5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center

5/14 APOL1长期肾移植结果网络（APOLLO）临床中心

基本信息

批准号：
10731162
负责人：
Sumit Mohan
金额：
$ 18.01万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10731162
关键词：
APOL1 gene Acceleration Acute Address African American African ancestry Albumins Allografting American Antibodies Apolipoproteins Bacterial Infections Biopsy Black race Blood Clinical Clinical Data Clinical Investigator Collaborations Collection Consent Cost Savings Counseling Creatinine DNA Data Data Set Disparity Donor person Education Enrollment Ensure Environmental Risk Factor Epidemiology European Evaluation Face Failure Future Genes Genetic Genotype Geography Goals Graft Survival HLA Antigens Health Health Care Costs Healthcare Hispanic Immunology Immunosuppression Individual Infrastructure Kidney Kidney Failure Kidney Transplantation Lesion Living Donors Longterm Follow-up Measures Medical Medical center Meridians New England Organ Outcome Outcomes Research Participant Pattern Pediatric Hospitals Pennsylvania Phase Phenotype Philadelphia Policies Prevalence Proteinuria Quality of life Recording of previous events Recurrent disease Registries Renal function Reporting Research Resources Risk Role Safety Serum Site Slide Time Transplant Recipients Transplantation United Network for Organ Sharing United States National Institutes of Health Universities Urine Variant Virus Diseases clinical center cohort data registry digital pathology ethnic difference experience follow-up gene interaction genetic risk factor graft failure high risk improved kidney biopsy living kidney donor member multidisciplinary novel patient retention post-transplant primary outcome programs prospective racial difference recruit repository risk variant secondary outcome transplant centers

项目摘要

ABSTRACT The Columbia-Penn Clinical Consortium APOLLO-CC05 brings together an experienced multidisciplinary team of clinical investigators with expertise in the fields of transplant epidemiology, immunology, and genetics, as well as an extensive history of collaboration with the United Network for Organ Sharing (UNOS) and other CPCC member transplant programs. As a result, the CC05 is well suited to recruit and retain patients for longitudinal follow up for the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO) Phase 2. This Clinical Center is composed of 11 transplant centers in four contiguous states (NY, NJ, CT and PA) in the Northeastern US. Our primary objective is to provide long-term follow up data on all APOLLO Phase 1 participants while continuing to enroll new African American or Black Hispanic living kidney donors (Aim 1). We will provide detailed clinical data (not currently available in any registry dataset) with the goal of identifying “second hits” and collect additional biospecimens (Urine albumin to creatinine ratio, blood, urine and biopsy slides) for Aim 2. We will partner with the SDRC to provide return of APOL1 genotype results to all participants who wish to receive them (Aim 3). We expect that Phase 2 of the APOLLO study will determine the impact of APOL1 risk variants in donors and recipients on kidney transplant outcomes and will create a unique cohort of African American living kidney donors with detailed clinical data and biospecimens as a resource for future studies.

抽象的哥伦比亚-宾夕法尼亚临床联盟 APOLLO-CC05 汇集了经验丰富的专家由具有移植领域专业知识的临床研究人员组成的多学科团队流行病学、免疫学和遗传学，以及与器官共享联合网络 (UNOS) 和其他 CPCC 成员移植计划。因此，CC05 非常适合招募和留住患者进行纵向随访 APOL1 长期肾移植结果研究网络 (APOLLO) 第 2 阶段。该临床中心由位于四个相邻州（纽约州、新泽西州、康涅狄格州）的 11 个移植中心组成和 PA）在美国东北部的主要目标是提供长期跟踪数据。所有 APOLLO 第一阶段参与者，同时继续招募新的非裔美国人或黑人西班牙裔活体肾脏捐赠者（目标 1）。我们将提供详细的临床数据（目前不提供）。任何注册表数据集中都有），目的是识别“第二次点击”并收集额外的信息目标 2 的生物样本（尿白蛋白与肌酐比、血液、尿液和活检切片）。我们将与 SDRC 合作，向所有参与者提供 APOL1 基因型结果返回希望收到它们（目标 3）。我们预计 APOLLO 研究的第二阶段将确定供体和受者 APOL1 风险变异对肾移植结果的影响创建一个独特的非裔美国人活体肾脏捐赠者队列，提供详细的临床数据和生物样本作为未来研究的资源。

项目成果

期刊论文数量（48）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Patients prioritize waitlist over posttransplant outcomes when evaluating kidney transplant centers.

在评估肾移植中心时，患者优先考虑等待名单而不是移植后结果。

DOI：
发表时间：
2018-11
期刊：
影响因子：
0
作者：
Husain, Syed Ali;Brennan, Corey;Michelson, Ariane;Tsapepas, Demetra;Patzer, Rachel E;Schold, Jesse D;Mohan, Sumit
通讯作者：
Mohan, Sumit

Regional Disparities in Transplantation With Deceased Donor Kidneys With Kidney Donor Profile Index Less Than 20% Among Candidates With Top 20% Estimated Post Transplant Survival.

地区%20差异%20in%20移植%20With%20已故%20捐赠者%20肾脏%20With%20肾脏%20捐赠者%20概况%20指数%20少于%20比%2020%%20其中%20候选人%20与%20顶部%2020%%20估计%20后%20移植%

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Husain, S Ali;King, Kristen L;Dube, Geoffrey K;Tsapepas, Demetra;Cohen, David J;Ratner, Lloyd E;Mohan, Sumit
通讯作者：
Mohan, Sumit

Using race in the estimation of glomerular filtration rates: time for a reversal?

使用种族来估计肾小球滤过率：是时候逆转了吗？