerable Populations; Waiting Lists; base; cohort; commercialization; design; digital; distraction; evidence base; experience; improved; innovation; innovative technologies; instructor; mild cognitive impairment; novel strategies; programs; prototype; response; side effect; social; telehealth; tool; user-friendly; virtual; web portal; web site

Mission Statement: Together Senior Health, Inc. (TOGETHER), is committed to helping people living with Alzheimer’s Disease and Related Disorders (ADRD) and their caregivers maximize quality of life by delivering livestreaming, evidence-based, virtual group programs to them in their homes. Significance: There are currently 5.8 million people in the U.S. living with ADRD and more than 16 million unpaid caregivers. Current ADRD medications help with some symptoms but do not change the disease course and are often stopped due to side effects. In addition, most evidence-based behavioral interventions—such as our in-person Moving Together program—are not widely available to people in their local communities. Innovation: TOGETHER is bridging this gap by using human centered design principles—in which the user is involved with all phases of design and testing—to develop and test an innovative, user-friendly platform for delivering livestreaming virtual group programs to people with ADRD and caregivers in their homes. Investigators: TOGETHER’s CEO and PI of this application has expertise in human centered design and successfully led our Phase I Small Business Innovation Research (SBIR) grant. Coinvestigators and consultants bring expertise in clinical trials, integrative health, behavioral psychology, geriatrics, qualitative methods, technology and education. Approach: Phase I Progress. Our Phase I SBIR enabled us to develop and demonstrate proof-of-concept for our unique approach to livestreaming virtual group program delivery. We have completed or exceeded all of our milestones, which included: 1) creating the platform in partnership with graduates of our in-person program; 2) pilot-testing the platform in a naïve group of users and 3) refining the platform in preparation for Phase II. The response has been exceptional, with participants highlighting many physical, social, emotional, and logistical benefits. Phase II Aims: The primary goals of this SBIR Phase II grant are to: 1) determine whether livestreaming virtual group delivery of the Moving Together program improves quality of life in people with mild ADRD and caregivers, including exploration of potential mechanisms of action; 2) refine the platform for people with mild cognitive impairment to expand our target audience; and 3) develop an instructor training program to meet the needs of a larger client base. Environment: TOGETHER’S corporate office is in San Francisco, which offers a rich environment for developing and testing innovative technology-based solutions to challenging social problems and is enhanced by involvement of investigators at the University of California, San Francisco (UCSF) and San Francisco VA. Commercialization Plan: After completion of Phase II, we will be prepared to commercialize TOGETHER’s telehealth platform, initially using a client pay model, with clear plans for growth and expansion. Summary: TOGETHER’s innovative approach to livestreaming virtual group delivery of evidence-based programs for people with ADRD and caregivers in their homes offers tremendous potential to increase access and improve quality of life in this vulnerable and under-served population.

使命宣言：Together Senior Health, Inc. (TOGETHER) 致力于帮助患有以下疾病的人们 阿尔茨海默氏病及相关疾病 (ADRD) 及其护理人员通过提供 在家中向他们提供基于证据的直播、虚拟团体节目 意义：有。 目前，美国有 580 万人患有 ADRD，并且有超过 1600 万无薪护理人员。 ADRD 药物有助于缓解某些症状，但不会改变病程，并且通常会停止使用 此外，大多数基于证据的行为干预措施，例如我们的亲自搬家。 Together 计划——当地社区的人们并未广泛参与创新：TOGETHER 是。 通过使用以人为本的设计原则来弥合这一差距，其中用户参与了所有阶段 设计和测试——开发和测试一个创新的、用户友好的平台，用于提供虚拟直播 针对 ADRD 患者和家中护理人员的团体计划：TOGETHER 的首席执行官和 该应用程序的 PI 拥有以人为本的设计方面的专业知识，并成功领导了我们的第一阶段小型企业 创新研究 (SBIR) 资助，共同研究者和顾问带来临床试验、综合方面的专业知识。 健康、行为心理学、老年病学、定性方法、技术和教育。 第一阶段 SBIR 的进展使我们能够开发并演示我们独特方法的概念验证。 我们已经完成或超越了所有里程碑。 包括：1) 与我们的面对面项目的毕业生合作创建平台；2) 进行试点测试 3) 完善平台，为第二阶段做准备。 非常出色，突出了许多身体、社交、情感和后勤方面的好处。 II 目标：SBIR 第二阶段资助的主要目标是：1）确定直播虚拟群组是否 “一起行动”计划的实施可改善轻度 ADRD 患者和护理人员的生活质量， 2）完善针对轻度认知人群的平台 扩大我们的目标受众；以及 3) 制定教练培训计划以满足以下人员的需求： 更大的客户群：TOGETHER 的公司办公室位于旧金山，提供丰富的服务。 开发和测试基于创新技术的解决方案以应对具有挑战性的社会问题的环境 加州大学旧金山分校 (UCSF) 和旧金山大学的研究人员的参与得到了加强 Francisco VA。商业化计划：第二阶段完成后，我们将准备商业化。 TOGETHER 的远程医疗平台最初采用客户付费模式，并制定了明确的增长和扩张计划。 摘要：TOGETHER 的创新方法通过直播虚拟小组交付基于证据的内容 针对 ADRD 患者及其家中护理人员的计划为增加获得服务的机会提供了巨大潜力 并改善这些弱势且服务不足的人群的生活质量。