3/14 ApoL1 Long-Term Kidney Transplantation Outcomes Network (Apollo) Clinical Center

3/14 ApoL1长期肾移植结果网络（Apollo）临床中心

基本信息

批准号：
10730717
负责人：
Daniel Conlon Brennan
金额：
$ 28.02万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10730717
关键词：
AIDS-Associated Nephropathy APOL1 gene Acceleration Acute Address Africa South of the Sahara African American African ancestry Albumins Alleles Allografting American Antibodies Apolipoproteins Bacterial Infections Biological Biopsy Blood Clinical Clinical Data Consent Cost Savings Counseling Creatinine DNA Data Disparity Education End stage renal failure Enrollment Ensure European Evaluation Face Failure Focal and Segmental Glomerulosclerosis Future Genes Genetic Genotype Geography Graft Survival HLA Antigens HTATIP2 gene Health Care Costs Hypertension Immunosuppression Individual Kidney Kidney Diseases Kidney Failure Kidney Transplantation Lesion Living Donors Longterm Follow-up Measures Medical National Institute of Diabetes and Digestive and Kidney Diseases Organ Outcome Outcome Assessment Outcome Study Participant Patients Pattern Persons Phase Phenotype Policies Prevalence Proteinuria Quality of life Recurrent disease Registries Renal function Reporting Research Research Design Research Personnel Resources Risk Role Safety Sampling Serum Site Slide Specimen Time Transplant Recipients Transplantation United Network for Organ Sharing United States United States National Institutes of Health Universities Urine Variant Virus Diseases Vital Status clinical center clinical practice cohort digital pathology ethnic difference follow-up functional outcomes gene interaction genetic variant graft failure high risk improved kidney allograft kidney biopsy novel post-transplant primary outcome programs prospective racial difference rate of change recruit repository risk variant secondary outcome

项目摘要

Project Summary Genetic variants in APOL1 commonly found in people of Western Sub-Saharan Africa ancestry are associated with kidney diseases such as Focal Segmental Glomerulosclerosis, Hypertension Attributed-End Stage Kidney Disease, and HIV-Associated Nephropathy. The presence of 2 APOL1- renal risk variants (RRV) in deceased donors is associated with 2-to-4-times higher risk of renal graft loss in the recipient. Living donors with APOL1 risk alleles may be at risk for kidney disease. The NIH established the “APOL1 Long-term Kidney Transplantation Outcomes” (APOLLO) U01 Consortium in 2017. The APOLLO Consortium includes 13 clinical centers (CCs) with 4 paired core Centers to study the role of APOL1. The Johns Hopkins/Saint Louis University CC is CC3. The primary objectives of the APOLLO Consortium are to assess outcomes in patients across the entire United States who receive a kidney from an AA donor, or other individuals with recent African ancestry, and to evaluate the association of APOL1 genotype with renal allograft function-related outcomes. The primary outcome is time to graft failure in the recipients. Other outcomes include the rate of change of kidney function in recipients, rates of acute rejection of the kidney transplant, and proteinuria. The APOLLO Consortium also ascertains meaningful longitudinal outcomes in AA living donors (LDs), focusing on vital status and renal function, as well as proteinuria. While APOLLO enrolls LDs, their relative numbers have been limited, highlighting the need for additional studies designed to more thoroughly define the relationships of APOL1 genotype with long-term LD outcomes This application seeks to build on and extend the findings of the APOLLO study to inform clinical practice by a) providing data regarding the effects of APOL1 genotype on outcomes of the recipients of kidneys from AA donors, b) providing data regarding the effects of APOL1 genotype on long-term survival and renal functional outcomes of AA LDs and their recipients, and c) establishing a resource of clinical and genetic data and biological specimens for the APOLLO Consortium and other future researchers through the NIDDK Central Repository.

项目概要 APOL1 基因变异常见于西撒哈拉以南非洲血统的人与局灶节段性肾小球硬化症、高血压等肾脏疾病有关归因于终末期肾病和 HIV 相关肾病 2 的存在。 APOL1-已故捐献者的肾脏风险变异 (RRV) 与 2 至 4 倍的高风险相关具有 APOL1 风险等位基因的活体捐献者可能面临肾脏的风险。 NIH 制定了“APOL1 长期肾移植结果”。 (APOLLO) 2017 年 U01 联盟。APOLLO 联盟包括 13 个临床中心 (CC) 与 4 个配对核心中心研究 APOL1 的作用。大学 CC 是 CC3。APOLLO 联盟的主要目标是评估。全美国接受 AA 捐赠者肾脏的患者的结果，或其他具有近期非洲血统的个体，并评估 APOL1 基因型的关联同种异体移植肾功能相关的结果主要是移植失败的时间。其他结果包括受者肾功能的变化率、 APOLLO 联盟还确定了肾移植的急性排斥反应和蛋白尿。 AA 活体捐赠者 (LD) 的有意义的纵向结果，重点关注生命状态和肾脏功能，以及蛋白尿，而 APOLLO 登记了 LD，其相对数量为有限，强调需要进行更多研究来更彻底地定义 APOL1 基因型与长期 LD 结果的关系该应用旨在建立在并通过 a) 提供数据来扩展 APOLLO 研究的结果以指导临床实践关于 APOL1 基因型对 AA 肾脏受者结局的影响捐助者，b) 提供有关 APOL1 基因型对长期生存的影响的数据，以及 AA LD 及其接受者的肾功能结果，以及 c) 建立临床资源以及阿波罗联盟和其他未来的遗传数据和生物样本研究人员通过 NIDDK 中央存储库。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Utility of Serial Donor-derived Cell-free DNA Measurements for Detecting Allograft Rejection in a Kidney Transplant Recipient After PD-1 Checkpoint Inhibitor Administration.

使用连续供体来源的游离 DNA 测量来检测肾移植受者注射 PD-1 检查点抑制剂后的同种异体移植排斥反应。

DOI：
发表时间：
2021-02
期刊：
影响因子：
2.3
作者：
Lakhani, Laila;Alasfar, Sami;Bhalla, Anshul;Aala, Amtul;Rosenberg, Avi;Ostrander, Darin;Schollenberger, Megan D;Brennan, Daniel C;Lipson, Evan J
通讯作者：
Lipson, Evan J

Range and Consistency of Infection Outcomes Reported in Trials Conducted in Kidney Transplant Recipients: A Systematic Review.

在肾移植受者中进行的试验中报告的感染结果的范围和一致性：系统评价。

DOI：
发表时间：
2021
期刊：
影响因子：
6.2
作者：
Chan, Samuel;Au, Eric;Johnson, David W;Hawley, Carmel M;Tong, Allison;Pascoe, Elaine M;Craig, Jonathan C;Sautenet, Benedicte;Blumberg, Emily A;Brennan, Daniel;Campbell, Scott B;Cao, Christopher;Francis, Ross S;Huuskes, Brooke;Isbel, Nicole M
通讯作者：
Isbel, Nicole M

Critically important outcomes for infection in trials in kidney transplantation: An international survey of patients, caregivers, and health professionals.

肾移植试验中感染的极其重要的结果：对患者、护理人员和卫生专业人员的国际调查。

DOI：
发表时间：
2022-06
期刊：
影响因子：
2.1
作者：
Chan, Samuel;Howell, Martin;Johnson, David W;Hawley, Carmel M;Tong, Allison;Craig, Jonathan C;Cao, Christopher;Blumberg, Emily;Brennan, Daniel;Campbell, Scott B;Francis, Ross S;Huuskes, Brooke M;Isbel, Nicole M;Knoll, Greg;Kotton, Camille;M
通讯作者：
M

Everyday People Sing a Simple Song: Establishing a Core Outcome for Life Participation.

日常生活中人们唱着一首简单的歌：建立生活参与的核心成果。